Hypertrophic Cardiomyopathy During Corticotropin Therapy for Infantile Spasms

Effects of Adrenocorticotropic Hormone Treatment on Heart Muscle in Patients with Infantile Spasm

“…In these five cases, the systolic anterior motion of the mitral valve observed during systole without left ventricle outflow tract obstruction. These data are in concordance with our findings, but contrary to our study, they identified concentric hypertrophy in eight patients, which was associated with systemic blood pressure elevation [7].…”

Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms

“…Among the 16 echocardiograms performed, 1 showed mild septal hypertrophy and 2 demonstrated mild concentric hypertrophy. This is significantly different from the rates reported by Bobele et al, 22 who evaluated patients on ACTH with serial echocardiograms. They evaluated cardiac hypertrophy using measurements of the intraventricular septum and posterior left ventricle wall.…”

Retrospective Echocardiographic Analysis of West Syndrome During Adrenocorticotropic Hormone Therapy

“…Both the IVSd and LVPWd thickened markedly at week 1; then, the LVPWd leveled off, but the IVSd tended to increase during therapy. Previous studies demonstrated echocardiographically that the time to the onset of hypertrophic cardiomyopathy was 8 weeks ( 9 ) while the left ventricular free wall and septal wall dimensions increased from 13 to 46 days after the commencement of therapy ( 5 ) and that significant changes occurred earlier than in the present study. However, these reports assessed the changes at a minimum of 13 days after the commencement of therapy.…”