Hypodontia and ovarian cancer: A systematic review

Abstract

Spanish were excluded from this review. The retrieved data from each of the included studies were focused on the publication type, the number of patients included in each study, the number of patients included in the control group, the incidence of hypodontia, the number of missing teeth, the type of missing teeth, the distribution of hypodontia, the presence of ovarian cancer in family medical history, and the presence of isolated genes correlated to ovarian cancer. ResultsThe performed search in PubMed and Scopus revealed a total of 43 and 39 search results, respectively, among which 4 studies (4 case series) were identified as eligible for inclusion in this review, according to the inclusion criteria (8)(9)(10)(11). No additional studies were identified by searching the references of the included studies. The selected studies for inclusion are presented in detail in Figure 1 (flow diagram). The principal characteristics of the included studies in our review (publication type, number of patients, control group, incidence of hypodontia, number of missing teeth, type of missHypodontia can be defined as the non-formation of one or more teeth during the developmental period. Mutation in several genes related to tooth formation has previously been correlated with cancer. Regarding the ovarian cancer, there are few studies that associate the presence of hypodontia with ovarian cancer. A systematic literature search was performed in PubMed and Scopus. In total, 385 patients were included in this study. Control group was present in 3 out of 4 studies (340 patients). Hypodontia was present in 56 out of 290 patients (incidence of 19.3%). Only in 2 out of 4 studies, the number of missing teeth was mentioned (47 teeth), while the majority of them were either maxillary second premolars or maxillary lateral incisors. Unilateral distribution of the missing teeth was present in 28 out of 46 patients, while bilateral distribution of the missing teeth was present in 18 out of 46 patients. The presence of ovarian cancer in the family medical history occurred in 12 out of 33 patients. Only 1 out of 4 studies examined the presence of genes with mutations in the included patients. Based on our findings, the lack of clinical studies was the principal obstacle to clarify the possible predictive value of hypodontia in the early prediction of patients with higher risk of ovarian cancer. (J Turk Ger Gynecol Assoc 2016; 17: 41-4) Keywords: Hypodontia Abstract ing teeth, distribution of hypodontia, presence of ovarian cancer in family medical history, and isolated genes) are presented in Table 1. In total, 385 patients were included in this study. Control group was present in 3 out of 4 studies (340 patients). Hypodontia was present in 56 out of 290 patients (19.3%). Only in 2 out of 4 studies, the number of missing teeth was mentioned (47 teeth), and the majority of them were either maxillary second premolars or maxillary lateral incisors. Unilateral distribution of the missing teeth was present in 28 out of 46 patients, while bilater...

Tooth agenesis: What do we know and is there a connection to cancer?

“…In addition to family and association studies, epidemiological data on tooth agenesis and cancer were collected in five original articles 71‐75 (discussed below) and four reviews 76‐79 . However, these reviews are based only on epidemiological data of mentioned five sources.…”

Diagnosis of Tooth Agenesis in Childhood and Risk for Neoplasms in Adulthood

“…1 The reported incidence of tooth agenesis is 3%-10% depending on the population being studied. [2][3][4] The incidence is higher in females, and 60% of individuals exhibit unilateral tooth agenesis. 3 Third molars are the most commonly missing permanent teeth; 23% is the often-cited incidence rate.…”

Coexistence of tooth agenesis and ovarian cancer — a systematic literature review

“…Despite these data, from 2014 to September 2018, no new research publications confirmed the hypothesis of the coincidence of hypodontia and ovarian cancer. In 2016, a review paper by Iavazzo was published on the relationship between ovarian cancer and hypodontia; this qualified four publications for review [28], one of which was the publication of Fekonja et al from 2015, which is a description of a study whose results were published a year earlier [27,29], as can be seen from the location and year of the study, the size of the study and control group, and the frequency of hypodontia in both groups. This publication was therefore excluded from our review; it did, however, aim to compare data on the stage of advancement and the type of cancer in patients with and without hypodontia [29].…”