Hypertension in Acute Ischemic Strokes

Community of protein complexes impacts disease association

“…The observed associations between diseases may help us to identify new comorbidity patterns along their potential genetic origin. After examining the entire set of 1953 disease pairs that are genetically linked in our results, we found some disease pairs whose comorbidity patterns are already well known to the medical community, for example, hypertension and ischemic stroke 26,27 or diabetes mellitus and chronic anemia. 28 These examples demonstrate that the capacity of the protein complex-based approach in identifying potentially interesting disease pairs is worth of further research.…”

Community of protein complexes impacts disease association

“…The observed associations between diseases may help us to identify new comorbidity patterns along their potential genetic origin. After examining the entire set of 1953 disease pairs that are genetically linked in our results, we found some disease pairs whose comorbidity patterns are already well known to the medical community, for example, hypertension and ischemic stroke 26,27 or diabetes mellitus and chronic anemia. 28 These examples demonstrate that the capacity of the protein complex-based approach in identifying potentially interesting disease pairs is worth of further research.…”

Elevated Blood Pressure in the Acute Phase of Stroke and the Role of Angiotensin Receptor Blockers

“…While the primary prevention of stroke through the treatment of hypertension is well established and evidence from randomized controlled trials suggests the use of antihypertensive agents for the secondary prevention of vascular events in patients with previous stroke or transient ischaemic attack, the management of BP immediately after stroke has been an enigmatic controversy for more than two decades, exemplified by a debate published back in 1985 [31], and still remains uncertain. In experimental studies on rats, candesartan has been shown to be neuroprotective with both reduction of neurovascular damage, demonstrated by decreased infarct size, hemoglobin content and oedema in the ischaemic brain hemisphere, and improvement of neurological outcome.…”

Manejo da hipertensão arterial na isquemia cerebral aguda

“…Assim, não havia indicação formal para redução imediata da TA à luz dos conhecimentos atuais 7,8,9,18,20,23 .…”

Community of protein complexes impacts disease association

“…The observed associations between diseases may help us to identify new comorbidity patterns along their potential genetic origin. After examining the entire set of 1953 disease pairs that are genetically linked in our results, we found some disease pairs whose comorbidity patterns are already well known to the medical community, for example, hypertension and ischemic stroke 26,27 or diabetes mellitus and chronic anemia. 28 These examples demonstrate that the capacity of the protein complex-based approach in identifying potentially interesting disease pairs is worth of further research.…”

Elevated Blood Pressure in the Acute Phase of Stroke and the Role of Angiotensin Receptor Blockers

“…While the primary prevention of stroke through the treatment of hypertension is well established and evidence from randomized controlled trials suggests the use of antihypertensive agents for the secondary prevention of vascular events in patients with previous stroke or transient ischaemic attack, the management of BP immediately after stroke has been an enigmatic controversy for more than two decades, exemplified by a debate published back in 1985 [31], and still remains uncertain. In experimental studies on rats, candesartan has been shown to be neuroprotective with both reduction of neurovascular damage, demonstrated by decreased infarct size, hemoglobin content and oedema in the ischaemic brain hemisphere, and improvement of neurological outcome.…”

Manejo da hipertensão arterial na isquemia cerebral aguda

“…Assim, não havia indicação formal para redução imediata da TA à luz dos conhecimentos atuais 7,8,9,18,20,23 .…”

Community of protein complexes impacts disease association

“…The observed associations between diseases may help us to identify new comorbidity patterns along their potential genetic origin. After examining the entire set of 1953 disease pairs that are genetically linked in our results, we found some disease pairs whose comorbidity patterns are already well known to the medical community, for example, hypertension and ischemic stroke 26,27 or diabetes mellitus and chronic anemia. 28 These examples demonstrate that the capacity of the protein complex-based approach in identifying potentially interesting disease pairs is worth of further research.…”

Elevated Blood Pressure in the Acute Phase of Stroke and the Role of Angiotensin Receptor Blockers

“…While the primary prevention of stroke through the treatment of hypertension is well established and evidence from randomized controlled trials suggests the use of antihypertensive agents for the secondary prevention of vascular events in patients with previous stroke or transient ischaemic attack, the management of BP immediately after stroke has been an enigmatic controversy for more than two decades, exemplified by a debate published back in 1985 [31], and still remains uncertain. In experimental studies on rats, candesartan has been shown to be neuroprotective with both reduction of neurovascular damage, demonstrated by decreased infarct size, hemoglobin content and oedema in the ischaemic brain hemisphere, and improvement of neurological outcome.…”

Manejo da hipertensão arterial na isquemia cerebral aguda

“…Assim, não havia indicação formal para redução imediata da TA à luz dos conhecimentos atuais 7,8,9,18,20,23 .…”