Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment
Dmitry A Afonin,
Evgeny S Gerasimov,
Ingrid Škodová-Sveráková
et al.
Abstract:The canonical stop codons of the nuclear genome of the trypanosomatid Blastocrithidia nonstop are recoded. Here, we investigated the effect of this recoding on the mitochondrial genome and gene expression. Trypanosomatids possess a single mitochondrion and protein-coding transcripts of this genome require RNA editing in order to generate open reading frames of many transcripts encoded as ‘cryptogenes’. Small RNAs that can number in the hundreds direct editing and produce a mitochondrial transcriptome of unusua… Show more
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