2014
DOI: 10.18632/aging.100641 View full text |Buy / Rent full text
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Abstract: Glucose homeostasis and LeptinThe dogma that the pancreatic-beta-cell-secreted hormone insulin is an absolute prerequisite for survival has withstood for almost a century. Precisely, since the early 1920s when insulin was first discovered and shown to rescue the lethality and part of the metabolic aberrancies caused by insulin deficiency in humans [1]. However, recent results from different groups have called into question the notion that life without insulin is incompatible. In 2008, Unger and colleagues repo… Show more

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“…We know that disruption of leptin signaling and leptin resistance plays a critical role in obesity, a major risk factor for morbidity and mortality, and obesity-related disease such as impaired glucose metabolism, cancer, and the development of cardiovascular disease. Improvements in insulin sensitivity and modulation of the IIS pathway and the subsequent increase in lifespan are much better understood with pathways conserved from worms to humans [ 142 ]. The hypothesis that CR decreases oxidative damage and increases antioxidant enzyme levels was not supported here.…”
Section: Discussionmentioning
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“…We know that disruption of leptin signaling and leptin resistance plays a critical role in obesity, a major risk factor for morbidity and mortality, and obesity-related disease such as impaired glucose metabolism, cancer, and the development of cardiovascular disease. Improvements in insulin sensitivity and modulation of the IIS pathway and the subsequent increase in lifespan are much better understood with pathways conserved from worms to humans [ 142 ]. The hypothesis that CR decreases oxidative damage and increases antioxidant enzyme levels was not supported here.…”
Section: Discussionmentioning
“…We thus assessed whether these parameters could be linked to atrophy in lemurs and found that it is probably the main factor leading to pathologic hippocampal/ septal atrophy and the associated cognitive alterations in lemurs. Yet, reverse cause-effect relations are also possible [ 35 ].…”
Section: Discussionmentioning
“…The SLC2A2 level is increased in hyperglycemia and decreased in hyperinsulinemia [40]. Leptin receptor overlapping transcript (LEPROT) is involved in the expression of growth hormone and leptin receptors, which are associated with hyperglycemia [41]. Endothelial cell-specific molecule 1 (ESM1) is regulated by cytokines and could have a role in the endothelial dysfunction [42].…”
Section: Network Associated With Hyperglycemiamentioning