Hypertension in Chronic Kidney Disease: The Influence of Renal Transplantation.

Azancot, María A; Ramos, Natália; Moreso, Francesc; Ibernón, Meritxell; Espinel, Eugènia; Fort, Joan; Serón, Daniel

doi:10.1097/00007890-201407151-01728

Cited by 7 publications

(18 citation statements)

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“…In a previous study we described increased 24‐hour ABPM in kidney transplant recipients compared with CKD patients with similar renal function, but the reason for this difference remains unclear . In the present study, we observed an increased number of carotid plaques and increased IL‐6 levels in kidney transplant recipients.…”

Section: Discussionsupporting

confidence: 60%

“…Proteinuria has been associated with 24‐hour ABPM in kidney transplant recipients, while its relationship with circulating monocytes has not been described. In spontaneously hypertensive rats and in hypertensive patients, the number of circulating monocytes is increased .…”

Section: Discussionmentioning

confidence: 99%

“…ABPM was measured using an overnight‐automated ABPM monitor (Spacelab 90207; Spacelabs Healthcare, Snoqualmie, WA) with appropriate cuff sizes for each patient as previously described . The percentage decline of BP from day to night was calculated as ([awake SBP–sleep SBP]/awake SBP) × 100.…”

Section: Methodsmentioning

confidence: 99%

“…In kidney transplant recipients, reverse dipping ABPM pattern has been associated with outcome evaluated by means of a composite variable consisting of the combination of any cardiovascular event and graft failure for any reason . However, in a study comparing ABPM between transplant and CKD patients with similar renal function, transplantation was an independent predictor of the severity of hypertension, especially for sleep systolic BP (SBP) once corrected for confounding factors . The reason for this difference between transplant and CKD patients has not been studied.…”

mentioning

confidence: 99%

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Inflammation and Atherosclerosis Are Associated With Hypertension in Kidney Transplant Recipients

Azancot

Ramos

García-Carro

et al. 2015

J of Clinical Hypertension

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The aim of the current study was to evaluate risk factors associated with hypertension in kidney transplant recipients. The authors recruited 92 consecutive kidney transplant recipients and 30 age‐matched patients with chronic kidney disease without history of cardiovascular events. Twenty‐four–hour ambulatory blood pressure monitoring, pulse wave velocity, and carotid ultrasound were performed. Serum levels of log‐transformed interleukin 6 (Log IL‐6), soluble tumor necrosis factor receptor 2, and intercellular adhesion molecule 1 were determined. Twenty‐four–hour systolic blood pressure (SBP) (P=.0001), Log IL‐6 (P=.011), and total number of carotid plaques (P=.013) were higher, while the percentage decline of SBP from day to night was lower in kidney transplant recipients (P=.003). Independent predictors of 24‐hour SBP were urinary protein/creatinine ratio and circulating monocytes (P=.001), while Log IL‐6, serum creatinine, and total number of carotid plaques (P=.0001) were independent predictors of percentage decline of SBP from day to night. These results suggest that subclinical atherosclerosis and systemic inflammation are associated with hypertension after transplantation.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Inflammation and Atherosclerosis Are Associated With Hypertension in Kidney Transplant Recipients

Azancot

Ramos

García-Carro

et al. 2015

J of Clinical Hypertension

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“…31 In contrast to early CKD, hypertension in transplanted patients tends to be more severe when evaluated by ABPM than by CBP and is frequently associated with nocturnal hypertension and BP nondipping (the latter issue will be further developed in a twin manuscript separately published). 32 Only 16% of kidney recipients off antihypertensive drugs are truly normotensive (normal CBP and ABP levels), and ≈44% of those receiving antihypertensive treatment fail to achieve BP control when assessed by ABPM (ie, they are characterized by masked uncontrolled hypertension). 33 These findings, along with the frequent occurrence of MH, further point to the relevance of implementing ABPM also in the transplant population.…”

mentioning

confidence: 99%

Hypertension in Chronic Kidney Disease Part 1

et al. 2016

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Sex differences in ambulatory blood pressure levels, control, and phenotypes of hypertension in kidney transplant recipients

Korogiannou

Sarafidis

Theodorakopoulou

et al. 2021

Journal of Hypertension

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Objectives: Ambulatory blood pressure (BP) control is worse in men compared with women with chronic kidney disease (CKD) and this may partially explain the faster CKD progression in men. This is the first study investigating possible sex differences in prevalence, control and phenotypes of hypertension in kidney transplant recipients (KTRs) with office-BP and 24-h ambulatory BP monitoring (ABPM).Methods: This cross-sectional study included 136 male and 69 female stable KTRs who underwent office-BP measurements and 24-h ABPM. Hypertension thresholds for office and ambulatory BP were defined according to the 2017 ACC/AHA and 2021 KDIGO guidelines for KTRs.Results: Age, time from transplantation, eGFR and history of major comorbidities did not differ between groups. Office SBP/DBP levels were insignificantly higher in men than women (130.3 AE 16.3/77.3 AE 9.4 vs. 126.4 AE 17.8/ 74.9 AE 11.5 mmHg; P ¼ 0.118/0.104) but daytime SBP/DBP was significantly higher in men (128.5 AE 12.1/83.0 AE 8.2 vs. 124.6 AE 11.9/80.3 AE 9.3 mmHg; P ¼ 0.032/P ¼ 0.044). No significant between-group differences were detected for night-time BP. The prevalence of hypertension was similar by office-BP criteria (93.4 vs. 91.3%; P ¼ 0.589), but higher in men than women with ABPM (100 vs. 95.7%; P ¼ 0.014). The use of ACEIs/ARBs and CCBs was more common in men. Office-BP control was similar (43.3 vs. 44.4%, P ¼ 0.882), but 24-h control was significantly lower in men than women (16.9 vs. 30.3%; P ¼ 0.029). White-coat hypertension was similar (5.1 vs. 7.6%; P ¼ 0.493), whereas masked hypertension was insignificantly more prevalent in men than women (35.3 vs. 24.2%; P ¼ 0.113).Conclusion: BP levels, hypertension prevalence and control are similar by office criteria but significantly different by ABPM criteria between male and female KTRs. Worse ambulatory BP control in male compared with female KTRs may interfere with renal and cardiovascular outcomes.

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Hypertension in Chronic Kidney Disease: The Influence of Renal Transplantation.

Cited by 7 publications

References 0 publications

Inflammation and Atherosclerosis Are Associated With Hypertension in Kidney Transplant Recipients

Inflammation and Atherosclerosis Are Associated With Hypertension in Kidney Transplant Recipients

Hypertension in Chronic Kidney Disease Part 1

Sex differences in ambulatory blood pressure levels, control, and phenotypes of hypertension in kidney transplant recipients

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