Hyperthymic temperament and brightness judgment in healthy subjects: Involvement of left inferior orbitofrontal cortex

Asymmetrical frontal cortical activity associated with differential risk for mood and anxiety disorder symptoms: An RDoC perspective

“…In studies that have employed fMRI reward paradigms, the most reliable finding is that bipolar individuals display an abnormal increase in left lateral OFC activation during reward processing. This has been observed across the entire bipolar spectrum and among individuals at risk for bipolar disorder (Nusslock et al, 2012a;Bermpohl, et al, 2010;Chase et al, 2013;Caseras, et al, 2013;Harada, et al, 2013). Elevated left lateral OFC activation during reward processing in fMRI studies has also been observed across all phases of bipolar disorder, including mania (Bermpohl et al, 2010), euthymia (Nusslock et al, 2012a), and depression (Chase et al, 2013).…”

“…Bipolar I individuals in remission (Nusslock et al, 2012a) and in a manic episode (Bermpohl et al, 2010;Abler et al, 2008) display elevated ventral striatal and left lateral OFC (BA 47) activation during reward processing compared to healthy controls. Abnormally elevated ventral striatal and left lateral OFC activation has also been observed in bipolar II individuals in remission (Caseras et al, 2013) and individuals with a hyperthymic temperament who have not yet developed the illness but who are at elevated risk (Harada et al, 2013). This latter finding suggests that elevated functional reward-related neural activation may reflect a preexisting risk factor for bipolar disorder, as opposed to a consequence of the illness.…”

Hyperthymic temperament and rapid reaction time in brightness preference

“…As previously detailed (Harada et al, 2013a(Harada et al, , 2013b, we used the Temperament Scale of Memphis, Pisa, Paris and San DiegoAutoquestionnaire (TEMPS-A) developed by Akiskal et al (2005) to measure affective temperament. This scale has 110 questions that gauge 5 temperaments (depressive, hyperthymic, cyclothymic, irritable and anxious), has been verified in 32 languages, and has been widely used in a number of epidemiological and clinical studies with psychiatric patients and healthy subjects.…”

“…Following from previous experimental studies examining brightness judgment (Harada et al, 2013a) and brightness preference (Harada et al, 2013b) in relation to hyperthymic temperament, we newly examined reaction time (RT) data generated from these experiments to investigate the hypothesis that hyperthymic temperament is associated with rapid processing in decisions of requiring subjects to judge and indicate preferences of illuminance. Moreover, the previous studies (Harada et al, 2013a(Harada et al, , 2013b suggest the left inferior orbitofrontal cortex as one of neural correlates of hyperthymic temperament and therefore percent signal changes of the region of interest (ROI) were measured and analyzed in relation to RT.…”

“…Moreover, the previous studies (Harada et al, 2013a(Harada et al, , 2013b suggest the left inferior orbitofrontal cortex as one of neural correlates of hyperthymic temperament and therefore percent signal changes of the region of interest (ROI) were measured and analyzed in relation to RT.…”