Hypolipidemic and antioxidant activities of<i>Trichosanthes kirilowii</i>maxim seed oil and flavonoids in mice fed with a high‐fat diet

Hou, Zongkun; Zhu, Lingyu; Meng, Run; Wang, Bochu

doi:10.1111/jfbc.13272

Cited by 11 publications

(7 citation statements)

References 48 publications

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“…Both of our formulations have mild antioxidant effects ( Table 1 ) and can serve as a herbal exogenous source of antioxidants to protect from oxidative stress and resulting comorbidities. This finding is further supported by literature showing antioxidant activity and identification of antioxidant molecules in Citrus reticulata [ 46 ], Houttuynia cordata [ 47 ], Cassia obtusifolia [ 48 ], and Benincasa hispida [ 49 ] of formulation A and Acanthopanax gracilistylus [ 50 ], Dioscorea opposite [ 51 ], Momordica charantia [ 52 ], and Trichosanthis kirilowii [ 53 ] of formulation B.…”

Section: Discussionsupporting

confidence: 79%

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Antiobesity Activity of Two Polyherbal Formulations in High-Fat Diet-Induced Obese C57BL/6J Mice

Pandeya

Lamichhane

et al. 2022

BioMed Research International

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Obesity and overweight have posed a severe threat to humanity, needing urgent efforts for the development of safe and effective therapeutic interventions. In this research work, we have developed two polyherbal formulations A and B basically consisting of Helianthus tuberosus root powder (also called inulin of synanthrin) along with other herbs for the treatment of obesity. Evaluation of the antioxidant activity of both formulations using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2 ′ -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging assays showed good antioxidant potentials. Both formulations A and B showed good antiobesity activity on a diet-induced obesity (DIO) model of mice by effectively lowering the body weight of mice compared to the high-fat diet (HFD) control mice, mainly by reducing the food efficiency ratio (FER). Furthermore, both formulations ameliorated lipoprotein misbalances induced by obesity and thus decreased the atherogenic index. Treatment with both formulations significantly decreased the liver and epididymal white adipose tissue (WAT) weight. This was supported by the improvement in steatosis of the liver and reduced hypertrophy in WAT on histological examination. In addition, formulations A and B have been seen as effective in controlling fasting blood glucose levels probably by alleviating HFD-induced insulin resistance. All of these results collectively suggest that formulations A and B serve as potentially safe and effective herbal interventions to control obesity and its comorbidities.

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Section: Discussionsupporting

confidence: 79%

“…Momordica charantia, also known as bitter gourd, has well-known health benefits including antidiabetic, anti-inflammatory, antihypertensive, and hypoglycemic effects [ 73 , 74 ]. Trichosanthis kirilowii was also found to have hypoglycemic and hypolipidemic activities [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Antiobesity Activity of Two Polyherbal Formulations in High-Fat Diet-Induced Obese C57BL/6J Mice

Pandeya

Lamichhane

et al. 2022

BioMed Research International

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“…Similarly, Pinellia ternate is reported to have anxiolytic, anti-inflammatory [ 68 ], anti-arrhythmic, lowering blood pressure, and anti-obesity effects [ 69 ]. Trichosanthes kirilowii is known for its anti-inflammatory and antioxidant activities [ 70 , 71 ]. Glycyrrhiza uralensis and Ligusticum sinense are known to have anti-fatigue and anti-bacterial activities, respectively [ 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

