1963
DOI: 10.1136/jcp.16.2.144
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Abstract: The patient looked older than his stated age. The skin and mucosae showed some pallor, and the former was very fine and soft. Changes attributable to rheumatoid arthritis affected the joints previously mentioned. His nails were beaked. There was slight bilateral ankle oedema. Suprapubic, axillary, and beard-area hair was Received for publication 17 September 1962 very sparse. The hair on the scalp was thin but evenly distributed. The external genitalia were normal in appearance. The tongue was reddened and … Show more

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Cited by 26 publications
(12 citation statements)
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“…3,4,6,8 There have also been occasional reports of melanomas originating unequivocally from the leptomeninges of the sellar region. [9][10][11][12] In the present patient we were unable to identify a primary site of origin of the melanoma despite detailed dermatological and radiological review. We acknowledge that there are reports of primary melanoma of the gastrointestinal system that might not be identified on CT scanning of the abdomen, 13 as well as documented regression of cutaneous malignant melanoma.…”
Section: Discussionmentioning
confidence: 56%
See 1 more Smart Citation
“…3,4,6,8 There have also been occasional reports of melanomas originating unequivocally from the leptomeninges of the sellar region. [9][10][11][12] In the present patient we were unable to identify a primary site of origin of the melanoma despite detailed dermatological and radiological review. We acknowledge that there are reports of primary melanoma of the gastrointestinal system that might not be identified on CT scanning of the abdomen, 13 as well as documented regression of cutaneous malignant melanoma.…”
Section: Discussionmentioning
confidence: 56%
“…To our knowledge there have been only 30 patients reported previ- ously. [4][5][6][7][8][9][10][11] The majority of these were autopsy findings in the context of disseminated spread; however, there are seven patients where clinical symptoms associated with the pituitary metastasis are described. 3,4,6,8 There have also been occasional reports of melanomas originating unequivocally from the leptomeninges of the sellar region.…”
Section: Discussionmentioning
confidence: 98%
“…A hypothetical third possibility is that primary sellar melanocytic tumors arise in adenohypophyseal cells. It was suggested that adenohypophyseal cells may produce melanin and these cells can be the source of the sellar melanocytic tumors [20]. Recent studies suggest that tumor cells have the potential for cells from the anterior pituitary to transform from one cell type to another [21].…”
Section: Discussionmentioning
confidence: 98%
“…Sellar melanocytic tumors are immunonegative for synaptophysin, a neuronal and neuroendocrine cell marker, for epithelial cell markers and for pituitary hormones. Of 12 cases of melanocytic tumors of the sella reported previously, immunopositivity for S-100 was reported in 6 cases [3,4,6,7,9,15], vimentin in 3 cases [1,7,15], and other markers such as epithelial membrane antigen (EMA) and Masson-Fontana positivity in various others [1,3,5,15,20]. The most useful marker was Hmb-45, which has high sensitivity and specificity and was positive in 8 cases [1,3,4,[6][7][8][9]15].…”
Section: Diagnostic Biomarkersmentioning
confidence: 96%
“…Primary sellar melanocytic tumors are exceedingly rare, and less than 10 cases have been reported in the literature [1][2][3][4][5][6][7][8]. They can cause progressive tumor syndrome, hypopituitarism, and mimic hormonally inactive pituitary macroadenoma both clinically and radiologically [9].…”
Section: Introductionmentioning
confidence: 99%