Hypertensive Breakdown of Cerebral but Not of Retinal Blood Vessels in Rhesus Monkey

Ultrastructural changes in cerebral pericytes and astrocytes of stroke-prone spontaneously hypertensive rats.

“…Therefore, the degeneration of filamentous pericytes in SHRSP may be caused by reduced cerebral blood flow just as medial smooth muscle cells degenerate as blood flow decreases. In one study, 11 acute hypertension caused the blood-brain barrier to break down, whereas the blood-retinal barrier (which contains a higher density •^~-,,- of pericytes) remained intact and undamaged. Stewart et al 12 examined living, structurally normal brains from patients of various ages at biopsy.…”

Ultrastructural changes in cerebral pericytes and astrocytes of stroke-prone spontaneously hypertensive rats.

“…Therefore, the degeneration of filamentous pericytes in SHRSP may be caused by reduced cerebral blood flow just as medial smooth muscle cells degenerate as blood flow decreases. In one study, 11 acute hypertension caused the blood-brain barrier to break down, whereas the blood-retinal barrier (which contains a higher density •^~-,,- of pericytes) remained intact and undamaged. Stewart et al 12 examined living, structurally normal brains from patients of various ages at biopsy.…”

Morphology and Topography of Retinal Pericytes in the Living Mouse Retina Using In Vivo Adaptive Optics Imaging and Ex Vivo Characterization

“…20,21 Conversely, pericytes appear to have a lasting presence in conditions of hypertension, arteriosclerosis, and aging that exceeds that of their juxtaposed endothelial cells. 3,4 The full natural history that leads to pericyte preservation or loss in retinal disease is still not fully understood.…”

Pericytes: Cell Biology and Pathology

“…Hypertensive rats showed a 4-fold increase in pericytes in microvessels of the motor cortex and pericytes in the midbrain and pons were also increased. In a study of acute experimental hypertension in the rat, Laties et al [1979] showed that vascular permeability, indicated by Evans blue extravasation, occurred in brain capillaries but not in retinal capillaries. Retinal capillaries have a greater coverage of pericytes than brain capillaries (see Morphology above).…”

Ultrastructural changes in cerebral pericytes and astrocytes of stroke-prone spontaneously hypertensive rats.

“…Therefore, the degeneration of filamentous pericytes in SHRSP may be caused by reduced cerebral blood flow just as medial smooth muscle cells degenerate as blood flow decreases. In one study, 11 acute hypertension caused the blood-brain barrier to break down, whereas the blood-retinal barrier (which contains a higher density •^~-,,- of pericytes) remained intact and undamaged. Stewart et al 12 examined living, structurally normal brains from patients of various ages at biopsy.…”

Morphology and Topography of Retinal Pericytes in the Living Mouse Retina Using In Vivo Adaptive Optics Imaging and Ex Vivo Characterization

“…20,21 Conversely, pericytes appear to have a lasting presence in conditions of hypertension, arteriosclerosis, and aging that exceeds that of their juxtaposed endothelial cells. 3,4 The full natural history that leads to pericyte preservation or loss in retinal disease is still not fully understood.…”

Pericytes: Cell Biology and Pathology

“…Hypertensive rats showed a 4-fold increase in pericytes in microvessels of the motor cortex and pericytes in the midbrain and pons were also increased. In a study of acute experimental hypertension in the rat, Laties et al [1979] showed that vascular permeability, indicated by Evans blue extravasation, occurred in brain capillaries but not in retinal capillaries. Retinal capillaries have a greater coverage of pericytes than brain capillaries (see Morphology above).…”

Ultrastructural changes in cerebral pericytes and astrocytes of stroke-prone spontaneously hypertensive rats.

“…Therefore, the degeneration of filamentous pericytes in SHRSP may be caused by reduced cerebral blood flow just as medial smooth muscle cells degenerate as blood flow decreases. In one study, 11 acute hypertension caused the blood-brain barrier to break down, whereas the blood-retinal barrier (which contains a higher density •^~-,,- of pericytes) remained intact and undamaged. Stewart et al 12 examined living, structurally normal brains from patients of various ages at biopsy.…”

Morphology and Topography of Retinal Pericytes in the Living Mouse Retina Using In Vivo Adaptive Optics Imaging and Ex Vivo Characterization

“…20,21 Conversely, pericytes appear to have a lasting presence in conditions of hypertension, arteriosclerosis, and aging that exceeds that of their juxtaposed endothelial cells. 3,4 The full natural history that leads to pericyte preservation or loss in retinal disease is still not fully understood.…”

Pericytes: Cell Biology and Pathology

“…Hypertensive rats showed a 4-fold increase in pericytes in microvessels of the motor cortex and pericytes in the midbrain and pons were also increased. In a study of acute experimental hypertension in the rat, Laties et al [1979] showed that vascular permeability, indicated by Evans blue extravasation, occurred in brain capillaries but not in retinal capillaries. Retinal capillaries have a greater coverage of pericytes than brain capillaries (see Morphology above).…”