Hypovitaminosis D is associated with sleep disorders in workers on alternating shifts with cardiovascular risk factors

Abstract

Shift work has serious health impacts due to desynchronization of the circadian rhythm; consequently, the workers have increased sleep disturbances. Another impact is working hours, which can contribute to decreased sun exposure and lead to the development of hypovitaminosis D. Vitamin D has been implicated in extraskeletal functions in many physiological mechanisms, including sleep. Therefore, we aimed to verify the association between sleep parameters and hypovitaminosis D in shift workers with cardiovascular risk. We conducted a cross-sectional study of 82 male rotating shift workers (24-57 years old) with at least one cardiovascular risk factor (such as hyperglycemia, dyslipidemia, abdominal obesity, physical inactivity, hypertension, and smoking). Polysomnography was used to evaluate sleep parameters, while vitamin D levels were measured using a chemiluminescence method. Logistic regression was used to model the association between hypovitaminosis D and sleep parameters after adjustment for relevant covariates. Hypovitaminosis D (< 20 ng/mL) was seen in 30.5% of the workers. Shift workers with hypovitaminosis D had lower sleep efficiency, increased microarousal index, and lower arterial oxygen saturation after adjusting for seasonality, age, and body fat. Therefore, we suggest that hypovitaminosis D is associated with greater sleep disturbances in rotating shift workers with cardiovascular risk factors.

The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults

“…As demonstrated by Gao et al (2018), in a systematic review and meta-analysis of 9397 participants, individuals with vitamin D deficiency had a significantly increased chance for sleep disturbances [OR: 1.50; (95% CI: 1.31–1.72)], poor sleep quality OR: 1.59; [(95% CI: 1.23–2.05)], short sleep duration OR: 1.74; (95% CI: 1.30–2.32)], and excessive sleepiness [OR: 1.36; (95% CI: 1.12–1.65)] 2 . These results are supported by other studies conducted in different populations 5 , 18 , 24 , 25 , 30 . This evidence comes from different methods of sleep assessment, such as objective measurement 31 , self-reporting 32 , and systematic and meta-analytic analyses 2 , 33 – 35 .…”

Determinants of sleep quality in adults during the COVID-19 pandemic: COVID-Inconfidentes, a population-based study

“…These results are corroborated by intervention studies, but remain controversial (Huang et al 2013; Majid et al 2018). These results were found in a previous study with mining workers in the same region as this study; when evaluating sleep using the gold standard method, polysomnography, the workers with hypovitaminosis D had lower sleep efficiency, an increased microarousal index, and lower arterial oxygen saturation after adjusting for seasonality, age, and body fat (Menezes-Júnior et al 2021). These workers had routines similar to confinement during the COVID-19 pandemic, since they were off-highway truck drivers and spent most of their time in machines inaccessible to sunlight (Menezes Júnior et al 2021).…”

Determinants of Sleep Quality in Adults During the COVID-19 Pandemic: COVID-Inconfidentes, A Population-Based Study

“…This suggests a possible role for vitamin D de ciency in sleep disturbances [19]. These results were found in a previous study with mining workers in the same region as this study;when evaluating sleep using the gold standard method, polysomnography, the workers with hypovitaminosis D had more sleep disturbances [20]. These workers had routines similar to con nement during the COVID-19 pandemic, since they were off-highway truck drivers and spent most of their time in machines inaccessible to sunlight [21].…”