Hyponatraemia Following Cisplatin Chemotherapy

Abstract

View related articles Citing articles: 6 View citing articles Correspondence and Short Communications Comments on published articles, short communications of a preliminary nature, case reports, tecknical notes and the like are accepted under this heading. The articles should be short and concise and contain a minumum offigures, tables and references.

Hyponatremia related to medical anticancer treatment

“…In some cases, it can be prevented by an appropriate treatment [40,50,62,69,73,78]. Other possibilities are to use analogs, such as carboplatin against hyponatremia induced by cisplatin, but the risk remains of inducing an excessive natriuresis [4], reducing the dosage as observed with melphalan [27] or the schedule of administration as tested with vinblastine [52].…”

“…The treatments used to correct hyponatremia are known to be active against SIADH: demeclocycline, for treatment or prevention of recurrence of SIADH, and fluid restriction, eventually associated with furosemide and hypertonic saline perfusion. These treatments have been used with success [4,40,49,54]. For example, Levin et al [40] gave demeclocycline at a dose of 300 mg every 6 h for 3 days to a woman treated with cisplatin alone for a malignant thymoma presenting with hyponatremia in the previous course.…”

“…It presents with central nervous system symptoms as described with vinca alkaloids [4,16,36,40,43,49,54] or orthostatic dizziness [31, 36,78]. Its reversibility is less frequent than with vinca alkaloids, essentially in cases of renal salt wasting.…”

Diagnosis and management of hyponatremia in cancer patients

“…The chemotherapeutic agents vincristine, vinblastine, cyclophosphamide, cisplatin, and [33,39,47], and cisplatin diminishes renal function [9,14,18,32]. Nausea induced by chemotherapy, as well as radiotherapy to the abdominal area, promotes the release of AVP; vomiting is also a potent stimulus for AVP release and leads to gastrointestinal loss of sodium [16,27,41].…”

“…Nausea induced by chemotherapy, as well as radiotherapy to the abdominal area, promotes the release of AVP; vomiting is also a potent stimulus for AVP release and leads to gastrointestinal loss of sodium [16,27,41]. In addition to chemotherapy itself, the vigorous hydration administered to prevent cisplatin nephrotoxicity, hemorrhagic cystitis, or tumor lysis syndrome can produce or exacerbate hyponatremia [9,32,45]. Immunomodulators including interferon, interleukin-2, and levamisole, as well as monodonal antibodies, have also been shown to induce hyponatremia [6].…”