Glucose homeostasis and LeptinThe dogma that the pancreatic-beta-cell-secreted hormone insulin is an absolute prerequisite for survival has withstood for almost a century. Precisely, since the early 1920s when insulin was first discovered and shown to rescue the lethality and part of the metabolic aberrancies caused by insulin deficiency in humans . However, recent results from different groups have called into question the notion that life without insulin is incompatible. In 2008, Unger and colleagues rep…
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