Hypertension: Protective Effects of Physical Exercise on Cognition Function, Arterial Function and Brain Health

Abstract

Systemic Arterial Hypertension (SAH) is a chronic condition that requires clinical treatment and is associated with increased risk of cognitive impairment and dementia. Therefore, strategies with fewer side effects and less invasive procedures are required. Evidence supports that Physical Exercise (PE) has antihypertensive effects and has proven to be an efficient and complementary tool for managing hypertension, reducing cardiovascular disease risk factors, and improving cerebral perfusion in the majority of healthy populations. Much of this cardiovascular-protective effect of PE is probably due to pluripotent effects on the vasculature, including regulation of vascular tone, energy metabolism, microvascular recruitment, and endothelial function (reducing oxidative stress and preserving NO availability). These factors are speculated to work synergistically, thereby reducing systolic and diastolic blood pressure and are directly related to improved cerebrovascular function. However, few studies have specifically examined the potential positive effects of PE on the brain in hypertensive individuals. In this brief review, we discuss the potential effect of different PE modalities (aerobic, resistance, and combined) that may act as an effective preventive or therapeutic strategy for reducing blood pressure in hypertensives and, consequently, mitigate the association between hypertension, cognitive impairment and risk of dementia.

The Dose–Response Relationships of Different Dimensions of Physical Activity with Daily Physical Function and Cognitive Function in Chinese Adults with Hypertension: A Cross-Sectional Study

“…Epinephrine is involved in emotional memory consolidation. Exercise causes the release of adrenaline, glucocorticoid, and cortisol, which play neuroprotective roles by increasing the secretion of brain-derived neurotrophic factor, improving memory ability, and preventing neurologic dementia caused by hypertension [ 41 , 42 ]. Moreover, long-term low-intensity exercise can also improve aortic elasticity in patients with hypertension and can have a more positive impact on the CF and cardiovascular health of patients [ 43 ].…”

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“… Physical Exercise: Lake of physical activity is associated with a higher incidence of hypertension 10 .…”