Designing combinational herbal drugs based on target space analysis

Woyessa,

Bultum,

Lee

2024

BMC Complement Med Ther

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Background Traditional oriental medicines (TOMs) are a medical practice that follows different philosophies to pharmaceutical drugs and they have been in use for many years in different parts of the world. In this study, by integrating TOM formula and pharmaceutical drugs, we performed target space analysis between TOM formula target space and small-molecule drug target space. To do so, we manually curated 46 TOM formulas that are known to treat Anxiety, Diabetes mellitus, Epilepsy, Hypertension, Obesity, and Schizophrenia. Then, we employed Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties such as human ether-a-go-go related gene (hERG) inhibition, Carcinogenicity, and AMES toxicity to filter out potentially toxic herbal ingredients. The target space analysis was performed between TOM formula and small-molecule drugs: (i) both are known to treat the same disease, and (ii) each known to treat different diseases. Statistical significance of the overlapped target space between the TOM formula and small-molecule drugs was measured using support value. Support value distribution from randomly selected target space was calculated to validate the result. Furthermore, the Si-Wu-Tang (SWT) formula and published literature were also used to evaluate our results. Result This study tried to provide scientific evidence about the effectiveness of the TOM formula to treat the main indication with side effects that could come from the use of small-molecule drugs. The target space analysis between TOM formula and small-molecule drugs in which both are known to treat the same disease shows that many targets overlapped between the two medications with a support value of 0.84 and weighted average support of 0.72 for a TOM formula known to treat Epilepsy. Furthermore, support value distribution from randomly selected target spaces in this analysis showed that the number of overlapped targets is much higher between TOM formula and small-molecule drugs that are known to treat the same disease than in randomly selected target spaces. Moreover, scientific literature was also used to evaluate the medicinal efficacy of individual herbs. Conclusion This study provides an evidence to the effectiveness of a TOM formula to treat the main indication as well as side effects associated with the use of pharmaceutical drugs, as demonstrated through target space analysis.

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“…Pharmacological tests have also demonstrated the pharmacological activities of T. kirilowii in anti-tumor, antioxidation, neuroprotection, lowering blood lipids, and reducing kidney damage (Lv et al, 2018;Lu et al, 2019;Hou et al, 2020;Ku et al, 2020). However, cultivated T. kirilowii plants are constantly attacked by a variety of plant diseases, posing a serious threat to the T. kirilowii industry (Li and Zhang, 2007;Zhang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…In clinical treatment, T. kirilowii plays an important role in the treatment of thoracic obstruction, angina pectoris, heart failure, myocardial infarction, pulmonary heart disease, and cerebral ischemic diseases ( Li and Liu, 2016 ; Zhu et al, 2017 ). Pharmacological tests have also demonstrated the pharmacological activities of T. kirilowii in anti-tumor, anti-oxidation, neuroprotection, lowering blood lipids, and reducing kidney damage ( Lv et al, 2018 ; Lu et al, 2019 ; Hou et al, 2020 ; Ku et al, 2020 ). However, cultivated T. kirilowii plants are constantly attacked by a variety of plant diseases, posing a serious threat to the T. kirilowii industry ( Li and Zhang, 2007 ; Zhang et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

A Distinct Tobamovirus Associated With Trichosanthes kirilowii Mottle Mosaic Disease

Chen

Peng

et al. 2022

Front. Microbiol.

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Trichosanthes kirilowii is one of the most important perennial herbaceous vines that have been used in traditional Chinese medicine. In this study, a novel RNA virus was discovered in T. kirilowii plants showing leaf mottling and mosaic symptoms. The complete genome of this virus is 6,524 nucleotides long and encodes four open reading frames which are arranged in a manner typical of tobamoviruses. Phylogenetic analysis based on the complete genome sequence revealed that the virus was clustered into a branch with the tobamoviruses whose natural host are plants belonging to the family Cucurbitaceae. A full-length infectious cDNA clone was then constructed and demonstrated to establish a systemic infection with typical symptoms in Nicotiana benthamiana, T. kirilowii, and five other cucurbitaceous crops including Cucumis melo, C. lanatus, C. sativus, Luffa aegyptiaca, and Cucurbita pepo via agrobacterium-mediated infectivity assays. Further experiments provided evidence that the rod-shaped viral particles derived from the infectious clone could be mechanically transmitted and reproduce indistinguishable symptoms in the tested plants. Taken together, the mottle mosaic disease of T. kirilowii is caused by a distinct tobamovirus, for which the name Trichosanthes mottle mosaic virus (TrMMV) is proposed. As the infectious cDNA clone of TrMMV could also infect five other cucurbit crops, this distinct tobamovirus could be a potential threat to other cucurbitaceous crops.

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Hypolipidemic and antioxidant activities ofTrichosanthes kirilowiimaxim seed oil and flavonoids in mice fed with a high‐fat diet

Cited by 11 publications

References 48 publications

Antiobesity Activity of Two Polyherbal Formulations in High-Fat Diet-Induced Obese C57BL/6J Mice

Antiobesity Activity of Two Polyherbal Formulations in High-Fat Diet-Induced Obese C57BL/6J Mice

Designing combinational herbal drugs based on target space analysis

A Distinct Tobamovirus Associated With Trichosanthes kirilowii Mottle Mosaic Disease

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