Hypertension in pediatric patients with chronic kidney disease: management challenges

Gallibois, Claire; Jawa, Natasha; Noone, Damien

doi:10.2147/ijnrd.s100891

Cited by 36 publications

(22 citation statements)

References 114 publications

(174 reference statements)

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“…Comparatively, among those patients with adequate follow-up data, approximately half (4/7) of our patients had CKD. Adequate control of blood pressure and proteinuria is important in slowing the progression of CKD 19. Despite this, we note that 5 of 11 patients had prehypertension, hypertension or significant proteinuria at follow-up.…”

Section: Discussionmentioning

confidence: 75%

Pneumococcal haemolytic uraemic syndrome in the postvaccine era

Lawrence

Gwee

Quinlan³

2018

Arch Dis Child

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Section: Discussionmentioning

confidence: 75%

Pneumococcal haemolytic uraemic syndrome in the postvaccine era

Lawrence

Gwee

Quinlan³

2018

Arch Dis Child

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“…Detection of hypertension in children is important as it has been shown to have potentially severe consequences such as target organ damage including left ventricular hypertrophy, kidney damage and progression of chronic kidney disease, accelerated pathological vascular changes, and subtle neurological effects like reduced cognitive function [28, 29]. Whilst no long-term cohort studiers have directly linked hypertension in childhood to cardiovascular events in adults, it is well known that hypertension in childhood and adolescents tracks hypertension into adulthood [30].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Primary Hypertension and Risk Factors in Grade XII Learners in KwaZulu-Natal, South Africa

Bhimma

Naicker

Gounden

et al. 2018

International Journal of Hypertension

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Hypertension in childhood leads to hypertension in adult life, the strongest risk factor being obesity. This study determined the prevalence of primary hypertension and its risk factors in Grade XII learners in KwaZulu-Natal, South Africa, from March 2016 to June 2017. Weight, height, body mass index (BMI), random finger prick cholesterol and glucose, and spot urine for an albumin : creatinine ratio were measured. An average of three separate blood pressure readings taken was at least 5 minutes apart. Five hundred and sixty-four learners had weight, height, and BMI; 536 had random blood glucose; and 545 had cholesterol and random spot urine albumin : creatinine ratios measured. Prehypertension was detected in 168 (29.7%) and hypertension in 77 (13.7%) of learners. Ninety (15.9%) were overweight and 75 (13,3%) were obese. Hypercholesterolaemia was present in 58 (10.8%) and a high spot random urine albumin : creatinine ratio in 5 (1.0%). None had a high blood glucose level. Both prehypertension and hypertension in all learners showed a significant increase with increasing BMI. Six (1.0%) learners had metabolic syndrome. Female learners in other racial groups (defined as Indian, mixed race, and White learners), overweight, and obese learners showed significantly higher rates of hypercholesterolaemia. We showed overweight and obesity as risk factors for prehypertension and hypertension. This presages the need for an appropriate diet and adequate exercise in a child's school career.

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“…Hypothyroidism, for CKD 3-4 stage patients, is still considered to be an independent risk factor. The effect on glomerular filtration rate has been demonstrated in patients with hypothyroidism in previous studies (30).…”

Section: Discussionmentioning

confidence: 76%

Favorable Effect of Levothyroxine on Nutritional Status of Patients with Stage 3-4 Chronic Kidney Disease

Tang

Chen

et al. 2018

Acta Endo (Buc)

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The aim of this study was to analyze the incidence of malnutrition in patients with stage 3-4 chronic kidney disease (CKD) and primary subclinical hypothyroidism and the effect of levothyroxine for improving nutritional status and delaying kidney disease. Patients and Methods. In the study were included 200 patients with stage 3-4 CKD: CKD3 stage group (n=100) and CKD4 stage group (n=100). These patients were further divided into: control group (non-treatment group) group a (n=65) and experiment group (treatment group) group b (n=135) according to their levothyroxine treatment. The CKD3 stage group is divided into c3 (n=35) and e3 (n=65), and CKD4 group is divided into c4 (n=30) and e4 (n=70) groups. Results. Upon treatment of subclinical hypothyroidism with levothyroxine, nutritional indicators of patients are improved, and the weight, left and right-hand grip strength, hemoglobin (HB), serum albumin are higher compared to control. After levothyroxine treatment, eGFR in the treatment group increased with each time point, while in the control group it could be seen a significant decrease. This effect was more robust in the CKD3 group than in the CKD4 group. In conclusion, levothyroxine treatment can delay the progression of kidney diseases with more efficacy in stage 3 patients.

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Hypertension in pediatric patients with chronic kidney disease: management challenges

Cited by 36 publications

References 114 publications

Pneumococcal haemolytic uraemic syndrome in the postvaccine era

Pneumococcal haemolytic uraemic syndrome in the postvaccine era

Prevalence of Primary Hypertension and Risk Factors in Grade XII Learners in KwaZulu-Natal, South Africa

Favorable Effect of Levothyroxine on Nutritional Status of Patients with Stage 3-4 Chronic Kidney Disease

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