Hypertriglyceridemic waist phenotype in primary health care: comparison of two cutoff points

Abstract

ObjectiveWe aimed to evaluate the prevalence of hypertriglyceridemic waist (HTGW) phenotype among users of primary health care using two different cutoff points used in the literature.MethodsWe evaluated adults and elderly individuals of both sexes who attended the same level of primary health care. HTGW phenotype was determined with measurements of waist circumference (WC) and triglyceride levels and compared using cutoff points proposed by the National Cholesterol Education Program – NCEP/ATP III (WC ≥102 cm for men and ≥88 cm for women; triglyceride levels ≥150 mg/dL for both sexes) and by Lemieux et al (WC ≥90 cm for men and ≥85 cm for women; triglyceride levels ≥177 mg/dL for both).ResultsWithin the sample of 437 individuals, 73.7% was female. The prevalence of HTGW phenotype was high and statistically different with the use of different cutoff points from the literature. The prevalence was higher using the NCEP/ATP III criteria compared to those proposed by Lemieux et al (36.2% and 32.5%, respectively, p<0.05). Individuals with the presence of the phenotype also presented alterations in other traditional cardiovascular risk markers.ConclusionThe HTGW phenotype identified high prevalence of cardiovascular risk in the population, with higher cutoff points from the NCEP/ATP III criteria. The difference in frequency of risk alerts us to the need to establish cutoff points for the Brazilian population.

Prevalence And Factors Associated With Hypertriglyceridemic Waist In Colombian Elderly.

“…The strongly positive association between HTGW with the female sex, age, body mass index and high blood glucose levels, agree with that found in Brazilian older adults (24,32)This association makes clear the importance of anthropometric indicators as indirect evidence of metabolic disorders, since it has been shown that the increase in body volume provides an environment conducive to the development of metabolic disorders especially in women, after the menopause, period in which women reduce their levels of physical activity, increase their social stress and adopt inappropriate nutritional styles, which ultimately leads to an increase in body weight (35). The inverse association between smoking and HTGW is surprising in our study, although it has been reported that the cessation of smoking is linked to the increase in body weight and adiposity indexes (36).…”

“…The results of Colombia are also similar to those previously mentioned, in terms of higher percentages of prevalence in older adults nonsmokers, obese, with glycemia ≥ 100 mg / dL and total cholesterol ≥ 200 mg / dL. This fact is worrisome given the increase in older adults population around the world, cardiovascular risk, subclinical atherosclerosis and chronic kidney disease associated with this phenotype (30)(31)(32). On the other hand, and in line with the Brazilian results(24), a higher prevalence of HTGW was found in Colombians older than 70 years of age.…”

The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits

“…Some authors have warned that the criterion for hypertriglyceridemia has changed from ≥ 150 mg/dL to ≥ 175 mg/dL 46 . Moreover, a recent study has proven that WC * TG is a useful marker for the identification of cardiovascular risk 22 . Another trial showed that the TyG index can predict incident hypertension, which supports our findings that triglycerides are linked to hypertension 47 .…”

“…Previous studies have assessed the associations of some of the aforementioned indicators with the prevalence of type 2 diabetes, coronary heart disease and liver disease, however there is a lack of studies concerning the definition of reference values based on combined anthropometric and biochemical indices, where excessive adiposity and lipid/glucose metabolism impairments coexist 19 – 22 . Indeed, a relation between fatty acids and waist circumference with metabolic health have been established 23 .…”

Association Between Lifestyle and Hypertriglyceridemic Waist Phenotype in the PREDIMED‐Plus Study

“…Few studies have analyzed the presence of the HTGW phenotype in the adult population, and cutoff points for defining it have yet to be determined . The HTGW phenotype has been used to identify individuals who are susceptible to being at greater risk of cardiometabolic disorders such as high BMI, elevated C‐reactive protein, increased total cholesterol, decreased high‐density lipoprotein cholesterol (HDLc), and elevated low‐density lipoprotein cholesterol (LDLc) .…”