Hypothesis: nucleoid-associated proteins segregate with a parental DNA strand to generate coherent phenotypic diversity

Konto‐Ghiorghi, Yoan; Norris, Victor

doi:10.1007/s12064-020-00323-5

Cited by 4 publications

(1 citation statement)

References 90 publications

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“…It is worth noting here that certain mRNAs are located next to the genes that encode them (Llopis et al, 2010) and that, in eukaryotes, the same nucleus can contain both an active and an inactive nucleolus (Slodzian et al, 1992). In the strand segregation hypothesis, we proposed that, following DNA replication, each parental strand plus hyperstructures physically associated with it confers a particular phenotype on the daughter cell into which it is segregated (Rocha et al, 2003;Konto-Ghiorghi and Norris, 2020). Since these hyperstructures could be of the equilibrium or the non-equilibrium type, one daughter could receive a parental DNA strand plus equilibrium hyperstructures that steer it toward a slow growth phenotype whilst the other daughter could receive the other parental DNA strand plus non-equilibrium hyperstructures that steer it toward a fast growth phenotype (Norris et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Generation of Bacterial Diversity by Segregation of DNA Strands

Norris

Ripoll

2021

Front. Microbiol.

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The generation in a bacterial population of a diversity that is coherent with present and future environments is a fundamental problem. Here, we use modeling to investigate growth rate diversity. We show that the combination of (1) association of extended assemblies of macromolecules with the DNA strands and (2) the segregation of DNA strands during cell division allows cells to generate different patterns of growth rate diversity with little effect on the overall growth rate of the population and thereby constitutes an example of “order for free” on which evolution can act.

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Section: Introductionmentioning

confidence: 99%

Generation of Bacterial Diversity by Segregation of DNA Strands

Norris

Ripoll

2021

Front. Microbiol.

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Self-assembled nucleoid proteins scaffold bacterial DNA

Zhao¹

2021

Biophysical Journal

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The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in bacteria

Norris

Kayser

Muskhelishvili

et al. 2022

FEMS Microbiology Reviews

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How to adapt to a changing environment is a fundamental, recurrent problem confronting cells. One solution is for cells to organise their constituents into a limited number of spatially extended, functionally relevant, macromolecular assemblies or hyperstructures, and then to segregate these hyperstructures asymmetrically into daughter cells. This asymmetric segregation becomes a particularly powerful way of generating a coherent phenotypic diversity when the segregation of certain hyperstructures is with only one of the parental DNA strands and when this pattern of segregation continues over successive generations. Candidate hyperstructures for such asymmetric segregation in prokaryotes include those containing the Nucleoid-Associated Proteins (NAPs) and the topoisomerases. Another solution to the problem of creating a coherent phenotypic diversity is by creating a growth-environment-dependent gradient of supercoiling generated along the replication origin-to-terminus axis of the bacterial chromosome. This gradient is modulated by transcription, NAPs and topoisomerases. Here, we focus primarily on two topoisomerases, TopoIV and DNA gyrase in Escherichia coli, on three of its NAPs (H-NS, HU and IHF), and on the single-stranded binding protein, SSB. We propose that the combination of supercoiling-gradient-dependent and strand-segregation-dependent topoisomerase activities result in significant differences in the supercoiling of daughter chromosomes and hence in the phenotypes of daughter cells.

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Hypothesis: nucleoid-associated proteins segregate with a parental DNA strand to generate coherent phenotypic diversity

Cited by 4 publications

References 90 publications

Generation of Bacterial Diversity by Segregation of DNA Strands

Generation of Bacterial Diversity by Segregation of DNA Strands

Self-assembled nucleoid proteins scaffold bacterial DNA

The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in bacteria

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