2014
DOI: 10.1089/scd.2013.0463
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Abstract: Skeletal development and cartilage formation require stringent regulation of gene expression for mesenchymal stem cells (MSCs) to progress through stages of differentiation. Since microRNAs (miRNAs) regulate biological processes, the objective of the present study was to identify novel miRNAs involved in the modulation of chondrogenesis. We performed miRNA profiling and identify miR-29a as being one of the most down-regulated miRNAs during the chondrogenesis. Using chromatin immunoprecipitation, we showed that… Show more

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Cited by 82 publications
(71 citation statements)
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“…Therefore, this regulatory relay may form a positive feedback loop to enhance chondrogenesis. In another study using human MSCs, miR-29a was identified as one of the most downregulated miRNAs during chondrogenesis [33]. Consistent with the aforementioned study, Sox9 was again found to downregulate miR-29a.…”
Section: Role Of Mirnas In Cartilage Developmentsupporting
confidence: 75%
“…Therefore, this regulatory relay may form a positive feedback loop to enhance chondrogenesis. In another study using human MSCs, miR-29a was identified as one of the most downregulated miRNAs during chondrogenesis [33]. Consistent with the aforementioned study, Sox9 was again found to downregulate miR-29a.…”
Section: Role Of Mirnas In Cartilage Developmentsupporting
confidence: 75%
“…The overexpression of miR-29a has down-regulated the expression of FOXO3A and chondrocyte-specific markers during MSCs chondrogenic differentiation. The data revealed that down-regulation of miR-29a, and up-regulation of FOXO3A are important in the chondrogenic differentiation of MSCs (Guerit et al, 2014). Hoxa2 was found to be decreased during the chondrogenic differentiation of MSCs, and forced over-expression of Hoxa2 resulted in inhibition of MSCs differentiation toward chondrocytes lineage (Seifert et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Accumulating evidence has demonstrated the involvement of miR-29 family members in maintaining the self-renewal characteristics of hematopoietic progenitor cells [14] and differentiation capacities of osteogenic [15], chondrogenic [16], and osteoclastogenic precursor cells [17]. miR-29a signaling reportedly inhibits adipogenic marker expression of hepatocytes and lipid accumulation in the liver of mice [18] and modulates high fat diet-mediated disturbance of energy metabolism [19].…”
Section: Introductionmentioning
confidence: 99%