2010
DOI: 10.1002/mnfr.200900251
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Abstract: Controversial data on the lipid-lowering effect of dietary pea proteins have been provided and the mechanisms behind this effect are not completely understood. The aim of the study was to evaluate a possible hypolipidemic activity of a pea protein isolate and to determine whether pea proteins could affect the hepatic lipid metabolism through regulation of genes involved in cholesterol and fatty acid homeostasis. Rats were fed Nath's hypercholesterolemic diets for 28 days, the protein sources being casein or a … Show more

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Cited by 47 publications
(48 citation statements)
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“…The alpha-1 globulin fraction include (α 1 -antitrypsin,α 1 -acid glycoprotein, α 1 -lipoprotein (Apolipoprotein A), α 1 -fetoprotein (AFP), transcortine, protein connecting thyroxine, glycoprotein) (Turgut, 2000;Mehmetoglu, 2002;SPEP). Pea proteins markedly reduces blood cholesterol and triglyceride levels in rats (Martins et al, 2004;Rigamonti et al, 2010;Sirtori et al, 2012). Dietary pea has a lowering effect on the blood lipid concentrations of rats (Spielmann et al, 2008).…”
Section: Discussionmentioning
confidence: 97%
“…The alpha-1 globulin fraction include (α 1 -antitrypsin,α 1 -acid glycoprotein, α 1 -lipoprotein (Apolipoprotein A), α 1 -fetoprotein (AFP), transcortine, protein connecting thyroxine, glycoprotein) (Turgut, 2000;Mehmetoglu, 2002;SPEP). Pea proteins markedly reduces blood cholesterol and triglyceride levels in rats (Martins et al, 2004;Rigamonti et al, 2010;Sirtori et al, 2012). Dietary pea has a lowering effect on the blood lipid concentrations of rats (Spielmann et al, 2008).…”
Section: Discussionmentioning
confidence: 97%
“…However pea protein additionally offers other potential health benefits, including the prevention of infection in the gastrointestinal tract [24], reducing circulating levels of lipids [25]and reducing hypertension [26,27]. Replacing animal derived proteins with pea protein also has economic and sustainability advantages, in aiding the reduction of global warming, eutrophication, acidification and land use [28].…”
Section: Introductionmentioning
confidence: 99%
“…Studies on fish peptides have demonstrated antihypertensive [2-5], antioxidant [6-9], and immunomodulating effects [10], as well as reparative properties in the intestine [11,12]. Hydrolyzed proteins from plant and fish have been demonstrated to alter the cholesterol and lipid metabolism in rodent studies, and to reduce plasma cholesterol and triglyceride levels [1,13-15]. In addition, we previously found a reduction in hepatic ∆5 and ∆6 desaturase mRNA expression in obese Zucker rats by a fish protein hydrolysate (FPH) diet [16].…”
Section: Introductionmentioning
confidence: 99%