<i>Helicobacter pylori</i> and gastric acid: an intimate and reciprocal relationship

Waldum, Helge L.; Kleveland, P. M.; Sørdal, Øystein

doi:10.1177/1756283x16663395

Cited by 66 publications

(68 citation statements)

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“…The human intestine harbors nearly 100 trillion bacteria that are essential for health . Helicobacter pylori ( H pylori ) is a pathogen of GI diseases that can survive in the gastric juice . Previous reports found that H pylori infection causes changes in the normal physiological state of the GI flora, mental disorders via the vagus nerve, and alterations in the CNS.…”

Section: Introductionmentioning

confidence: 99%

The relationship between Helicobacter pylori infection and depressive symptoms in the general population in China: The TCLSIH cohort study

Zheng

Kumari

et al. 2019

Helicobacter

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Background: Depressive symptoms are a common, debilitating, and costly public health issue. Helicobacter pylori (H pylori) infection cause changes in the normal physiological state of the gastrointestinal (GI) flora. Although the physiological state of the GI tract is closely related to mental disorders, few population studies have examined the relationship between H pylori infection and depressive symptoms in the general population. The aim of this study was to examine whether H pylori infection is related to depressive symptoms among the general adult population. Materials and Methods: This cross-sectional study included 5558 inhabitants of Tianjin, China. H pylori infection was diagnosed with the carbon 13 breath test.Depressive symptoms were assessed using the Chinese version of 20-item Self-rating Depression Scale (SDS) with three cutoffs (45, 48, and 50) to indicate elevated depressive symptoms. Multiple logistic regression analysis were conducted to assess the association between H pylori infection and depressive symptoms. Results:The prevalence of depressive symptoms (SDS ≥ 45) was 12.7% in men and 17.4% in women. In multivariable models, the odds ratios and 95% confidence interval of having depressive symptoms by H pylori infection were 1.25 (1.01-1.56), 1.46(1.11-1.91), and 1.46 (1.05-2.06) for three cutoffs: 45, 48, and 50 in women. However, no significant difference was found between H pylori infection and depressive symptoms in men. Conclusions:This study firstly suggested that H pylori infection was related to depressive symptoms in women in the general adult population. Further prospective studies or randomized trials are required to clarify the causality. K E Y W O R D Scross-sectional study, depressive symptoms, Helicobacter pylori

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Section: Introductionmentioning

confidence: 99%

The relationship between Helicobacter pylori infection and depressive symptoms in the general population in China: The TCLSIH cohort study

Zheng

Kumari

et al. 2019

Helicobacter

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“…Interestingly, host interactions with H. pylori will improve allergic diseases and inflammatory bowel disease, especially in children [22]. Moreover, childhood H. pylori infection seems to be prevalent, which may be explained partly by reduced gastric acidity [23]. This phenomenon is significantly associated with abundant Treg cells compared to adults [24].…”

Section: The Different Characters Of Immune Cells In Inflammationmentioning

confidence: 99%

Immune Response in H. pylori-Associated Gastritis and Gastric Cancer

Niu

Zhu

et al. 2020

Gastroenterology Research and Practice

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Helicobacter pylori (H. pylori) is the dominant member of the gastric microbiota and has infected more than half of the human population, of whom 5–15% develop gastric diseases ranging from gastritis and metaplasia to gastric cancer. These diseases always follow inflammation induced by cell surface and intracellular receptors and subsequent signaling, such as the NF-κB pathway and inflammasomes. Some types of immune cells are recruited to enforce an antibacterial response, which could be impeded by H. pylori virulence factors with or without a specific immune cell. Following decreased inflammation, neoplasm may appear with a little immune surveillance and may inhibit antitumor immunity. Therefore, the balance between H. pylori-associated inflammation and anti-inflammation is crucial for human health and remains to be determined. Here, we discuss multiple inflammation and immunoregulatory cells in gastritis and summarize the main immune evasion strategies employed by gastric cancer.

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“…Due to the living environment and eating habits of the Chinese people, the Helicobacter pylori infection rate is higher in China than in developed countries, with an average H. pylori infection rate of 54.76% . Studies have found that H. pylori infection is closely related to functional dyspepsia, peptic ulcer, gastric cancer, gastric mucosa‐associated lymphoma and a variety of chronic gastritis and other gastrointestinal diseases . Studies thus far have mainly focused on the pathogenesis, prevention and treatment of the variety of gastrointestinal diseases caused by H. pylori infection.…”

Section: Introductionmentioning

confidence: 99%