Hypoglycemic effect of &lt;i&gt; Swietenia macrophylla&lt;/i&gt; seeds against type II diabetes

Maiti, Anup; Dewanjee, Saikat; Jana, Goutam; Mandal, SubhashC

doi:10.4103/0973-8258.44738

Cited by 26 publications

(21 citation statements)

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“…[32] The effect of the fractions on cholesterol and triglyceride levels may be due to decrease in activity of enzymes involved in cholesterol biosynthesis or low levels of lipolysis which are in turn controlled by insulin. [33] The above findings confirm that the tested fractions have antidiabetic activity and are capable of correcting the altered biological parameters.…”

Section: Serum Insulinsupporting

confidence: 68%

Evaluation of the anti diabetic activity of column fractions obtained from the bark extract of Soymida febrifuga A. Juss

Karunasree

Veeresham

Rao

et al. 2012

Pharmacognosy Journal

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Diabetes has become a worldwide problem afflicting humans irrespective of age. Even though a number of synthetic drugs are available for the treatment of diabetes, plant drugs are generally preferred due to the assumption that they have less side effects and low cost. This study reports the hypoglycaemic and antihyperglycaemic actions of the methanolic bark extract of Soymida febrifuga A. Juss. (fam: Meliaceae) in euglycaemic and alloxan-induced diabetic rats, respectively. The results revealed that three column fractions obtained from the methanol extract of S. febrifuga possess maximum hypoglycaemic and antihyperglycaemic activities 6 h after treatment. At a dose of 200 mg/kg, the relatively nonpolar column fraction obtained by using 20% chloroform in acetone as an eluent was by far the most potent fraction which showed comparable activity with that of the standard drug glibenclamide (10 mg/kg). At a dose of 200 mg/kg, the same column eluate showed maximum antihyperglycaemic effect reducing blood glucose level by 33.00%. At a dose of 10 mg/kg, the reference drug glibenclamide brought about 33.46% reduction of blood glucose level. In light of the results obtained from the current study, it could be concluded that the bark of S. febrifuga has genuine antidiabetic activity.

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Section: Serum Insulinsupporting

confidence: 68%

Evaluation of the anti diabetic activity of column fractions obtained from the bark extract of Soymida febrifuga A. Juss

Karunasree

Veeresham

Rao

et al. 2012

Pharmacognosy Journal

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show abstract

“…However, the pharmacological drugs are either too expensive or have undesirable side effects or contraindications [4] . Throughout the world, many traditional plant treatments for diabetes exist, and therein lies a hidden wealth of potentially useful natural products for the control of diabetes [5] . Natural plant drugs are frequently considered to be less toxic and more free from side effects than synthetic ones [6] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats

Ananda¹,

Kumarappan²,

Sunil³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…Throughout the world, many traditional plant treatments for diabetes exist, and therein lies a hidden wealth of potentially useful natural products for the control of diabetes [10] . Natural plant drugs are frequently considered to be less toxic and freer from side effects than synthetic ones [11] .…”

Section: Lipid Peroxidation Streptozotocinmentioning

confidence: 99%

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

Ramesh

Rasineni

Sreenivasa

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Hypoglycemic effect of <i> Swietenia macrophylla</i> seeds against type II diabetes

Cited by 26 publications

References 0 publications

Evaluation of the anti diabetic activity of column fractions obtained from the bark extract of Soymida febrifuga A. Juss

Evaluation of the anti diabetic activity of column fractions obtained from the bark extract of Soymida febrifuga A. Juss

Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

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