Hypothesis

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions

“… 51 In the acute phase of NAION, both cytotoxic and vasogenic edema caused damage in the ON and the surrounding retina. 52 In the present study, the BRB was examined by performing ZO-1 staining at day 3 after AION, showing that E212 maintained the RPE polarity and tight junction after an ischemic insult. This result indicated that E212 can potentially protect the integrity of the vessel barrier after an ON infarct.…”

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions

“… 51 In the acute phase of NAION, both cytotoxic and vasogenic edema caused damage in the ON and the surrounding retina. 52 In the present study, the BRB was examined by performing ZO-1 staining at day 3 after AION, showing that E212 maintained the RPE polarity and tight junction after an ischemic insult. This result indicated that E212 can potentially protect the integrity of the vessel barrier after an ON infarct.…”

Ischemic Optic Neuropathy in Cardiac Surgery

“…Estrogen improves vascular function and decreases atherosclerosis; however, female sex had decreased odds of ION in our study even when controlling for vascular disease and carotid artery stenosis in the multivariable regression leaving the mechanism for this decrease unclear. 38,39 The reason why ION risk in this study differed between uncomplicated diabetes mellitus type 2 and diabetic retinopathy is not known and will require further study.…”

Evaluation of ocular pulse amplitude in non-arteritic anterior ischaemic optic neuropathy

“…Hayreh stated that NAION is a hypotensive disorder, arising from transient noctural non-perfusion or hypoperfusion of the blood vessels in the optic nerve head, and is not caused by occlusion of the SPCAs as has been frequently previously claimed [29]. The lack of consistent choroidal filling delay demonstrated in fluorescein angiography studies of NAION has suggested that the impaired perfusion originates in the paraoptic tributaries of the SPCAs, which are distal to the split from the choroidal branches [30]. This, therefore, could explain the lack of any change in the OPA results in the current study.…”

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions

“… 51 In the acute phase of NAION, both cytotoxic and vasogenic edema caused damage in the ON and the surrounding retina. 52 In the present study, the BRB was examined by performing ZO-1 staining at day 3 after AION, showing that E212 maintained the RPE polarity and tight junction after an ischemic insult. This result indicated that E212 can potentially protect the integrity of the vessel barrier after an ON infarct.…”

Ischemic Optic Neuropathy in Cardiac Surgery

“…Estrogen improves vascular function and decreases atherosclerosis; however, female sex had decreased odds of ION in our study even when controlling for vascular disease and carotid artery stenosis in the multivariable regression leaving the mechanism for this decrease unclear. 38,39 The reason why ION risk in this study differed between uncomplicated diabetes mellitus type 2 and diabetic retinopathy is not known and will require further study.…”

Evaluation of ocular pulse amplitude in non-arteritic anterior ischaemic optic neuropathy

“…Hayreh stated that NAION is a hypotensive disorder, arising from transient noctural non-perfusion or hypoperfusion of the blood vessels in the optic nerve head, and is not caused by occlusion of the SPCAs as has been frequently previously claimed [29]. The lack of consistent choroidal filling delay demonstrated in fluorescein angiography studies of NAION has suggested that the impaired perfusion originates in the paraoptic tributaries of the SPCAs, which are distal to the split from the choroidal branches [30]. This, therefore, could explain the lack of any change in the OPA results in the current study.…”

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions

“… 51 In the acute phase of NAION, both cytotoxic and vasogenic edema caused damage in the ON and the surrounding retina. 52 In the present study, the BRB was examined by performing ZO-1 staining at day 3 after AION, showing that E212 maintained the RPE polarity and tight junction after an ischemic insult. This result indicated that E212 can potentially protect the integrity of the vessel barrier after an ON infarct.…”

Ischemic Optic Neuropathy in Cardiac Surgery

“…Estrogen improves vascular function and decreases atherosclerosis; however, female sex had decreased odds of ION in our study even when controlling for vascular disease and carotid artery stenosis in the multivariable regression leaving the mechanism for this decrease unclear. 38,39 The reason why ION risk in this study differed between uncomplicated diabetes mellitus type 2 and diabetic retinopathy is not known and will require further study.…”

Evaluation of ocular pulse amplitude in non-arteritic anterior ischaemic optic neuropathy

“…Hayreh stated that NAION is a hypotensive disorder, arising from transient noctural non-perfusion or hypoperfusion of the blood vessels in the optic nerve head, and is not caused by occlusion of the SPCAs as has been frequently previously claimed [29]. The lack of consistent choroidal filling delay demonstrated in fluorescein angiography studies of NAION has suggested that the impaired perfusion originates in the paraoptic tributaries of the SPCAs, which are distal to the split from the choroidal branches [30]. This, therefore, could explain the lack of any change in the OPA results in the current study.…”