Hystological paraspinal muscle comparison between curve concavity and convexity in adolescent idiopathic scoliosis

Wajchenberg, Marcelo; Luciano, Rafael Paiva; Martins, Délio Eulálio; Rodrigues, Luciano Miler Reis; Puertas, Eduardo Barros; Cohen, Moisés; Curto, David Del; Oliveira, Acary Souza Bullé; Schmidt, Beny

doi:10.1186/1748-7161-9-s1-o12

Cited by 4 publications

(5 citation statements)

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“…Our results are in agreement with the previous histologic studies. [20] However, the results disagree with those of Zoabli G, et al, 2007 [22], which found a larger back muscle volume along the concave side compared with the convex side at the apex. In this study, there was strong agreement between the CT and MRI as regard the grade of muscle atrophy.…”

Section: Discussioncontrasting

confidence: 76%

“…[11] Idiopathic scoliosis (AIS) is usually more evident after puberty due to progressive axial growth. [20] Previous studies revealed that idiopathic scoliosis is associated with abnormalities in ber composition of the back muscles that result in muscle dysfunction. [21] Histologic studies proved that these changes are more evident on the concave side of the scoliotic curve.…”

Section: Introductionmentioning

confidence: 99%

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Asymmetrical radiological changes in the Paraspinal muscles in patients with idiopathic scoliosis: Prospective study

Zaghloul

Sobh

Deniwar

et al. 2022

Preprint

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ObjectivesThe aim of this study is to assess the CT and MRI appearance of theparaspinous muscles in patients with idiopathic scoliosis comparing both the convex and concave sides of the curve. The relation between the degrees of muscular abnormality and the Cobb angle is also assessed.Methods18 patients with idiopathic scoliosis were referred to Mansoura university hospital clinics in the period from September 2015 to February 2017. This observational prospective study includes patients with idiopathic scoliosis. Patients with secondary scoliosis due to other abnormalities were not included in this study. Verbal consent was obtained from the patient’s parents and institutional Board review acceptance at Mansoura University was done.ResultsBoth MRI and CT demonstrated the atrophy of the paraspinous muscles in patients with AIS in the form of reduction in the size of the muscle fibers, T1 & T2 hyperintenities within the muscle fibers by MRI and low density within the muscles fibers by CT as well as widening of the fatty spaces between the muscle bundles. Assessing the paraspinal muscles along the whole spine, we found that in all patients, the atrophic changes were more pronounced at the apex of the curve.ConclusionCT and MRI are effective non-invasive modalities to assess the changes in the paraspinal muscles. They demonstrate atrophic changes and fatty degeneration of the paraspinal muscles, more evident at the concave side of the apex of the primary curve. The degree of fatty degeneration is proportional with the Cobb’s angle.

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Section: Discussioncontrasting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Asymmetrical radiological changes in the Paraspinal muscles in patients with idiopathic scoliosis: Prospective study

Zaghloul

Sobh

Deniwar

et al. 2022

Preprint

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“…Such overexpression of b-catenin in AIS could lead to lower bone mineralization, resulting in poorer mechanical bone strength during pubertal growth spurt, and vulnerability to 3-D deformation of the spine in the presence of other predisposing factors (1). We speculate that the overexpression of b-catenin in AIS osteoblasts may also affect other tissues involved in spinal deformation via paracrine crosstalk, such as the vertebral growth plate (48,49) and paraspinal muscle abnormalities (50)(51)(52). Our findings (Fig.…”

