Hypovitaminosis D in Medical Inpatients

Thomas, Melissa K.; Lloyd‐Jones, Donald M.; Thadhani, Ravi; Shaw, Albert C.; Deraska, D J; Kitch, Barrett T.; Vamvakas, Eleftherios C.; Dick, Ian M.; Prince, Richard; Finkelstein, Joel S.

doi:10.1056/nejm199803193381201

Cited by 1,279 publications

(772 citation statements)

References 31 publications

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“…Although the sample is highly selected, the results emphasize that the problem of vitamin D deficiency is a worldwide problem in both hemispheres: in the South as previously reported in Australia, New Zeland and Argentina (Plantalech et al, 1997;Inderjeeth et al, 2000;Need et al, 2000) and in the North (US and Europe populations), where it has been extensively studied (Ooms et al, 1995;Thomas et al, 1998;Chapuy et al, 1996;van der Wielen et al, 1995;Le Boff et al, 1999).…”

Section: Discussionsupporting

confidence: 53%

“…This 'cut-off' value is similar to that proposed by Haden et al (1999): 25 ng/ml, Melin et al (1999): 30 ng/ml and Chapuy et al (1997): 31 ng/ml, and is similar to the cutoff level associated with an increase in bone markers (Need et al, 2002). However, other authors have proposed lower and higher levels as cutoff values: 12-16 ng/ ml (Ooms et al, 1995;Gloth et al, 1995;Thomas et al, 1998) and 44 ng/ml, respectively . This last value is very similar to the level proposed as being desirable to diminish fracture risk (Chapuy et al, 1992;Mc Kenna & Freaney, 1998).…”

Section: Discussionmentioning

confidence: 99%

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High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

et al. 2004

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Objective: To evaluate the nutritional status of vitamin D in urban populations of healthy elderly people living at home, in different regions of Argentina. Design: Cross-sectional study. Subjects: In total, 386 ambulatory subjects over 65 y of age from seven cities (between latitude 261S and 551S) were asked to participate between the end of winter and the beginning of spring. Of these, 369 accepted, 30 were excluded because of medical history or abnormal biochemical determinations. Finally, 339 subjects (226 women and 113 men) (X7s.d.) (71.37 5.2 y) were included. Results: Serum 25OHD levels were lowest in the South (latitude range: 411S-551S): 14.275.6 ng/ml (Po0.0001vs North and Mid regions); highest in the North (261S-271S): 20.777.4 ng/ml (Po0.03 vs Mid, Po0.0001vs South); and intermediate in the Mid region (331S-341S) 17.978.2 ng/ml. Serum mid-molecule PTH (mmPTH) and 25OHD were inversely related: (r ¼ À0.24, Po0.001). A cutoff level of 25OHD at which serum mmPTH levels began to increase was established at 27 ng/ml. A high prevalence (87-52%) of subjects with 25OHD levels in the deficiency-insufficiency range (25OHD levels o20 ng/ml) was detected. Conclusion: This study shows that vitamin D deficiency/insufficiency in the elderly is a worldwide problem. Correction of this deficit would have a positive impact on bone health of elderly people. Sponsorship: Asociació n Argentina de Osteología y Metabolismo Mineral (AAOMM).

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

et al. 2004

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“…We de®ned severe hypovitaminosis D as S-25(OH)D below 20 nmolal and moderate hypovitaminosis D as S-25(OH)D between 20 and 37.5 nmolal (Thomas et al, 1998). The de®nition of hypovitaminosis D was determined from published data demonstrating that serum parathyroid hormone concentration is inducing an increase in patients who have serum 25(OH)D concentrations 37.5 nmolal (Thomas et al, 1998).…”

Section: Hypovitaminosis Dmentioning

confidence: 99%

“…The de®nition of hypovitaminosis D was determined from published data demonstrating that serum parathyroid hormone concentration is inducing an increase in patients who have serum 25(OH)D concentrations 37.5 nmolal (Thomas et al, 1998).…”

