<i>Cuminum cyminum</i> fruits as source of luteolin- 7-<i>O</i>-glucoside, potent cytotoxic flavonoid against breast cancer cell lines

Goodarzi, Saied; Tabatabaei, Mir Javad; Jafari, Razieh Mohammad; Shemirani, Farzaneh; Tavakoli, Sina; Mofasseri, Mansur; Tofighi, Zahra

doi:10.1080/14786419.2018.1519824

Cited by 54 publications

(41 citation statements)

References 17 publications

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“…A study using human liver cancer cells has shown thatluteolin-7-O-glucoside causes cancer cell death by inducing cell cycle arrest at G2/M phase, and the effect is mediated by increased production of free radical and phosphorylation of JNK [34]. Moreover, a recent study has shown that luteolin-7-O-glucoside extracted from Cuminum cyminum has cytotoxic effects against breast cancer cells, which makes luteolin-7-O-glucoside a potential chemotherapeutic agent [35]. In contrast, it has been found that luteolin-7-O-glucoside exerts anti-apoptotic effects on cardiomyocytes that are treated with angiotensin II to develop cardiac hypertrophy [36].…”

Section: Discussionmentioning

confidence: 99%

Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

et al. 2020

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Oral squamous cell carcinoma is the sixth most common type of cancer globally, which is associated with high rates of cancer-related deaths. Metastasis to distant organs is the main reason behind worst prognostic outcome of oral cancer. In the present study, we aimed at evaluating the effects of a natural plant flavonoid, luteolin-7-O-glucoside, on oral cancer cell migration and invasion. The study findings showed that in addition to preventing cell proliferation, luteolin-7-O-glucoside caused a significant reduction in oral cancer cell migration and invasion. Mechanistically, luteolin-7-O-glucoside caused a reduction in cancer metastasis by reducing p38 phosphorylation and downregulating matrix metalloproteinase (MMP)-2 expression. Using a p38 inhibitor, SB203580, we proved that luteolin-7-O-glucoside exerts anti-migratory effects by suppressing p38-mediated increased expression of MMP-2. This is the first study to demonstrate the luteolin-7-O-glucoside inhibits cell migration and invasion by regulating MMP-2 expression and extracellular signal-regulated kinase pathway in human oral cancer cell. The study identifies luteolin-7-O-glucoside as a potential anti-cancer candidate that can be utilized clinically for improving oral cancer prognosis.

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Section: Discussionmentioning

confidence: 99%

Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

et al. 2020

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“…The content in WP was the lowest; therefore, WP could not restrain Hela cells. Luteolin-4′-O-glucoside was also reported to possess a strong inhibitory efficacy on Hela cells [20]. Moreover, EAP contained more luteolin-4′-O-glucoside than BP (Table 1); hence, the restrain effect of EAP was the strongest.…”

Section: Analysis Of Anti-tumor Activity In Different Extraction Phasesmentioning

confidence: 97%

Phenolic Composition, Antioxidant and Anticancer Potentials of Extracts from Rosa banksiae Ait. Flowers

et al. 2020

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Rosa banksiae Ait. (R. banksiae) is a traditional Chinese folk medicine and an ornamental plant. Most previous studies have focused on cultivation and utilization while there are few research papers on the pharmacological activity of R. banksiae. This study aimed to get a better understanding of R. banksiae by extracting polyphenols with fractionated extraction technology. The results showed that ethyl acetate phase (EAP) contained the most polyphenols, while water phase (WP) had the least. HPLC analysis indicated that rutin and luteolin-4′-O-glucoside existed in the EAP and butanol phase (BP), but quercetin was only detected in the EAP. Six phenolic compositions were not detected in WB. The antioxidant and anti-tumor abilities of the EAP and BP were excellent. The results revealed that R. banksiae possessed a great antioxidant capacity and was rich in polyphenols, thus indicating R. banksiae was suitable for being a natural antioxidant and an abundant source of polyphenols.

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“…Various cumin seed extracts exhibited anticancer and neuro-protective effects against IMR32 human neuroblastoma cell lines [ 166 ]. Different flavonoids have been purified and identified from C. cyminum and showed anticancer potency against breast cancer MCF-7 cell line [ 167 ].…”

Section: Herbal Infusions Antioxidant and Anticancer Capacitiesmentioning

confidence: 99%

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

et al. 2020

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The release of reactive oxygen species (ROS) and oxidative stress is associated with the development of many ailments, including cardiovascular diseases, diabetes and cancer. The causal link between oxidative stress and cancer is well established and antioxidants are suggested as a protective mechanism against cancer development. Recently, an increase in the consumption of antioxidant supplements was observed globally. The main sources of these antioxidants include fruits, vegetables, and beverage. Herbal infusions are highly popular beverages consumed daily for different reasons. Studies showed the potent antioxidant effects of plants used in the preparation of some herbal infusions. Such herbal infusions represent an important source of antioxidants and can be used as a dietary protection against cancer. However, uncontrolled consumption of herbal infusions may cause toxicity and reduced antioxidant activity. In this review, eleven widely consumed herbal infusions were evaluated for their antioxidant capacities, anticancer potential and possible toxicity. These herbal infusions are highly popular and consumed as daily drinks in different countries. Studies discussed in this review will provide a solid ground for researchers to have better understanding of the use of herbal infusions to reduce oxidative stress and as protective supplements against cancer development.

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Cuminum cyminum fruits as source of luteolin- 7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines

Cited by 54 publications

References 17 publications

Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

Phenolic Composition, Antioxidant and Anticancer Potentials of Extracts from Rosa banksiae Ait. Flowers

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

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