Section: Discussionmentioning

confidence: 65%

Aberrant miR‐145–5p/β‐catenin signal impairs osteocyte function in adolescent idiopathic scoliosis

et al. 2018

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Recently, noncoding RNAs have been thought to play important roles in the sporadic occurrence of spinal deformity of adolescent idiopathic scoliosis (AIS). As a prognostic factor for curve progression, low bone mass has been hypothesized to crosstalk with AIS pathogenesis. Abnormal osteoblasts activities are reported in AIS without a clear mechanism. In this study, bone biopsies from patients with AIS and control subjects and the primary osteoblasts derived from those samples were used to identify the potential microRNA (miRNA) candidates that interfere with osteoblasts and osteocytes function. Microarray analysis identified miRNA-145-5p (miR-145) as a potential upstream regulator. miR-145 and β-catenin mRNA ( CTNNB1) were overexpressed in AIS bone tissues and primary osteoblasts, and their expression correlated positively in AIS. Knockdown of miR-145 restored impaired osteocyte activity through the down-regulation of active β-catenin expression and its transcriptional activity. Significant negative correlations between circulating miR-145 and serum sclerostin, osteopontin, and osteoprotegerin were noted in patients with AIS, which was in line with our cellular findings. This is the first study to demonstrate the effect of aberrant miRNA expression and its effect on osteocyte function in AIS, which may contribute to the low bone mass. Our findings also provide insight into the development of circulating microRNAs as a bone quality biomarker or even a prognostic biomarker for AIS.-Zhang, J., Chen, H., Leung, R. K. K., Choy, K. W., Lam, T. P., Ng, B. K. W., Qiu,Y., Feng, J. Q., Cheng, J. C. Y., Lee, W. Y. W. Aberrant miR-145-5p/β-catenin signal impairs osteocyte function in adolescent idiopathic scoliosis.

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“…Left and right side of the trunk muscles' static endurance results ratio is considered as norm when ratio is 1. Normally, muscles' static endurance of the one side is higher than of the other side, depending on the prevailing arm [13]. Trunk muscles' static endurance results ratios are shown in the Table 2.…”

Section: Resultsmentioning

confidence: 98%

Effects of the Schroth Method for Trunk Muscles’ Static Endurance and Spine Mobility in Girls With Idiopathic Scoliosis

et al. 2017

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The prevalence of scoliosis in the paediatric population is increasing every year. The treatment of idiopathic scoliosis in Lithuania is based on traditional physical therapy, and it is not always the most effective. Schroth method recently is widely globally used evidence-based conservative scoliosis treatment method. The aim of the study was to assess the effects of the Schroth method treatment for trunk muscles’ static endurance and spine mobility in girls with idiopathic scoliosis. The study was conducted in 2016-2017 at the Physical Medicine and Rehabilitation Centre, Children’s Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos. In the study participated 50 girls aged 9-17 years with idiopathic scoliosis. The patients were divided into two groups: the study group (n = 25) and the control group (n = 25). Schroth treatment method for the study group and a traditional physiotherapy for the control group were used. For patients were applied 10 procedures of physiotherapy (for 30 minutes, 5 times a week). The study showed that trunk muscles’ static endurance results after rehabilitation were significantly higher in the study group than in the control group (p<0.05). The analysis of the average changes in the results between the groups revealed that in the study group the results of abdominal muscles (16.08 s more), left side trunk muscles (6.98 s more), and right side trunk muscles (7.84 s more) had changed significantly. Results of spine mobility significantly improved in both groups after rehabilitation (p<0.05). Trunk flexion amplitude estimated to have significantly greater improvement in the study group. The treatment using Schroth method had significantly improved the indicators of trunk muscles’ static endurance and mobility of the spine during spinal flexion. When compare the results inside the groups, the significant change was shown in the majority of spine and posture-related parameters in the study group. Special physiotherapy, especially Schroth method for children with idiopathic scoliosis have been shown to be an effective conservative treatment for scoliosis.

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Hystological paraspinal muscle comparison between curve concavity and convexity in adolescent idiopathic scoliosis

Cited by 4 publications

References 0 publications

Asymmetrical radiological changes in the Paraspinal muscles in patients with idiopathic scoliosis: Prospective study

Asymmetrical radiological changes in the Paraspinal muscles in patients with idiopathic scoliosis: Prospective study

Aberrant miR‐145–5p/β‐catenin signal impairs osteocyte function in adolescent idiopathic scoliosis

Effects of the Schroth Method for Trunk Muscles’ Static Endurance and Spine Mobility in Girls With Idiopathic Scoliosis

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