Hyperkeratosis of nipple and areola

Schwartz, R. A.

doi:10.1001/archderm.114.12.1844

Cited by 11 publications

(2 citation statements)

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“…Hyperkeratosis of the nipple area has been reported in association with a range of diseases including benign and malignant forms of AN, atopic dermatitis, Darier disease, ichthyosis, hormonal disorders (diabetes mellitus, insulin resistance and thyroid disease), but also after pregnancy or in the context of nevoid hyperkeratosis of the nipple and areola or epidermal nevus [1,3,4,5]. …”

Section: Discussionmentioning

confidence: 99%

“Neglected nipples”: acanthosis nigricans-like plaques caused by avoidance of nipple cleansing

Kamińska‐Winciorek

Wydmański

Scope

et al. 2014

Dermatol Pract Concept

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Background:Acanthosis nigricans (AN) develops sporadically or in association with obesity, insulin-resistance and dark pigmentary phenotype. Unusual clinical presentations of AN may be diagnostically vexing.Objectives:The aim of the report is to present unusual clinical and dermoscopic pictures of hyper-keratotic, brownish lesions of the nipples resembling acanthosis nigricans. Patients/Methods: Data including clinical and dermoscopic features of two patients with the “neglected nipples”: acanthosis nigricans-like (AN-like) hyperpigmented plaques caused by avoidance of nipple cleansing.Results:Beside the anamnestic clue, presentation of AN-like plaques in the “neglected nipples” is limited to the breasts, in the absence of involvement of other flexural sites classically affected by AN. Dermoscopy aids the exclusion of a tumor, as it reveals exclusively structureless, brown-gray-black hyperkeratosis in the absence of criteria associated with melanocytic or non-melanocytic skin neoplasms of the nipple. The “neglected breasts” are easily treated by keratolytic creams and hygiene.Conclusions:The “neglected nipples” condition, presenting as bilateral AN-like papules and plaques of the nipples, is due to avoidance of cleansing of the nipple area, resulting in accumulation of keratotic cellular debris.

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Section: Discussionmentioning

confidence: 99%

“Neglected nipples”: acanthosis nigricans-like plaques caused by avoidance of nipple cleansing

Kamińska‐Winciorek

Wydmański

Scope

et al. 2014

Dermatol Pract Concept

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“…This form is rare in men, with only 6 cases reported to date. In 1978 Schwartz [2]and in 1980 Mold and Jegasothy [3]reported each the case of a man with prostatic adenocarcinoma treated with diethylstilbestrol who developed bilateral hyperkeratosis of their nipples and areolae. A possible endocrinopathy or a history of estrogen therapy was postulated as the cause of their hyperkeratosis.…”

Section: Introductionmentioning

confidence: 99%