<i>C. elegans:</i> a sensible model for sensory biology

Iliff, Adam J.; Xu, X.Z. Shawn

doi:10.1080/01677063.2020.1823386

Cited by 25 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The worm’s genome contains 97 million base pairs and approximately 20,000 genes, about 40% of which are analogous to genes found in humans ( Consortium, 1998 ). C. elegans have 302 neurons and 56 glia, allowing C. elegans to react to changes in lighting, touch, temperature, salinity, and chemical gradients ( Iliff and Xu, 2020 ). C. elegans uses temperature, oxygen, and salt-sensing neurons to detect and avoid CO 2 .…”

Section: Caenorhabditis Elegansmentioning

confidence: 99%

The utility of alternative models in particulate matter air pollution toxicology

Smoot

Padilla²,

Farraj³

2022

Current Research in Toxicology

View full text Add to dashboard Cite

Section: Caenorhabditis Elegansmentioning

confidence: 99%

The utility of alternative models in particulate matter air pollution toxicology

Smoot

Padilla²,

Farraj³

2022

Current Research in Toxicology

View full text Add to dashboard Cite

“…Sensorimotor processing in C. elegans originates in primary sensory neurons that detect odorants, tastants, touch, temperature, and more ( Iliff and Xu, 2020 ). Each of the 16 chemosensory neuron pairs expresses a multitude of chemoreceptors, which are predominantly G-protein-coupled receptors (GPCRs) ( Ferkey et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior

McLachlan

Kramer

Dua

et al. 2022

eLife

View full text Add to dashboard Cite

Animals must weigh competing needs and states to generate adaptive behavioral responses to the environment. Sensorimotor circuits are thus tasked with integrating diverse external and internal cues relevant to these needs to generate context-appropriate behaviors. However, the mechanisms that underlie this integration are largely unknown. Here, we show that a wide range of states and stimuli converge upon a single Caenorhabditis elegans olfactory neuron to modulate food-seeking behavior. Using an unbiased ribotagging approach, we find that the expression of olfactory receptor genes in the AWA olfactory neuron is influenced by a wide array of states and stimuli, including feeding state, physiological stress, and recent sensory cues. We identify odorants that activate these state-dependent olfactory receptors and show that altered expression of these receptors influences food-seeking and foraging. Further, we dissect the molecular and neural circuit pathways through which external sensory information and internal nutritional state are integrated by AWA. This reveals a modular organization in which sensory and state-related signals arising from different cell types in the body converge on AWA and independently control chemoreceptor expression. The synthesis of these signals by AWA allows animals to generate sensorimotor responses that reflect the animal’s overall state. Our findings suggest a general model in which sensory- and state-dependent transcriptional changes at the sensory periphery modulate animals’ sensorimotor responses to meet their ongoing needs and states.

show abstract

“…Many animals rely on olfaction for their survival. The nematode C. elegans has a refined sense of smell to finely detect changes in odorant concentrations in its natural habitat to exhibit chemotaxis toward bacteria and its food [ 55 , 56 ]. C. elegans has ~1200 olfactory receptor-like genes (~800 for dogs) and approaches a preferred odor while moving away from a disliked odor [ 57 ].…”

Section: Caenorhabditis Elegans As a Powerful Biosensor For ...mentioning

confidence: 99%

C. elegans as a Powerful Tool for Cancer Screening

Luccio¹,

Morishita²,

Hirotsu³

2022

Biomedicines

View full text Add to dashboard Cite

Regular cancer screening is critical for early cancer detection. Cancer screening tends to be burdensome, invasive, and expensive, especially for a comprehensive multi-organ check. Improving the rate and effectiveness of routine cancer screenings remain a challenge in health care. Multi-cancer early detection (MCED) is an exciting concept and a potentially effective solution for addressing current issues with routine cancer screening. In recent years, several technologies have matured for MCED, such as identifying cell-free tumor DNA in blood or using organisms such as Caenorhabditis elegans as a tool for early cancer detection. In Japan, N-NOSE is a commercially available multi-cancer detection test based on the chemotaxis of C. elegans using a urine sample showing 87.5% sensitivity and 90.2% specificity. In this review, we focus on using C. elegans as a powerful biosensor for universal cancer screening. We review N-NOSE clinical research results, spotlighting it as an effective primary cancer screening test.

show abstract

C. elegans: a sensible model for sensory biology

Cited by 25 publications

References 34 publications

The utility of alternative models in particulate matter air pollution toxicology

The utility of alternative models in particulate matter air pollution toxicology

Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior

C. elegans as a Powerful Tool for Cancer Screening

Contact Info

Product

Resources

About