Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia

Abstract

Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia (Review)

Oral corticosteroids for asthma exacerbations might be associated with adrenal suppression: Are physicians aware of that?

“…10 It has been described that any subject who has taken 20 mg of prednisone for 5 days or longer is at risk of HPA axis suppression. 11 As previously shown 12 and corroborated in our study, HPA axis dysfunction at baseline conditions may already be detected at the very first week after discontinuation of OCS treatment. After corticosteroid withdrawal, central recovery precedes the peripheral recovery but AS may take longer to cure.…”

“…12,[14][15][16] In asthma controller treatment, side effects due to ICS use may be triggered by many variables such as bioavailability related to dosage, delivery device, particle size and lung versus upper airway deposition. 18 Evidences of HPA dysfunction due to ICS have been reported in the literature in up to 40% 10,19-23 of cases and due to OCS in up to 80%.…”

Analysis of Induction Phase Glucocorticoid Use on Adrenal Suppression in Pediatric Patients With Acute Lymphoblastic Leukemia

“…The incidence of patients who have adrenal suppression LLA differs from chemotherapy protocols with other chemotherapy protocols. This is due to the dosage and type of glucocorticoids as well as the method and duration of cessation of glucocorticoids are different from one protocol chemotherapy to another (Gordijn et al 2012).…”

“…Each of these protocols used type, dose, duration of use, method of tapering and tapering off on different glucocorticoids (Gordijn et al 2012). Some protocols reported incidence of adrenal suppression at 83-100% after the discontinuation of glucocorticoids given day for 21 days (Einaudi et al 2008, Rix et al 2005.…”

Supresión del eje hipotálamo-hipófisis-suprarrenal después de la quimioterapia de inducción en niños con leucemia linfoide aguda

“…Vestergaard y colaboradores (23) encontraron asociación entre el subtipo de leucemia y la duración de la IS. En una revisión sistemática de la literatura de la colaboración Cochrane se menciona que los antifún-gicos pueden contribuir a la mayor duración de la supresión adrenal; ninguno de nuestros pacientes recibió dichos fármacos durante el tiempo del estudio (24).…”