2022
DOI: 10.1039/d1fo04446j
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Abstract: Oxidative stress and gut dysbiosis are important risk factors for hypertension. In this study, the preventive effect of Bifidobacterium longum CCFM752 (CCFM752) on hypertension was evaluated. 5-week-old spontaneously hypertensive rats...

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Cited by 10 publications
(4 citation statements)
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“…The present study found that oxidative stress did exist in SHR, and irbesartan, L. johnsonii or L. reuteri could significantly restore related oxides such as MDA, SOD, GSH, and CAT. Recent study has shown that Lactobacillus was positively associated with serum CAT activity, while Turicibacter was negatively connected with serum CAT activity [33]. These results suggested that the irbesartan decreased inflammatory cytokines and oxidative stress by regulating gut microbial ecology.…”
Section: Discussionmentioning
confidence: 85%
“…The present study found that oxidative stress did exist in SHR, and irbesartan, L. johnsonii or L. reuteri could significantly restore related oxides such as MDA, SOD, GSH, and CAT. Recent study has shown that Lactobacillus was positively associated with serum CAT activity, while Turicibacter was negatively connected with serum CAT activity [33]. These results suggested that the irbesartan decreased inflammatory cytokines and oxidative stress by regulating gut microbial ecology.…”
Section: Discussionmentioning
confidence: 85%
“…Bifidobacterium was found to be associated with a lower risk of PE, which is consistent with the results of our study [ 18 , 20 ]. Bifidobacterium , as a probiotic, has been widely reported to have a protective effect on cardiovascular [ 47 ] and metabolic diseases [ 48 ]. Consistent with previous studies [ 20 , 21 , 45 ], we also found that Lachnospiraceae (NK4A136 group) , butyrate-producing bacteria [ 49 ], reduced the risk of PE.…”
Section: Discussionmentioning
confidence: 99%
“…It has become a general agreement that there is a tight connection of gut microbiota with blood pressure regulation under the confirmation of many animal models, including spontaneously hypertensive rats (SHR), Ang II–induced hypertensive rats, and Dahl-salt sensitive rats [ 99 , 100 , 101 , 102 , 103 ]. Studies reported that Bifidobacteria could increase the activity of nitric oxide synthase (eNOS) while decreasing the activity of serum catalase [ 104 ]. Emerging evidence figured out that gut microbiota is involved in neuroinflammation mediated hypertension.…”
Section: Imbalance Of Gut Microbes and Cvdmentioning
confidence: 99%