<i>Cutibacterium acnes</i>
            in acne pathophysiology – the chicken or the egg?

Ochsendorf, Falk

doi:10.1111/bjd.18316

Cited by 5 publications

(7 citation statements)

References 11 publications

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“…25 Acne vulgaris is a complex disease with multiple interacting pathogenic factors, and its pathogenesis is still not completely understood. 26 The current animal models for acne pharmacodynamic research, such as the ear swelling model and the rabbit ear anti-keratinization model, these models primarily focus on a single pathogenic factor and are limited in their ability to fully reflect the pathological characteristics of the disease, particularly the interaction of multiple pathogenic factors, which is similar to that observed in human acne. To gain a more comprehensive understanding of the pathogenesis of acne and to better assess the effectiveness of anti-acne drugs, it is imperative to develop an animal model that more closely reflects the pathogenesis of human acne.…”

Section: Discussionmentioning

confidence: 99%

Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology

Sun

Ren

et al. 2023

Experimental Dermatology

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Acne vulgaris is a disorder of the pilosebaceous unit that is primarily caused by hyperseborrhoea, colonization with Propionibacterium acnes, hyperkeratosis and an inflammatory response. Existing pharmacodynamic assessment methods primarily focus on a single causative factor at a certain time point, making it difficult to assess multiple factors simultaneously in real time. Therefore, it is crucial to establish a dynamic and nondestructive method for the assessment of acne in vivo. This study utilized four‐dimensional optical imaging techniques to assess the pathogenic factors and pathological progression of acne. LSCI was employed to measure blood flow; TPEF was used to observe inflammatory changes (NAD(P)H) in epidermal granular layer cells and structural changes in collagen fibres in the dermal layer. Additionally, the dermatoscope was used to investigate the micro‐characterization of the lesions. We observed that the epidermis in the lesion area was thickened, hair follicles were keratinized, and there was obvious inflammation and blood flow aggregation by optical imaging technology. Based on these findings, the pathological progression of this acne model could be divided into the inflammation phase, accompanied by bacterial colonization, and the reparative phase. These results provide a new perspective for the assessment of acne and offer an experimental basis for the selection of precise drugs for clinical use.

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Section: Discussionmentioning

confidence: 99%

Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology

Sun

Ren

et al. 2023

Experimental Dermatology

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“…These factors are interconnected, such as due to the increased sebum production where many lipophilic bacteria like Cutibacterium acnes proliferate. These bacteria produce free fatty acids due to the lipase enzyme, which provokes the cells to secrete IL-1α and other cytokines to induce inflammatory responses and contribute to acne production [ 7 ]. According to earlier studies, C. acnes were responsible for acne; however, recent studies have shown that dysbiosis of facial microbiota plays a significant role in acne production [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Stabilization of Acne Vulgaris-Associated Microbial Dysbiosis with 2% Supramolecular Salicylic Acid

et al. 2023

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Facial microbiota dysbiosis is an important factor in causing acne vulgaris. The present study aimed to analyze the effect of 2% Supramolecular Salicylic Acid (SSA) on acne-associated facial bacteria. In the current study, 30 acne vulgaris patients (treated with 2% SSA for eight weeks) and ten volunteers with no facial acne were selected. Samples from acne patients (before and after treatment) and volunteers (not treated) were analyzed via high throughput sequencing, Deblur algorithm, and R microbiome package. After treatment with 2% SSA, the total lesion count and global acne grading system (GAGS) score reduced significantly (p < 0.001). Metagenomic sequencing analysis revealed that the pre-treated acne group had low α and deviated β diversity compared to the control and post-treated acne groups. Due to the treatment with 2% SSA, α diversity index was increased and β diversity was stabilized significantly (p < 0.001). The relative abundance of bacterial genera in the pre-treated acne group was uneven and had a high proportion of Staphylococcus, Ralstonia, and Streptococcus. The proportion of these three genera was significantly decreased in the post-treated group, and overall bacteria genera distribution tends toward the healthy individual. It is concluded that 2% SSA normalizes the microbial communities associated with the skin.

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“…Presently, through the popularization of high‐throughput sequencing technology, 10–12 researchers have found that the incidence of acne is related to microbiome diversity 13 . Other microbes, including Staphylococcus , 14 Demodex , 15,16 and Malassezia , 17 may be involved in the pathogenesis of acne, making the status of skin microflora in the pathogenesis of acne unclear 8,18,19 …”

Section: Introductionmentioning

confidence: 99%

“…13 Other microbes, including Staphylococcus, 14 Demodex, 15,16 and Malassezia, 17 may be involved in the pathogenesis of acne, making the status of skin microflora in the pathogenesis of acne unclear. 8,18,19 Photodynamic therapy (PDT) combines a photosensitizer and light source to generate reactive oxygen species. 20 PDT is a safe and effective method for the treatment of severe acne.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy treats acne by altering the composition of the skin microbiota

Guo

Yuan

et al. 2022

Skin Research and Technology

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Background Acne is the eighth‐most prevalent inflammatory skin disease with no optimal treatment. Photodynamic therapy (PDT) is an effective treatment for severe acne. Aims The effect of PDT on the composition and diversity of skin microflora in severe acne patients was studied. Materials and Methods A total of 18 patients with severe acne and 8 healthy individuals were selected for this study. Patients were treated with 5‐aminolevulinic acid‐mediated PDT once a week three times in total; the skin microbiome was measured by 16S ribosomal RNA gene sequencing before and after treatment (1 week after each PDT). Results The microflora composition was different between healthy controls and patients, and between patients before and after treatment. Alpha diversity indices were lower in patients than those in control. There were 15 bacterial genera with high relative abundance that had noticeable changes during treatment. At the genus level,particularly Cutibacterium acnes (C. acnes formerly Propionibacterium acnes), there was no statistically significant difference among different group. The abundances of Staphylococcus epidermidis and Staphylococcus aureus were low. Discussion The microbial composition is different between severe acne patients acne patients and healthy individuals. The therapeutic efficacy of severe acne treated with PDT is associated with the composition and diversity of skin microbiota. Conclusion The skin microbial composition changes after PDT treatment. PDT is an effective method for the treatment of severe acne.

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Cutibacterium acnes in acne pathophysiology – the chicken or the egg?

Abstract: Linked Article: Ramasamy et al. Br J Dermatol 2019; 181:691–699.

Cited by 5 publications

References 11 publications

Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology

Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology

Stabilization of Acne Vulgaris-Associated Microbial Dysbiosis with 2% Supramolecular Salicylic Acid

Photodynamic therapy treats acne by altering the composition of the skin microbiota

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