<i>Eucommia ulmoides</i>Oliver Leaf Extract Increases Endogenous Antioxidant Activity in Type 2 Diabetic Mice

Park, Sun Ae; Choi, Myung‐Sook; Jung, Un Ju; Kim, Myung‐Joo; Kim, Dong Ju; Park, Hae-Mo; Park, Yong Bok; Lee, Mi-Kyung

doi:10.1089/jmf.2006.9.474

Cited by 85 publications

(56 citation statements)

References 30 publications

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“…Since most of the antidiabetic medications could have side effects (8), many studies have been conducted to identify natural substances that show antidiabetic activity with less side effects (22,27). Garlic and its products could be suitable candidates for antidiabetic agents via antioxidant effects (23).…”

Section: Discussionmentioning

confidence: 99%

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

Naderi

Mohaddes

Mohammadi

et al. 2015

Acta Physiologica Hungarica

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Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects of garlic (Allium sativum) were investigated in the blood and heart of streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats were randomly divided into four groups: control, garlic, diabetic, and diabetic+garlic. Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (50 mg/kg) in male rats. Rats were fed with raw fresh garlic homogenate (250 mg/kg) six days a week by gavage for a period of 6 weeks. At the end of the 6th week blood samples and heart tissues were collected and used for determination of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and histological evaluation. Induction of diabetes increased MDA levels in blood and homogenates of heart. In diabetic rats treated with garlic, MDA levels decreased in blood and heart homogenates. Treatment of diabetic rats with garlic increased SOD, GPX and CAT in blood and heart homogenates. Histopathological finding of the myocardial tissue confirmed a protective role for garlic in diabetic rats. Thus, the present study reveals that garlic may effectively modulate antioxidants status in the blood and heart of streptozotocin induced-diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

Naderi

Mohaddes

Mohammadi

et al. 2015

Acta Physiologica Hungarica

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“…Natural plant extracts. Eucommia ulmoides Oliver (Du-zhong) leaf extract significantly elevated plasma PON activity and lowered blood glucose concentrations when administered to type 2 diabetic (C57BL/6J-db/db) mice (262). When rats were fed with a diet containing 20% pistachio for 10 weeks, their HDL levels were increased, whereas their total cholesterol, LDL-cholesterol, and triglyceride levels were unaffected.…”

Section: E Dietary Factors and Lifestyle Factorsmentioning

confidence: 99%

The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

She

Chen

Yan

et al. 2012

Antioxidants & Redox Signaling

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The paraoxonase (PON) gene cluster contains three adjacent gene members, PON1, PON2, and PON3. Originating from the same fungus lactonase precursor, all of the three PON genes share high sequence identity and a similar b propeller protein structure. PON1 and PON3 are primarily expressed in the liver and secreted into the serum upon expression, whereas PON2 is ubiquitously expressed and remains inside the cell. Each PON member has high catalytic activity toward corresponding artificial organophosphate, and all exhibit activities to lactones. Therefore, all three members of the family are regarded as lactonases. Under physiological conditions, they act to degrade metabolites of polyunsaturated fatty acids and homocysteine (Hcy) thiolactone, among other compounds. By detoxifying both oxidized low-density lipoprotein and Hcy thiolactone, PONs protect against atherosclerosis and coronary artery diseases, as has been illustrated by many types of in vitro and in vivo experimental evidence. Clinical observations focusing on gene polymorphisms also indicate that PON1, PON2, and PON3 are protective against coronary artery disease. Many other conditions, such as diabetes, metabolic syndrome, and aging, have been shown to relate to PONs. The abundance and/or activity of PONs can be regulated by lipoproteins and their metabolites, biological macromolecules, pharmacological treatments, dietary factors, and lifestyle. In conclusion, both previous results and ongoing studies provide evidence, making the PON cluster a prospective target for the treatment of atherosclerosis. Antioxid. Redox Signal. 16, 597-632.

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“…Since most of antidiabetic medications could have side effects (2 7), many studies have been conducted to identify natural substances that show potent hypoglycemic activity with fewer side effects (28)(29)(30)(31). Eucommia ulmoides Oliver (Du-zhong) leaf (28,29), touchi extract (30), and Commelina communis (31) showed hypoglycemic activity in animal model of diabetes. Consumption of Du-zhong leaf extract for 6 weeks decreased blood glucose by 18.4% in db/db mice.…”

Section: Glycemic Controlmentioning

confidence: 99%

Effect of Garlic and Aged Black Garlic on Hyperglycemia and Dyslipidemia in Animal Model of Type 2 Diabetes Mellitus

Seo¹,

Gweon²,

Im³

et al. 2009

JFN

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Control of hyperglycemia and dyslipidemia is strongly correlated with decreased risk for cardiovascular disease, the most common and fatal diabetic complication. The purpose of this study is to determine the effects of garlic and aged black garlic on glycemic control and blood lipid profile in animal model of type 2 diabetes. Three week-old db/db mice (C57BL/Ks, n=21) were fed AIN-93G semipurified diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Fasting serum glucose, insulin, triglyceride, total cholesterol, and HDL-cholesterol and blood glycated hemoglobin were measured. Body weight and food intake of garlic and aged black garlic group were not significantly different from those of the control group. Fasting serum glucose and blood glycated hemoglobin levels were significantly decreased and insulin level was significantly increased in garlic group compared with control group (p<0.05). Consumption of aged black garlic significantly decreased homeostasis model assessment for insulin resistance (HOMA-IR) and tended to decrease serum glucose. Garlic consumption significantly decreased total cholesterol, while aged black garlic significantly reduced serum total cholesterol and triglyceride and increased HDL-cholesterol levels. These results suggest that garlic exerts hypoglycemic and hypocholesterolemic effect and aged black garlic improved insulin sensitivity and dyslipidemia in db/db mice.

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Eucommia ulmoidesOliver Leaf Extract Increases Endogenous Antioxidant Activity in Type 2 Diabetic Mice

Cited by 85 publications

References 30 publications

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

Effect of Garlic and Aged Black Garlic on Hyperglycemia and Dyslipidemia in Animal Model of Type 2 Diabetes Mellitus

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