Hypolipidemic Effect ofGlycine tomentellaRoot Extract in Hamsters

Abstract

The influence of the aqueous crude extract of Glycine tomentella root (Leguminosae) on lipid metabolism was investigated in hyperlipidemic hamsters. It was found that the administration of the G. tomentella extract (GTE) leads to a decrease of high serum cholesterol and triglyceride levels induced by high-fat diet. The GTE also increased serum high-density lipoprotein (HDL) cholesterol and decreased serum low-density lipoprotein (LDL) cholesterol. The reduction of serum triglyceride levels was accompanied by a significant decrease in the hepatic triglyceride content, while the cholesterol content was not changed. The results indicate that GTE is definitely an anti-hyperlipidemic agent, at least, in animals.

Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice

“…Phytochemical analysis shows the presence of polyphenols in the AGT (Ko et al, 2004). The concentration of polyphenols in AGT was 35.4 mg/g (Ko et al, 2004).…”

“…The root of Glycine tomentella Hayata (Fabaceae) has long been used in the Knimen area of Taiwan as an anti-inflammatory agent for the treatment of rheumatic illness (Ko et al, 2004), gout, arthritis, and body aches (Chen, 1979;Ko et al, 2004), indicative of its anti-inflammatory activity. Recently, herbal tea of glycine radix (GR) has been developed for commercial purposes in Taiwan.…”

“…Recently, herbal tea of glycine radix (GR) has been developed for commercial purposes in Taiwan. GR has higher anti-oxidative and free radical scavenging effects in addition to inhibit the cyclooxygenase II (COX II) activity in vitro (Bonnie et al, 2005), inhibition of 12-and 15-lipooxygenase activities and protection of human and Tilapia low density lipoprotein oxidation (Chen et al, 2005) and hypolipidemic effects in the hamster (Ko et al, 2004). However, there is less study on the analgesic and anti-inflammatory activities of GR in vivo.…”

Composition of flavonoids and phenolic acids in Glycin tomentella Hayata cultivated in various soils

“…It has been used to help treat arthritis and rheumatism for a long time (Ko, Wu, & Lin, 2004). Recently the herb has also been exploited as a functional tea, steeped wine and related products for commercial purposes in Taiwan, due to its health benefits.…”

“…Recently the herb has also been exploited as a functional tea, steeped wine and related products for commercial purposes in Taiwan, due to its health benefits. It has been reported that the roots of G. tomentella Hayata has several biological activities, such as antioxidant (Chen & Pan, 2007;Chen, Shiao, & Pan, 2005), hypolipidaemic (Ko et al, 2004, Chen & Pan, 2007, analgesic (Lu et al, 2007), anti-inflammatory (Chen et al, 2005;Lu et al, 2007), and immunomodulatory (Chuang, Haugland, Pan, & Evensen, 2008).…”