Hypoglycaemic effect of resveratrol in streptozotocin-induced diabetic rats is impaired when supplemented in association with leucine

Avila, Liohanna Silva Pires D; Oliveira, Keciane Alves de; Abreu, Ewerton Sousa de; Vasconcelos, Raimundo Pereira de; Nascimento, Jessica de Freitas; Pontes, Edivânia Oliveira Bezerra; Rickli, Sarah; Coelho‐de‐Souza, Andrelina Noronha; Leal‐Cardoso, J. H.; Silveira, Leonardo R.; Carneiro, Everardo M.; Carvalho, Denise P.; Leal, Francisco; Oliveira, Ariclécio Cunha de

doi:10.1080/09637486.2019.1687660

Cited by 3 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other important interaction observed in vitro was resveratrol increasing the intracellular level of berberine in hepatic L02 cells and their combination showed much pronounced LDL receptor expression in HepG2 cells than either of the compounds alone [66]. Since resveratrol is a known antioxidant compound with specific effects in cell signalling including adenosine monophosphate (AMP)-activated protein kinase (AMPK) and nuclear factor erythroid 2-related factor 2 (Nrf2) activation [69,70] and antidiabetic effect in various models [71][72][73][74][75][76], its combination studies with berberine appear to be a reasonable strategy.…”

Section: From Drug Combination To Structural Linkage With Other Bioacmentioning

confidence: 99%

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Habtemariam

2020

Biomedicines

View full text Add to dashboard Cite

Berberine is a quaternary isoquinoline alkaloid that has been isolated from numerous plants which are still in use today as medicine and herbal supplements. The great deal of enthusiasm for intense research on berberine to date is based on its diverse pharmacological effects via action on multiple biological targets. Its poor bioavailability resulting from low intestinal absorption coupled with its efflux by the action of P-glycoprotein is, however, the major limitation. In this communication, the chemical approach of improving berberine’s bioavailability and pharmacological efficacy is scrutinised with specific reference to type-2 diabetes and associated diseases such as hyperlipidaemia and obesity. The application of modern delivery systems, research from combination studies to preparation of berberine structural hybrids with known biologically active compounds (antidiabetic, antihyperlipidaemic and antioxidant), as well as synthesis approaches of berberine derivative are presented. Improvement of bioavailability and efficacy through in vitro and ex vivo transport studies, as well as animal models of bioavailability/efficacy in lipid metabolism and diabetes targets are discussed.

show abstract

Section: From Drug Combination To Structural Linkage With Other Bioacmentioning

confidence: 99%

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Habtemariam

2020

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Resveratrol (RES) is a natural polyphenol molecule with anti‐inflammatory (Gambini et al., 2015; Pujara et al., 2021; Vella et al., 2015; Wahab et al., 2017), antioxidant (Schlich et al., 2020; Wang, Zhao, et al., 2020), anticancer (Chaudhary et al., 2019; Lin et al., 2020; Liu et al., 2020; Yin et al., 2020), hepatoprotection (Lee et al., 2012) effects. In addition, RES can improve metabolic disorders in diabetic rats (Liohanna et al., 2020). RES also has antiobesity effects, that could significantly improve metabolic phenotype and intestinal oxidative stress in the high‐fat diet‐fed mice (Wang, Zhao, et al., 2020; Wang, Gao, et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Shi

Wang

Tang

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

Resveratrol (RES) loaded Zein‐SHA (low‐molecular‐weight sodium hyaluronate) nanoparticles with average diameter of about 152.13 nm and polydispersity index (PDI) of 0.122, which can be used to encapsulate, protect and deliver resveratrol. By measuring ABTS free radical scavenging ability and iron (III) reducing power, it was determined that encapsulated resveratrol has higher in vitro antioxidant activity than free resveratrol. When tested with murine breast cancer cells 4T1, the encapsulated resveratrol also showed higher antiproliferative activity than free resveratrol, with IC50 values of 14.73 and 17.84 μg/ml, respectively. The colloidal form of resveratrol developed in this research may be particularly suitable for functional foods and beverages, as well as dietary supplements and pharmaceutical products.

show abstract

“…In our study, exercise slightly increased AMPK phosphorylation (data are not shown here) and significantly increased the expression of GLUT4 level in the muscle of LFD-fed mice. Actually, ATP produced by metabolism during exercise affects the expression of AMPK (39). AMPK activation of the muscles increases rapidly during exercise (40), which is related to the duration and intensity of exercise (41).…”

Section: Discussionmentioning

confidence: 99%

“…The principle is that high serum leucine levels can activate mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which leads to inhibition of glucose transport in the muscle and adipose tissue (43) and further promotes insulin resistance and obesity (45). Leucine was reported to impair the beneficial effects from resveratrol in diabetic rats (39). However, other studies found that leucine would reduce insulin resistance (18,46).…”

Section: Discussionmentioning

confidence: 99%

Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice

Jiang

Zhang

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveObesity-related diseases such as diabetes, hypertension, dyslipidemia, and cardiovascular diseases have increased due to the obesity epidemic. Early intervention for obesity through lifestyle and nutrition plays an important role in preventing obesity-related diseases. Therefore, the purpose of this study is to explore the role of leucine and exercise in adiposity, systemic insulin resistance, and inflammation to provide theoretical and guiding basis for the early prevention and treatment of obesity.MethodsC57BL/6J male mice were randomly divided into HFD or LFD-fed mice group. After 9 weeks, glucose tolerance test (GTT) was performed to detect their systemic insulin sensitivity. Starting from week 10, mice were divided into eight groups and treated with moderate exercise or/and 1.5% leucine. At week 13, systemic insulin sensitivity was detected by GTT. At week 14, mice were dissected to analyze adiposity and inflammation.ResultsIn LFD mice, exercise significantly increased systemic insulin sensitivity by increasing GLUT4 expression in the muscle and decreasing adiposity through increasing AMPK phosphorylation in adipose tissue. In HFD mice, the simultaneous intervention of exercise and leucine increases systemic insulin sensitivity by reducing liver and adipose tissue inflammation via decreasing NF-κB p65 phosphorylation, and increasing the expression of adiponectin in adipose tissue.ConclusionThere are different mechanisms underlying the effects of exercise and leucine on insulin resistance and inflammation in LFD-fed mice or HFD-fed mice.

show abstract

Hypoglycaemic effect of resveratrol in streptozotocin-induced diabetic rats is impaired when supplemented in association with leucine

Cited by 3 publications

References 27 publications

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice

Contact Info

Product

Resources

About