Section: Hypovitaminosis Dmentioning

confidence: 99%

“…Currently vitamin D de®ciency occurs in elderly people in Europe (Heikinheimo et al, 1996;Lips et al, 1996) and it may be an important risk factor for osteoporotic hip fractures (Lips et al, 1987), as implied by the fact that supplementation with vitamin D and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women (Chapuy et al, 1992;Dawson-Hughes et al, 1997). Many studies have shown a signi®cant correlation between the dietary vitamin D intake and the serum 25-hydroxyvitamin D [S-25(OH)D] concentration in the elderly (Lips et al, 1987;Krall et al, 1989;Salamone et al, 1993;Thomas et al, 1998). Vitamin D from the diet is clearly important in the northern countries like Finland (Lamberg-Allardt, 1984).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D intake is low and hypovitaminosis D common in healthy 9− to 15-year-old Finnish girls

Lehtonen-Veromaa

Möttönen

Irjala³

et al. 1999

Eur J Clin Nutr

187

130

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Objectives: To study the prevalence of hypovitaminosis D, the effect of vitamin D supplementation on serum 25-hydroxyvitamin D [S-25(OH)D], and the intakes of vitamin D and calcium in Finnish 9-to 15-year-old athletic and nonathletic girls. Design: 1-year follow-up study (February 1997-March 1998 with three months of vitamin D supplementation (10 mgad) from October to January. Setting: Turku University Central Hospital, Finland. Subjects: 191 female volunteers aged 9 ± 15 y (131 athletes and 60 controls). Methods: Vitamin D and calcium intakes were estimated by a four-day food recording and a semi-quantitative food frequency questionnaire (FFQ). S-25(OH)D was followed by radioimmunoassay (RIA). Results: At baseline the mean S-25(OH)D concentration was 33.9 nmolal among all girls. In winter severe hypovitaminosis D (S-25(OH)D`20 nmolal) occurred in 13.4% of the participants and in 67.7% S-25(OH)D was below 37.5 nmolal. By the next summer the mean S-25(OH)D concentration was 62.9 nmolal and in 1.6% of the subjects it was below 37.5 nmolal. The prevalence of severe hypovitaminosis D was not signi®cantly reduced by three months of vitamin D (10 mgad) supplementation. At baseline, the mean intake of vitamin D was 2.9 mgad by food recording and 4.3 mgad by FFQ. The mean calcium intake was 1256 mgad and 1580 mgad, respectively. The intakes of vitamin D and calcium remained unchanged during the follow-up period. The athletes consumed more calcium than nonathletic controls, whereas the intake of vitamin D was quite similar among both groups. The vitamin D intake by FFQ correlated with the S-25(OH)D concentration in wintertime (r 0.28, P`0.01). Conclusion: Hypovitaminosis D is fairly common in growing Finnish girls in the wintertime, and three months of vitamin D supplementation with 10 mgad was insuf®cient in preventing hypovitaminosis D. The daily dietary vitamin D intake was insuf®cient (`5 mgad) in the majority of participants, while the calcium intake was usually suf®cient.

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Effect of Cholecalciferol Plus Calcium on Falling in Ambulatory Older Men and Women: A 3-Year Randomized Controlled Trial

Bischoff‐Ferrari¹

2006

Archives of Internal Medicine

132

110

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Background: A recent meta-analysis found that cholecalciferol (vitamin D) should reduce falls by more than 20%. However, little is known about whether supplemental cholecalciferol plus calcium citrate malate will lower the long-term risk of falling in men, active older individuals, and older individuals with higher 25hydroxyvitamin D levels. Methods:We studied the effect of 3-year supplementation with cholecalciferol-calcium on the risk of falling at least once in 199 men and 246 women 65 years or older and living at home. Individuals received 700 IU of cholecalciferol plus 500 mg of calcium citrate malate per day or placebo in a randomized double-blind manner. Subjects were classified as less physically active if physical activity was below the median level. Low 25hydroxyvitamin D levels were classified as those below 32 ng/mL (Ͻ80 nmol/L).Results: In 3 years, 55% of women and 45% of men re-

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Hypovitaminosis D in Medical Inpatients

Abstract: Hypovitaminosis D is common in general medical inpatients, including those with vitamin D intakes exceeding the recommended daily allowance and those without apparent risk factors for vitamin D deficiency.

Cited by 1,279 publications

References 31 publications

High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

Vitamin D intake is low and hypovitaminosis D common in healthy 9− to 15-year-old Finnish girls

Effect of Cholecalciferol Plus Calcium on Falling in Ambulatory Older Men and Women: A 3-Year Randomized Controlled Trial

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