<i>Helicobacter pylori</i>and gastric cancer: Indian enigma

Misra, Vatsala; Pandey, Renu; Misra, Sri Prakash; Dwivedi, Manisha

doi:10.3748/wjg.v20.i6.1503

Cited by 42 publications

(35 citation statements)

References 51 publications

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“…(17) Approximately 50 percent of the world's population has been estimated to be infected with H. Pylori. (18) The prevalence of H. Pylori infection in India is seen to be around fifty to eighty percent, but the incidence of GC is comparatively low indicating mixed results for the association between H. pylori and GC, (19) Epidemiological studies have shown mixed results for a definite association between H. Pylori and GC in approximately 50% patients, and a negative relationship in the remaining patients. (20) A study in North India on the prevalence of H. Pylori in patients with gastric carcinoma was assessed and correlated with gross appearance and histological types.…”

Section: Discussionmentioning

confidence: 99%

Clinico - Demographic Profi Le of Gastric Cancer in Kashmir

Mustafa¹,

Rashid²,

Zaffar³

et al. 2015

jemds

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BACKGROUND: Gastric cancer (GC) is the fourth most common cancer in the world. Worldwide it constitutes the second leading cause of cancer related death in both the sexes. There is a wide demographic variation seen with GC, with Asian countries like China alone representing almost 42% of the world's GC burden. Over the years the western nations have reported a decrease in the incidence of GC but with an increasing incidence of proximally located GCs, whereas most of Asian countries have distally located cancers. AIMS & OBJECTIVES: To Analyze the 'Clinic-Demographic' profile of gastric cancer in Kashmir valley MATERIALS & METHOD: We conducted an analytical, non-randomized, cross-sectional study on the Clinico-Demographic profile of 330 patients with primary GC who reported to our OPD between July2011 to July 2015. RESULTS: Over a period of four years 330 patients of primary GC were analyzed. Majority were males. Mean age of the patients was 62 years. Majority were smokers & non-vegetarian and none consumed alcohol. Tumor location was proximal in 13% & distal in 62% with no gender predilection. Median age of the patients was 60 years. Commonest presenting symptom in both the sexes was pain abdomen. Demographic shifts reported in western literature were not consistent with our data. CONCLUSION: Most of our patients present in late stage with adverse clinicopathological factors. The median age group of enrolled patients is lower than those in the west. Most of the patients are males, from a rural background with more than one symptom, out of which pain abdomen, weight loss are commonest. The trend of proximal shift in the site of cancer as projected by other studies was not observed in our population.

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Section: Discussionmentioning

confidence: 99%

Clinico - Demographic Profi Le of Gastric Cancer in Kashmir

Mustafa¹,

Rashid²,

Zaffar³

et al. 2015

jemds

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“…Variation in apoptotic index also correlated with the change in the pattern of Arg/Arg allele in various diseases showing that this allele may prevent the carcinogenic changes by stimulating the Apoptosis in the damaged epithelial cells. This may be the reason of low incidences of Gastric cancer in North India in spite of a relatively higher H. pylori infection thus possibly providing some explaination to Indian Enigma of Gastric Cancer (Pandey, 2010;Misra et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The changes caused by this organism at genetic level are not clear and therefore the present study was aimed to provide experimental evidence of relationship between H. pylori infection and gastric carcinogenesis by elucidating its relationship with p53 polymorphism at codon 72 and change in the rate of Apoptosis to elucidate the reasons for decreased prevalence of gastric cancer with H. pylori despite high rate of infection Ther aim of this study was to find the possible explanation of Indian enigma of gastric cancer (Singh and Ghosha, 2006;Pandey et al, 2010;Misra et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

Pandey¹,

Misra²,

Misra³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aim: P53, the most commonly mutated tumor suppressor gene in all types of human cancer, is involved in cell cycle arrest and control of apoptosis. Although p53 contains several polymorphic sites, the codon 72 polymorphism is by far more common. There are divergent reports but many studies suggest p53 pro/pro SNP may be associated with susceptibility to developing various cancers in different regions of the world. The present study aimed to find any correlation between H. pylori infection and progression of carcinogenesis, by studying apoptosis and the p53 gene in gastric biopsies from north Indian population. Materials and Methods: A total of 921 biopsies were collected and tested for prevalence of H. pylori by rapid urease test (RUT), imprint cytology and histology. Apoptosis was studied by the TUNEL method. Analysis of p53 gene polymorphism at codon 72 was accomplished by PCR using restriction enzyme BstU1. Observation: Out of 921 samples tested 56.7% (543) were H. pylori positive by the three techniques. The mean apoptotic index (AI) in the normal group was 2.12, while gastritis had the maximum 4.24 followed by gastric ulcer 2.28, gastropathy 2.22 and duodenal ulcer 2.08. Mean AI in cases with gastric cancer (1.72) was less than the normal group. The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% & 33.66%) as compared to p53 pro/pro variant (25.74%) inthe healthy population. Conclusions: The North Indian population harbors Arg or Pro/Arg SNP that is capable of withstanding stress conditions; this may be the reason of low incidence of gastric disease in spite of high infection with H. pylori. There was no significant association with H. pylori infection and AI. However, there is increased apoptosis in gastritis which may occur independent of H. pylori or p53 polymorphism.

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“…The prevalence of PU varies geographically and within individual countries. This was shown in India , the differences being attributed possibly to variation in H. pylori strains, host genetic makeup, environmental factors, and different infection rates in the population. A Brazilian study compared endoscopy records between 1997–2000 and 2007–2010.…”

Section: Peptic Ulcer Diseasementioning

confidence: 91%

Helicobacter pylori and Nonmalignant Diseases

Potamitis

Axon²

2015

Helicobacter

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Helicobacter pylori is responsible for most peptic ulcers, plays a role in functional dyspepsia and is thought by some to influence the course of gastroesophageal reflux disease. This article addresses recent studies that have been published in connection with these diseases. H. pylori-associated peptic ulcer is declining in prevalence but the incidence of perforation and bleeding remains high especially in the elderly. All H. pylori associated peptic ulcers should be treated by eradication of the infection. Dyspepsia is a common disorder that affects up to 25% of the population.

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Helicobacter pyloriand gastric cancer: Indian enigma

Cited by 42 publications

References 51 publications

Clinico - Demographic Profi Le of Gastric Cancer in Kashmir

Clinico - Demographic Profi Le of Gastric Cancer in Kashmir

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

Helicobacter pylori and Nonmalignant Diseases

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