J. Neurosci. Res. volume 86, issue 2, P465-470 2008 DOI: 10.1002/jnr.21499 View full text
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Yin Fang Xu, You Qing Cai, Guo Qiang Cai, Jie Jiang, Zhe Jing Sheng, Zhu Gang Wang, Jian Fei

Abstract: gamma-Aminobutyric acid (GABA) transporters play a key role in the regulation of GABA neurotransmission. We reported previously that overexpression of the GABA transporter subtype 1 (GAT1), the major form of the GABA transporter in the CNS, led to hyperalgesia in mice. In the present study, nociceptive responses of GAT1-knockout mice (GAT1(-/-)) were compared with those of heterozygous (GAT(+/-)) and wild-type (GAT(+/+)) mice by four conventional pain models (tail-immersion test, hot-plate test, acetic acid-in…

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