Hypoglycemia in Infancy Caused by Beta Cell Nesidioblastosis

Idiopathic hypoglycaemia in sibs with morphological evidence of nesidioblastosis of the pancreas.

“…As in other reported cases (Yakovac et al, 1971;Grampa et al, 1974;Davidson et al, 1974;Sovik et al, 1975;Brown and Young, 1970), both children presented clinically with hypoglycaemia in the presence of hyperinsulinism, and both responded to treatment with diazoxide which suppresses insulin release . Also, as previously described (Sovik et al, 1975;Hamilton et al, 1967), subtotal pancreatectomy was required for complete control.…”

Idiopathic hypoglycaemia in sibs with morphological evidence of nesidioblastosis of the pancreas.

“…As in other reported cases (Yakovac et al, 1971;Grampa et al, 1974;Davidson et al, 1974;Sovik et al, 1975;Brown and Young, 1970), both children presented clinically with hypoglycaemia in the presence of hyperinsulinism, and both responded to treatment with diazoxide which suppresses insulin release . Also, as previously described (Sovik et al, 1975;Hamilton et al, 1967), subtotal pancreatectomy was required for complete control.…”

Morphological aspects of the endocrine pancreas in a prednisolone‐treated infant

“…Furthermore, the particular disposition of B cells surrounding the lumen, as observed in this study, is also found in steroid-treated animals (Lazarus & Volk 1962a), indicating a presumed B cell origin from ductular epithelium. Several authors (Laidlaw 1938, Frantz 1959, Yakovac, Baker & Hummerler 1971, Grampa, Gargantini, Grigolato & Chiumello 1974 have used the term 'nesidioblastosis' to emphasize the duct/islets relationship, when a diffuse proliferation of islet cells involves ductular epithelium. It is believed that Endocrine pancreatic hyperprasia 207 human insulinomas originate by direct ductular epithelial transition as an exaggeration of this phenomenon (Lazarus & Volk 1962b, Casanova, Guidon & Laffargue 1975, Carney 1976.…”

Relevance of Endocrine Pancreas Nesidioblastosis to Hyperinsulinemic Hypoglycemia

“…Instead, a diffuse and disseminated proliferation of islet cells budding off from pancreatic ducts is usually observed and has been proposed repeatedly as the underlying pathological lesion (8)(9)(10)(11)(12)(14)(15)(16)(17). The term nesidioblastosis, currently used to describe this condition, was originally coined by Laidlaw (18) because pancreatic endocrine tumors originate from nesidioblasts, the stem cells that differentiate from the duct.…”

Idiopathic hypoglycaemia in sibs with morphological evidence of nesidioblastosis of the pancreas.

“…As in other reported cases (Yakovac et al, 1971;Grampa et al, 1974;Davidson et al, 1974;Sovik et al, 1975;Brown and Young, 1970), both children presented clinically with hypoglycaemia in the presence of hyperinsulinism, and both responded to treatment with diazoxide which suppresses insulin release . Also, as previously described (Sovik et al, 1975;Hamilton et al, 1967), subtotal pancreatectomy was required for complete control.…”

Morphological aspects of the endocrine pancreas in a prednisolone‐treated infant

“…Furthermore, the particular disposition of B cells surrounding the lumen, as observed in this study, is also found in steroid-treated animals (Lazarus & Volk 1962a), indicating a presumed B cell origin from ductular epithelium. Several authors (Laidlaw 1938, Frantz 1959, Yakovac, Baker & Hummerler 1971, Grampa, Gargantini, Grigolato & Chiumello 1974 have used the term 'nesidioblastosis' to emphasize the duct/islets relationship, when a diffuse proliferation of islet cells involves ductular epithelium. It is believed that Endocrine pancreatic hyperprasia 207 human insulinomas originate by direct ductular epithelial transition as an exaggeration of this phenomenon (Lazarus & Volk 1962b, Casanova, Guidon & Laffargue 1975, Carney 1976.…”

Relevance of Endocrine Pancreas Nesidioblastosis to Hyperinsulinemic Hypoglycemia

“…Instead, a diffuse and disseminated proliferation of islet cells budding off from pancreatic ducts is usually observed and has been proposed repeatedly as the underlying pathological lesion (8)(9)(10)(11)(12)(14)(15)(16)(17). The term nesidioblastosis, currently used to describe this condition, was originally coined by Laidlaw (18) because pancreatic endocrine tumors originate from nesidioblasts, the stem cells that differentiate from the duct.…”

Idiopathic hypoglycaemia in sibs with morphological evidence of nesidioblastosis of the pancreas.

“…As in other reported cases (Yakovac et al, 1971;Grampa et al, 1974;Davidson et al, 1974;Sovik et al, 1975;Brown and Young, 1970), both children presented clinically with hypoglycaemia in the presence of hyperinsulinism, and both responded to treatment with diazoxide which suppresses insulin release . Also, as previously described (Sovik et al, 1975;Hamilton et al, 1967), subtotal pancreatectomy was required for complete control.…”

Morphological aspects of the endocrine pancreas in a prednisolone‐treated infant

“…Furthermore, the particular disposition of B cells surrounding the lumen, as observed in this study, is also found in steroid-treated animals (Lazarus & Volk 1962a), indicating a presumed B cell origin from ductular epithelium. Several authors (Laidlaw 1938, Frantz 1959, Yakovac, Baker & Hummerler 1971, Grampa, Gargantini, Grigolato & Chiumello 1974 have used the term 'nesidioblastosis' to emphasize the duct/islets relationship, when a diffuse proliferation of islet cells involves ductular epithelium. It is believed that Endocrine pancreatic hyperprasia 207 human insulinomas originate by direct ductular epithelial transition as an exaggeration of this phenomenon (Lazarus & Volk 1962b, Casanova, Guidon & Laffargue 1975, Carney 1976.…”

Relevance of Endocrine Pancreas Nesidioblastosis to Hyperinsulinemic Hypoglycemia

“…Instead, a diffuse and disseminated proliferation of islet cells budding off from pancreatic ducts is usually observed and has been proposed repeatedly as the underlying pathological lesion (8)(9)(10)(11)(12)(14)(15)(16)(17). The term nesidioblastosis, currently used to describe this condition, was originally coined by Laidlaw (18) because pancreatic endocrine tumors originate from nesidioblasts, the stem cells that differentiate from the duct.…”