Hyperprolactinemia and Impotence

El-beheiry, A. H.; Souka, A R; El-Kamshoushi, A.; Hussein, Shatha Sami; El-sabah, K.

doi:10.3109/01485018808986743

Cited by 21 publications

(2 citation statements)

References 7 publications

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“…Although the penile blood vessels lie outside the radiation field, erectile dysfunction may be related to radiation damage to the small blood vessels and nerves that regulate the penile blood supply 43‐45. Polychemotherapy (PCT) may decrease testosterone levels through Leydig cell damage within the remaining testicle,43 or by hyperprolactinemia 46. However, Leydig cell dysfunction probably is temporary 47.…”

Section: Treatment‐related Biologic‐organic Influences On Sexual Funcmentioning

confidence: 99%

Sexual functioning after treatment for testicular cancer

Jonker-Pool¹,

Basten²,

Hoekstra³

et al. 1997

Cancer

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Medical information was obtained from the patient records. been treated with polychemotherapy (PCT) with or without resection of residual retroperitoneal tumor mass (RRRTM) (PCT { RRRTM) reported a significantly 3 Department of Urology, University Hospital Groningen, Groningen, The Netherlands. RESULTS.sharper decrease in sexual functioning than patients who had been followed with a wait-and-see policy (W & S) (Stage I nonseminoma patients). It was noteworthy 4 Department of Medical Oncology, University that patients treated by PCT alone reported more sharply decreased sexual funcHospital Groningen, Groningen, The Netherlands. ing, it appears that psychologic factors arising from the confrontation with testicular cancer play a strongly mediating (if not determining) role.

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Section: Treatment‐related Biologic‐organic Influences On Sexual Funcmentioning

confidence: 99%

Sexual functioning after treatment for testicular cancer

Jonker-Pool¹,

Basten²,

Hoekstra³

et al. 1997

Cancer

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“…Irradiation may cause small vessels disease and peripheral neuropathy resulting in erectile dysfunction (Fossa et al, 1980;von Eschenbach, 1980;Tomic et al, 1983;Goldstein et al, 1984;Fossa et al, 1986). The possible organic-biologic effects of chemotherapy itself are also complex, including temporary reduction of testosterone levels, hyperprolactinaemia, induction of vascular damage and peripheral neuropathy (El-Beheiry et al, 1988;Aass et al, 1991;van Basten et al, 1997a). Retroperitoneal lymph node dissection (RPLND) may cause permanent dry ejaculation due to the surgical interruption of retroperitoneal sympathetic nerves (Drasga et al, 1983).…”

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confidence: 99%

Long-term effects on sexual function and fertility after treatment of testicular cancer

et al. 1999

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Summary This retrospective study evaluates the types and incidences of sexual disturbances and fertility distress in patients cured from testicular cancer and examines whether there is an effect resulting from different treatment modalities. A self-reported questionnaire was sent to 124 randomly selected patients who were treated at Hanover University Medical School between 1970 and 1993. Ninety-eight patients were included in the study, representing a response rate of 78%. All patients had been in complete remission (CR) for at least 24 months. The median age at diagnosis was 28 years (range 17-44). The median follow-up at the time of study was 12.0 years (range 2.8-25.6). Twenty patients (20%) had been treated for seminomatous and 78 patients (80%) for non-seminomatous germ cell tumours. Treatment included surveillance (7%), primary retroperitoneal lymph node dissection (RPLND) (13%), chemotherapy (CT) (33%), CT + secondary resection of residual retroperitoneal tumour mass (SRRTM) (43%) and infradiaphragmatic radiotherapy (4%). Patients receiving two treatment modalities (CT+SRRTM) reported more frequent an unfulfilled wish for children. Inability of ejaculation was clearly associated with RPLND and SRRTM. Subjective aspects of sexuality, like loss of sexual drive and reduced erectile potential, occurred only in a minority of patients after treatment. No abnormalities were observed concerning the course of pregnancies of partners. In conclusion, sexual dysfunction and infertility are common long-lasting sequelae in testicular cancer survivors affecting approximately 20% of patients. The relative risk for infertility appeared to be elevated for patients treated with the combination of CT+SRRTM. Twenty-one of 40 patients were able to fulfil their wish for children, and no congenital abnormalities were observed in these children.

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Gynecomastia Associated With Calcium Channel Blocker Therapy

Tanner

Bosco²

1988

Arch Intern Med

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Hyperprolactinemia and Impotence

Cited by 21 publications

References 7 publications

Sexual functioning after treatment for testicular cancer

Sexual functioning after treatment for testicular cancer

Long-term effects on sexual function and fertility after treatment of testicular cancer

Gynecomastia Associated With Calcium Channel Blocker Therapy

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