Hysterectomy in the United States, 1988-1990

Wilcox, Lynne S.; Koonin, Lisa M.; Pokras, Robert; Strauss, Lilo T.; Xia, Zhisen; Peterson, Herbert B.

doi:10.1097/00006250-199404000-00011

Cited by 623 publications

(322 citation statements)

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“…An increase with age in the prevalence of fibroids during the reproductive years has been demonstrated by several epidemiologic studies (Marshall et al 1997;Ross et al 1986;Velebil et al 1995;Wilcox et al 1994). Studies that define cases by pathologic diagnosis, thus restricting cases to those having surgery (Ross et al 1986), have shown a rapid increase in fibroid diagnoses among women in their forties.…”

Section: Agementioning

confidence: 98%

“…The clinical effects of these tumors are related to their local mass effect, resulting in pressure upon adjacent organs, excessive uterine bleeding, or problems related to pregnancy, including infertility and repetitive pregnancy loss (Haney 2000). As a consequence of these local pressure effects and bleeding, uterine fibroids rank as the major reason for hysterectomy in the United States, accounting for approximately one-third of all hysterectomies (Wilcox et al 1994), or about 200,000 hysterectomies per year (Gambone et al 1990). …”

mentioning

confidence: 99%

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Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

494

392

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Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor-β 3, basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

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Section: Agementioning

confidence: 98%

mentioning

confidence: 99%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

494

392

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“…5,6 Because of the benign nature of the disease, supracervical or subtotal hysterectomy through a laparoscopic or open approach has been introduced. The supracervical hysterectomy removes only the uterus and leaves the cervix with the intention of preserving sexual, urinary, and bowel function.…”

Section: Introductionmentioning

confidence: 99%

Supracervical Robotic-Assisted Laparoscopic Sacrocolpopexy for Pelvic Organ Prolapse

Benson¹,

Kramer²,

Wayment³

et al. 2010

JSLS

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“…1,2 It is estimated that 20 -30% of women over the age of 30 will develop a leiomyoma. 1,3 Approximately half of the cases exhibit cytogenetic abnormalities. The most frequent genetic alterations are translocations involving the 12q15 region and deletions within the large arm of chromosome 7.…”

mentioning

confidence: 99%

Expression of N‐terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas

Moon

Zeng

Premdas

et al. 2002

Intl Journal of Cancer

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Genetic analyses and mRNA expression studies have implicated CUTL1 as a candidate tumor-suppressor gene in uterine leiomyomas and breast cancers. However, modulation of CDP/Cux, the protein encoded by CUTL1, does not agree with this notion. The activity of CDP/Cux, which is the DNA binding subunit of HiNF-D, was upregulated as normal cells progressed into S phase and constitutively elevated in several tumor cell lines. Activation of CDP/Cux at the G 1 /S transition involved the proteolytic processing of the protein to generate a shorter isoform. Uterine leiomyomas represent a unique reagent for molecular analysis because they are resected as homogenous tumor tissue together with the adjacent normal myometrium and they are often very large. In the present study, proteins were isolated from 16 pairs of matched tumors and adjacent myometrium and analyzed by Western blot and electrophoretic mobility shift assays. Strikingly, in 11/16 tumors, the steady-state level of small CDP/ Cux isoforms was increased compared to normal control tissue. Where tested, a corresponding increase in CDP/Cux stable DNA binding activity was observed. DNA sequencing analysis of CUTL1 cDNAs from 6 leiomyomas, including 4 with LOH of CUTL1, did not reveal any gross rearrangement or point mutations. Altogether these findings suggest that CUTL1 is probably not the tumor suppressor on 7q22. Moreover, the frequent increase in smaller CDP/Cux isoforms indicates that molecular events associated with the truncation of CDP/Cux proteins may be selected in uterine leiomyomas.

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Hysterectomy in the United States, 1988-1990

Cited by 623 publications

References 0 publications

Etiology and pathogenesis of uterine leiomyomas: a review.

Etiology and pathogenesis of uterine leiomyomas: a review.

Supracervical Robotic-Assisted Laparoscopic Sacrocolpopexy for Pelvic Organ Prolapse

Expression of N‐terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas

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