“
            <i>Candidatus</i>
            Helicobacter heilmannii” from a Cynomolgus Monkey Induces Gastric Mucosa-Associated Lymphoid Tissue Lymphomas in C57BL/6 Mice

Nakamura, Masahiko; Murayama, Somay Yamagata; Shinmoto, Hiroshi; Sekiya, Yukie; Eguchi, M.; Takahashi, Shinichi; Nishikawa, Kaori; Takahashi, Takuya; Matsumoto, Tsukasa; Yamada, Hideaki; Hibi, Toshifumi; Tsuchimoto, Kanji; Matsui, Hidenori

doi:10.1128/iai.01459-06

Cited by 67 publications

(104 citation statements)

References 27 publications

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“…develop MALT lymphoma more frequently than those with H. pylori [56] . Although in the previous studies there was not a clear identification of the bacteria at a species level, in experimentally infected animal models the administration of H. heilmannii s.s.-positive gastric biopsy homogenates to BALB/c and to C57BL/6 mice induced gastric MALT lymphoma [57][58][59] . Furthermore, infection with pure bacterial isolates of H. felis [60][61][62] and of H. suis [63] were shown to induce gastric MALT lymphoma-like lesions in the BALB/c and in the Mongolian gerbil models, respectively.…”

Section: H Heilmannii Sl-associated Diseases In Humansmentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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Section: H Heilmannii Sl-associated Diseases In Humansmentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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“…suis has been demonstrated in the stomachs of two mandrill monkeys (Papio sphinx), two cynomolgus monkeys (Macaca fasicularis), and one rhesus macaque (Macaca mulatta) from a zoo (167). One isolate, first described as "H. heilmannii" (114) and later identified as "Candidatus Helicobacter heilmannii" (158), was obtained by intragastric inoculation of mice with gastric tissue from a cynomolgus monkey (Macaca fascicularis). No information on the pathogenic significance of these Helicobacter species for nonhuman primates is available, and the source of infection remains to be determined.…”

Section: Bronsdon Et Al (24) Isolated and Described H Nemestrinae Fmentioning

confidence: 99%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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“…176 Finally, infection of C57BL/6 mice with Candidatus H. heilmannii resulted in the development of gastric MALT lymphoma in 100% of the mice after six months. 178 It is noted that in all these infection protocols, the diagnosis of MZBCLs was based on morphological grounds alone, i.e. the presence of centrocyte-like cells and lympho-epithelial lesions, but not on the assessment of monoclonality by Ig gene rearrangement assays nor on any other molecular genetic analyses.…”

Section: Mouse Models Of Marginal Zone B-cell Lymphomamentioning

confidence: 99%

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Bende¹,

Maldegem²,

Noesel³

2009

Haematologica

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Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.Key words: B-cell non-Hodgkin's lymphoma, extranodal marginal zone B-cell lymphoma, immunoglobulin, B-cell antigen receptor, inflammation, lymphoid tissue neogenesis. Haematologica 2009;94:1109-1123. doi:10.3324/haematol.2009 This is an open-access paper. Citation: Bende RJ, van Maldegem F, and van Noesel CJM. Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B cell lymphomas. ABSTRACT Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

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“ Candidatus Helicobacter heilmannii” from a Cynomolgus Monkey Induces Gastric Mucosa-Associated Lymphoid Tissue Lymphomas in C57BL/6 Mice

Cited by 67 publications

References 27 publications

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

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