Hyperthyroidism, Pretibial Myxedema, and Clubbing

Malkinson, Frederick D.

doi:10.1001/archderm.1963.01590210061009

Arch Dermatol

1963

DOI: 10.1001/archderm.1963.01590210061009

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Hyperthyroidism, Pretibial Myxedema, and Clubbing

Frederick D. Malkinson¹

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Cited by 24 publications

(9 citation statements)

References 38 publications

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“…The syndrome of hyperthyroidism, exophthalmos, pretibial myxoedema and acropachy is well described (Malkinson, 1963) but very rare and only about 37 cases can be found in the English literature. This syndrome coupled with the controversial role of the recently discovered long‐acting thyroid stimulator — LATS (Adams, 1958) exemplifies the complex aspects of the pathogenesis of hyperthyroidism.…”

mentioning

confidence: 99%

LATS Activity, Hyperthyroidism, Exophthalmos, Pretibial Myxoedema and Acropachy

Bartholomew

¹

1972

Int J Clinical Practice

2

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The syndrome of hyperthyroidism, exophthalmos, pretibial myxoedema and acropachy is well described (Malkinson, 1963) but very rare and only about 37 cases can be found in the English literature. This syndrome coupled with the controversial role of the recently discovered long‐acting thyroid stimulator — LATS (Adams, 1958) exemplifies the complex aspects of the pathogenesis of hyperthyroidism.…”

mentioning

confidence: 99%

LATS Activity, Hyperthyroidism, Exophthalmos, Pretibial Myxoedema and Acropachy

Bartholomew

¹

1972

Int J Clinical Practice

2

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…clubbing with thyrotoxicosis is well known (Malkinson, 1963). It has been postulated that the long acting thyroid stimulator (LATS) might be the common aetiological factor.…”

mentioning

confidence: 99%

LATS activity, exophthalmos and digital clubbing associated with myxoedema

Beighton

¹

1968

Postgraduate Medical Journal

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The position of acropachy seems more uncertain. The diffuse swelling that may be seen over the hands could be primarily due to mucopolysaccharide deposition (Malkinson 1963).…”

mentioning

confidence: 99%

“…The radiological appearance suggests bubbles on the bone surface rather than a thin shell of new bone formation. Malkinson (1963) reviewed 26 cases of hyperthyroidism, pretibial myxocdema and clubbing reported in the literature. He also discussed the then current speculations on the factors responsible for this syndrome.…”

mentioning

confidence: 99%

“…Malkinson (1963) reviewed 26 cases of hyperthyroidism, pretibial myxoedema and clubbing reported in the literature. He also discussed the then current speculations on the factors responsible for this syndrome.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Pretibial Myxoedema

Keir¹

1968

Int J Clinical Practice

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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