Hypolipidemic Activity of 6-Substituted 6, 7-Dihydro-5H-dibenz[c,e]azepine and the effects of 6, 7-dihydro-5H-dibenz[c,e]azepine on Lipid Metabolism of Rodents

Asymmetric Reductive Amination/Ring-Closing Cascade: Direct Synthesis of Enantioenriched Biaryl-Bridged NH Lactams

“…Chiral amines with a biaryl-bridged aza-seven-membered ring represent a kind of structurally unique molecule which usually displays good bioactivities (Figure ). For example, compound A is a potent P-glycoprotein inhibitor, and compound B is considered as an allocolchicine analogue which functions as a microtubuline inhibitor . Remarkably, 5-ethylindolobenzazepinone C , a potent cytotoxic agent and tubulin polymerization inhibitor, exhibits promising antiproliferative activities in a variety of cancer cell lines (e.g., an IC 50 value of 32 nM in KB cells) .…”

Construction of 5H‐Dibenzo[c,e]azepine Framework from Dibenzothiophene Dioxides andN‐Benzylimines through SNAr Reactions

“…The 5 H ‐dibenzo[ c , e ]azepine framework is an azacyclic seven‐membered biphenyl that takes characteristic conformations, thereby having attracted increasing attention as the key precursors of bioactive compounds, [1–3] chiral catalysts, [4–6] and contorted π‐conjugated functional materials [7,8] . Methods for the construction of 5 H ‐dibenzo[ c , e ]azepines have hence been investigated [9,10] .…”

Intramolecular asymmetric reductive amination: synthesis of enantioenriched dibenz[c,e]azepines

“…Dibenz[ c , e ]azepines are a class of unique 7-membered cyclic amines featuring a biaryl bridge and have attracted increasing attention due to their importance in biological and synthetic chemistry 1. For instance, compound A is the active ingredient in an anti-obesity drug,2 and B is considered to be an allocolchicine analogue 3. In addition, dibenz[ c , e ]azepine-based compounds C , D , and E and compound F have found promising applications in either organocatalysis or asymmetric transition metal catalysis (eqn (a), Fig.…”