2009
DOI: 10.1016/j.molcel.2009.09.006
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Abstract: Summary Previous studies have suggested that the HIF transcription factors can both activate and inhibit gene expression. Here we show that HIF1 regulates the expression of mir-210 in a variety of tumor types through a hypoxia responsive element. Expression analysis in primary head & neck tumor samples indicates that mir-210 may serve as an in vivo marker for tumor hypoxia. By Argonaute protein immunoprecipitation, we identified 50 potential mir-210 targets and validated randomly selected ones. The majority of… Show more

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Cited by 539 publications
(569 citation statements)
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“…Based on these results, miR‐210 may play a role in the development of PQ‐induced pulmonary fibrosis. A direct regulatory role of HIF‐1α in the transcription of miR‐210 has recently been reported 20, 30, 31. The silencing of HIF‐1α expression also reduced miR‐210 expression.…”
Section: Discussionmentioning
confidence: 95%
“…Based on these results, miR‐210 may play a role in the development of PQ‐induced pulmonary fibrosis. A direct regulatory role of HIF‐1α in the transcription of miR‐210 has recently been reported 20, 30, 31. The silencing of HIF‐1α expression also reduced miR‐210 expression.…”
Section: Discussionmentioning
confidence: 95%
“…Silencing of miR-155 in lipopolysaccharide-treated mice results in de-repression of C/EBPb and downregulates granulocyte colony-stimulating factor expression (Worm et al, 2009). Upregulation of miR-210 regulates the hypoxic response of tumor cells and tumor growth (Huang et al, 2009). In a cellautonomous effect, MDS cells were found to grow more robustly under hypoxia conditions (Thompson et al, 2007).…”
Section: Discussionmentioning
confidence: 99%
“…Circulating miR-210 levels have been shown to correlate with trastuzumab sensitivity, tumor progression, and lymph node metastasis, suggesting that miR-210 can be used to predict and monitor the response of HER2þ breast cancer to trastuzumab (40). miR-210 is inducible by hypoxia, its targeting genes are mainly related to hypoxia and contribute to tumor initiation (41). In the miRTarBase (36), there are 69 genes that have been validated experimentally at least by 2 methods, including HIF1A and HIF3A (Supplementary Table S7).…”
Section: Er-bbb Casementioning
confidence: 99%