<i>BDNF</i> Val66Met and cognition: all, none, or some? A meta‐analysis of the genetic association

Mandelman, Samuel D.; Grigorenko, Elena L.

doi:10.1111/j.1601-183x.2011.00738.x

Cited by 119 publications

(105 citation statements)

References 63 publications

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“…9 However, recent meta-analyses investigating the relationship between the functional BDNF Val66Met polymorphism and performance on memory tasks have suggested heterogeneity in odds ratios among subjects. 3,10 For example, some genetic association studies found impaired episodic memory performance in BDNF Met allele carriers compared to Val/Val homozygotes, [11][12][13] whereas other reports found no effect of the BDNF Val66Met polymorphism on memory.…”

Section: Introductionmentioning

confidence: 99%

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

Azeredo

Nardi

Levandowski

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged 4 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.

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Section: Introductionmentioning

confidence: 99%

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

Azeredo

Nardi

Levandowski

et al. 2017

Rev. Bras. Psiquiatr.

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“…Recommendations for future research include replication in larger samples of mixed race participants in which population stratification is corrected for and in which the Met66Met genotype is better represented (Notaras et al, 2015). Furthermore, variation across the BDNF gene would be useful to consider (Mandelman & Grigorenko, 2012). Additionally, the effect of other genetic variants, in conjunction with the BDNF Val66Met polymorphism, should be explored given findings of an epistatic effect between BDNF and the serotonin transporter genes (Martinowich & Lu, 2008; Pezawas et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

No gene-by-environment interaction of BDNF Val66Met polymorphism and childhood maltreatment on anxiety sensitivity in a mixed race adolescent sample

Martin

Hemmings

Kidd

et al. 2018

European Journal of Psychotraumatology

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Background: Anxiety disorders in youth are attributable to multiple causal mechanisms, comprising biological vulnerabilities, such as genetics and temperament, and unfavourable environmental influences, such as childhood maltreatment (CM).Objective: A gene-environment (G x E) interaction study was conducted to determine the interactive effect of the BDNF Val66Met polymorphism and CM to increase susceptibility to anxiety sensitivity (AS) in a sample of mixed race adolescents.Method: Participants (n = 308, mean age = 15.8 years) who were all secondary school students and who completed measures for AS and CM were genotyped for the BDNF Val66Met polymorphism. Hierarchical multiple regression analysis was conducted to assess G x E influences on AS. Age and gender were included in the models as covariates as age was significantly associated with AS total score (p < .05), and females had significantly higher AS scores than males (p < .05).Results: A main effect of CM on AS was evident (p < .05), however, no main effect of BDNF genotype on AS was observed (p > .05). A non-significant G x E effect on AS was revealed (p < .05).Conclusions: Our results suggest that CM does not have a moderating role in the relationship between the BDNF Val66Met genotype and the increased risk of anxiety-related phenotypes, such as AS. Given the exploratory nature of this study, findings require replication in larger samples and adjustment for population stratification to further explore the role of BDNF Val66Met and CM on AS in mixed race adolescents.

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“…However, several studies have investigated the effect of BDNF val66met on cognition and the results are mixed. A recent meta-analysis could not establish any significant influence of BDNF val66met on general cognitive ability, memory, executive function, visual processing skills, or cognitive fluency (Mandelman & Grigorenko, 2012). However, this meta-analysis did not permit an analysis of age stratifying effects on the association between the BDNF val66met and cognition.…”

Section: Bdnf and Odor Identificationmentioning

confidence: 96%

“…Hence, the overall pattern of findings regarding the BDNF val66met as a candidate gene for cognition presents a complex and conflicting pattern of results. A recent meta-analysis did not establish significant associations for the genotype and any of the included phenotypes, such as general cognitive ability, memory, executive functions, visual processing skills or verbal fluency (Mandelman & Grigorenko, 2012). However, this meta-analysis did not take age or sex into account to stratify for any effects on the association between the BDNF val66met polymorphism and cognition.…”

Section: Bdnf and Cognitionmentioning

confidence: 99%

Olfactory Function: The Influence of Demographic, Cognitive, and Genetic factors

Hedner¹

2013

PsycEXTRA Dataset

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Olfactory function is affected by demographic, cognitive, and genetic factors. In the present thesis, three empirical studies investigated individual differences in olfactory ability. Study I explored demographic and cognitive correlates in common olfactory tasks; odor detection, odor discrimination, and odor identification. The results indicated that old age influenced performance negatively in all tasks, and that semantic memory proficiency and executive functioning were related to odor discrimination and odor identification performance. No cognitive influence was observed for measurements of olfactory threshold. Using population-based data, Study II investigated a potential influence of the ApoE gene on olfactory identification after controlling for health status, semantic memory, and preclinical and clinical dementia. The main finding was that the ApoE-ɛ4 allele interacted with age, such that older ɛ4-carriers had an impaired odor identification performance relative to older non-carriers. Importantly, the negative ApoE-ɛ4 effect on olfactory proficiency was independent of clinical dementia conversion within five years. Study III investigated the effects of the BDNF val66met polymorphism on olfactory change over a five-year interval, in a communitydwelling sample of young and old age cohorts. The results showed that agerelated decline in olfactory identification was influenced by the BDNF val66met. In middle-aged subjects, no effect of BDNF val66met was observed although older val homozygote carriers showed a selectively larger olfactory decline than the older met carriers. Overall, results suggest that the relative influence of demographic and cognitive factors vary across different olfactory tasks and that two genes (ApoE and BDNF) impact age-related deficits in odor identification. Potential theoretical and practical implications of the findings are discussed as well as potential limitations of association studies in genomics research.

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BDNF Val66Met and cognition: all, none, or some? A meta‐analysis of the genetic association

Cited by 119 publications

References 63 publications

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

No gene-by-environment interaction of BDNF Val66Met polymorphism and childhood maltreatment on anxiety sensitivity in a mixed race adolescent sample

Olfactory Function: The Influence of Demographic, Cognitive, and Genetic factors

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