Hypouricaemic effects of yoghurt containing<i>Lactobacillus gasseri</i>PA-3 in patients with hyperuricaemia and/or gout: A randomised, double-blind, placebo-controlled study

Yamanaka, Hisashi; Taniguchi, Atsuo; Tsuboi, Hiroshi; Kano, Hiroshi; Asami, Yukio

doi:10.1080/14397595.2018.1442183

Cited by 49 publications

(36 citation statements)

References 11 publications

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“…At current, only a small RCT has evaluated the effect of probiotics in patients affected with gout ( Table 1). This study showed a decrease in serum uric acid level in a subgroup of patients taking L. gasseri PA-3 over a period of 8 weeks (14). A reduction of uric acid has been demonstrated in a cohort of patients with hyperuricemia receiving two doses of L. gasseri PA-3 compared to placebo (15).…”

Section: Gout and Hyperuricemiamentioning

confidence: 59%

Benefits of Probiotics in Rheumatic Diseases

Oliviero

Spinella

2020

Front. Nutr.

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Rheumatic diseases are chronic conditions which affect a large proportion of the population worldwide (1). Among them, inflammatory chronic diseases including rheumatoid arthritis (RA), spondyloarthritis (SpA), crystal-induced arthritis (CIA), and connective tissue autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), are the most common. Chronic inflammation has been recognized to play a role also in osteoarthritis (OA), classically considered a non-inflammatory form of arthritis. Although different risk factors influence their onset and development, these heterogeneous conditions share common clinical outcome including joint pain, disability, and comorbidities (2). Over the last years increasing attention have been paid to the role of diet in the pathogenesis and progression of rheumatic diseases. It has been observed that healthy dietary habits and the consumption of foods rich in bioactive compounds, omega-3 fatty acids, and antioxidants are associated with a lower risk to develop these diseases and a less severe clinical outcome (3). In particular, an important link between gut microbiota and patients' clinical features highlighted the possibility to modulate disease progression and presentation through microbiota manipulation. In this setting, an emerging role might be attributed to probiotics, live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (4). The most commonly used are Lactobacilli (L.), Bifidobacteria (B.), and Streptococci (S.), either as single species or in mixed culture. Their health effects are largely recognized and supported by randomized controlled clinical trials (RCTs) and meta-analyses conducted on infectious diseases, antibiotic-associated diarrhea, irritable bowel syndrome, abdominal pain, and colitis (5, 6).

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Section: Gout and Hyperuricemiamentioning

confidence: 59%

Benefits of Probiotics in Rheumatic Diseases

Oliviero

Spinella

2020

Front. Nutr.

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“…The Lactobacillus DM9218 strain also acts on the purine nucleosides (inosine and guanosine) [ 55 , 56 ]. L. gasseri PA3 has demonstrated an ability to reduce purine in foods and beverages [ 57 , 58 , 61 ]. Purines are essential to viral RNA synthesis.…”

Section: Probiotics and Immunitymentioning

confidence: 99%

“…In the study, purine biosynthesis enzyme IMPDH2, which can be reduced by L. gasseri , could interact with the viral protein nsp14. L. gasseri PA-3 reduces the absorption of the main purines contained in food, and this property has been explored as adjuvant therapy in gout and hyperuricemia [ 61 ].…”

Section: Probiotics and Immunitymentioning

confidence: 99%

“…Thus, this study highlights that one of the promising nutritional strategies to be included for SARS-COV-2 infection is the ingestion of probiotics, especially L. gasseri , which can have beneficial effects on the host’s health, activating the immune response in cases of infection. Besides, studies demonstrated that L. gasseri PA-3 promoted the absorption and incorporation of inosine and compounds related to purine metabolism in vitro and reduced intestinal purine absorption in clinical studies [ 52 , 53 , 57 , 58 , 61 ].…”

Section: The Role Of Low-purine Dietsmentioning

confidence: 99%

“…Studies also show the association between high serum urates and the severity of HIV infection [ 59 ], which can help understand how the consumption of purine-rich foods could influence worsening clinical conditions in viral infections, such as those caused by a coronavirus. Thus, curiosity and interest in nutritional therapies to promote the reduction of purine intake have increased, whether using probiotics [ 33 , 52 , 53 , 57 , 58 ] or by dietary restriction advice on source foods [ 60 ], and consequently control of serum uric acid concentrations [ 61 ]. This behavior can positively influence the health of individuals with viral infections.…”

Section: Introductionmentioning

confidence: 99%

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Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

et al. 2020

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Infection caused by the SARS-CoV-2 coronavirus worldwide has led the World Health Organization to declare a COVID-19 pandemic. Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. In this context, alternatives related to nutritional therapy might help to control the infection. This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus gasseri and low-purine diets, particularly in individuals with hyperuricemia, as adjuvant nutritional therapies to improve the immune system and weaken viral replication, assisting in the treatment of COVID-19. These might be promising alternatives, in addition to many others that involve adequate intake of vitamins, minerals and bioactive compounds from food.

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