Hyponatremia in tuberculous meningitis: A systematic review and meta-analysis

Hieu, Truong Hong; Hashan, Mohammad Rashidul; Morsy, Sara; Tawfik, Gehad Mohamed; Cucè, Federica; Sharma, Akash; Quynh, Tran Thuy Huong; Faraj, Hazem Abdelkarem; Qarawi, Ahmad Taysir Atieh; Huy, Nguyen Tien

doi:10.1016/j.ijtb.2021.06.004

Cited by 4 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on the test results, treatment and nursing plans should be adjusted to reduce the occurrence of complications [ 22 ]. A previous study found that the prevalence of hyponatremia in patients with TBM was 52%, and the mortality rate was 29% [ 23 ], therefore hyponatremia requires clinical attention.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of tuberculous meningitis in older patients compared with younger and middle-aged patients: a retrospective analysis

Zhu,

He,

Tong

et al. 2023

BMC Infect Dis

View full text Add to dashboard Cite

Background Few studies have analyzed the clinical characteristics and adverse factors affecting prognosis in older patients with tuberculous meningitis (TBM). This study aimed to compare the clinical characteristics of TBM in older patients with those in younger and middle-aged patients. Methods This single-center retrospective study extracted data on the clinical features, cerebrospinal fluid changes, laboratory results, imaging features, and outcomes of patients with TBM from patient medical records and compared the findings in older patients (aged 60 years and older) with those of younger and middle-aged patients (aged 18–59 years). Results The study included 197 patients with TBM, comprising 21 older patients aged 60–76 years at onset, and 176 younger and middle-aged patients aged 18–59 years at onset. Fever was common in both older (81%) and younger and middle-aged patients (79%). Compared with younger and middle-aged patients, older patients were more likely to have changes in awareness levels (67% vs. 40%), peripheral nerve dysfunction (57% vs. 29%), changes in cognitive function (48% vs. 20%), and focal seizures (33% vs. 6%), and less likely to have headache (71% vs. 93%), neck stiffness on meningeal stimulation (38% vs. 62%), and vomiting (47% vs. 68%). The Medical Research Council staging on admission of older patients was stage II (52%) and stage III (38%), whereas most younger and middle-aged patients had stage I (33%) and stage II (55%) disease. Neurological function evaluated on the 28th day of hospitalization was more likely to show poor prognosis in older patients than in younger and middle-aged patients (76% vs. 25%). Older patients had significantly higher red blood cell counts and blood glucose levels, and significantly lower serum albumin and sodium levels than those in younger and middle-aged patients. The cerebrospinal fluid protein levels, nucleated cell counts, glucose levels, and chloride levels did not differ significantly by age. Conclusion In patients with TBM, older patients have more severe clinical manifestations, a higher incidence of hydrocephalus and cerebral infarction, and longer hospital stays than younger and middle-aged patients. Older patients thus require special clinical attention.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of tuberculous meningitis in older patients compared with younger and middle-aged patients: a retrospective analysis

Zhu,

He,

Tong

et al. 2023

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…La MT se puede presentar con un amplio rango de manifestaciones clínicas y complicaciones, como, por ejemplo, la hiponatremia que se asocia a un incremento de mortalidad y que puede ser causada principalmente por dos mecanismos: cerebro perdedor de sal (CSW) o el síndrome de secreción inadecuada de hormona antidiurética (SIADH) (3) . Una revisión sistemática de 42 estudios encontró una prevalencia de hiponatremia en pacientes con meningitis tuberculosa de 52% (4) .…”

Section: Introductionunclassified

Hiponatremia severa por meningitis tuberculosa: complicación frecuente pero olvidada

Hurtado-Alegre,

Carrasco-Lozano,

Milicic-Mori

et al. 2023

An Fac med

View full text Add to dashboard Cite

Se presenta el caso de un paciente varón de 55 años que ingresó por alteración del estado de conciencia por una hiponatremia severa secundaria a una meningitis tuberculosa. No hubo mejoría de la hiponatremia al tratamiento con solución salina hipertónica, por lo cual se planteó el diagnóstico de síndrome de secreción inapropiada de hormona antidiurética (SIADH) y se evidenció mejoría con la restricción hídrica. El interés del presente caso es reportar una complicación frecuente pero olvidada de la meningitis tuberculosa.

show abstract

Seizures and epilepsy associated with central nervous system tuberculosis

Ramos

Burneo

2023

Seizure: European Journal of Epilepsy

View full text Add to dashboard Cite

Hyponatremia in tuberculous meningitis: A systematic review and meta-analysis

Cited by 4 publications

References 52 publications

Clinical characteristics of tuberculous meningitis in older patients compared with younger and middle-aged patients: a retrospective analysis

Clinical characteristics of tuberculous meningitis in older patients compared with younger and middle-aged patients: a retrospective analysis

Hiponatremia severa por meningitis tuberculosa: complicación frecuente pero olvidada

Seizures and epilepsy associated with central nervous system tuberculosis

Contact Info

Product

Resources

About