Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B(-1)2, and vitamin B-6 status

Cravo, Marília; Glória, L; Selhub, Jacob; Nadeau, Marie; Camilo, M.; Resende, Ana; Cardoso, José; Leitão, C. Nobre; Mira, F. Costa

doi:10.1093/ajcn/63.2.220

Cited by 278 publications

(144 citation statements)

References 30 publications

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“…A large epidemiological study (the Caerphilly cohort) has suggested a link between beer consumption and lower tHcy concentration in men aged 50 ± 64 y (Ubbink et al, 1998). In another smaller study beer drinkers were found to have signi®cantly lower blood tHcy concentration than wine and spirit consumers (Cravo et al, 1996). Our study is consistent with these ®ndings because we only studied the alcohol intake from beer.…”

Section: Discussionsupporting

confidence: 88%

A population study of the influence of beer consumption on folate and homocysteine concentrations

2001

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Objective: Mild hyperhomocysteinemia is a signi®cant and independent risk factor for vascular diseases. Blood total homocysteine concentration (tHcy) is considered to be the product of an interaction between genetic and nutritional factors notably intake of folate, vitamin B 12 and pyridoxine. The aim of the study was to determine whether regular intake of beer containing large amount of folate and other vitamins in¯uences the tHcy blood concentrations. Design: Cross-sectional population-based survey. Setting: Adult population, residents of Pilsen (Czech Republic) and vicinity. Subjects: Population series included 292 males and 251 females aged 35 ± 65 y, mean age 53.4 y. All subjects were examined by a standard protocol for clinical, anthropometrical and laboratory estimations. Main outcome measures: tHcy was measured by high-pressure liquid chromatography with¯uorescent detection, blood folate and B 12 levels immunochemically using commercial kits. Results: Beer intake was associated with blood folate and vitamin B 12 concentrations positively and with tHcy concentration negatively. By categories of beer intake, subjects with intake of 1 l daily or more had signi®cantly lower tHcy and higher folate concentrations than those reporting lower daily beer intake. Conclusion: Moderate beer consumption may help to maintain the tHcy levels in the normal range due to high folate content. Folate from beer may thus contribute to the protective effect of alcohol consumption on cardiovascular disease in population with generally low folate intake from other nutrients.

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Section: Discussionsupporting

confidence: 88%

A population study of the influence of beer consumption on folate and homocysteine concentrations

2001

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“…Red wine and lower homocysteine concentration JB Dixon et al Cravo et al, 1996). Hyperhomocysteinemia has been found in rats after ethanol feeding (Stickel et al, 2000).…”

Section: Discussionmentioning

confidence: 98%

“…In addition, it has been shown that long-term ingestion of large quantities of ethanol causes inhibition of methionine synthase activity due to its breakdown product acetaldehyde (Kenyon et al, 1998) and it has been proposed that elevated blood levels of ethanol, rather than nutritional factors are responsible for changes in homocysteine metabolism (Bleich et al, 2000c). With high alcohol intake beer, rich in folate and vitamin B 6 , may reduce the risks of raised homocysteine concentrations (Cravo et al, 1996;van der Gaag et al, 2000). Elevated homocysteine concentrations in chronic alcoholics predict the risk of fitting with alcohol withdrawal (Bleich et al, 2000a) and may be an important factor related to the increased risk of direct neuronal damage (Bleich et al, 2000b) or stroke (Hultberg et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status

Dixon

O'Brien

2002

Eur J Clin Nutr

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Background: Moderate alcohol consumption is associated with improved vascular risk profile and decreased mortality in the middle aged. An elevated homocysteine concentration is an independent risk factor for cardiovascular disease. Objective: To examine the relationship between alcohol consumption and homocysteine concentrations in severely obese patients (body mass index (BMI) > 35). Design: A careful alcohol history was obtained from 350 (male : female 1 : 5) consecutive patients as part of preoperative assessment for surgical treatment of obesity. Data were obtained concerning amount, frequency, timing and type of alcohol consumption. Fasting homocysteine, serum folate and vitamin B 12 concentrations were measured. Differences between groups were assessed using Student t-test, and ANOVA. Linear regression was used to assess factors influencing homocysteine concentration.Results: There is a U-shaped relationship between alcohol consumption and homocysteine concentrations, with light to moderate consumption being associated with lower concentrations. Those consuming < 100 g=week (n ¼ 165) of alcohol had geometric mean (95% CI of mean) serum homocysteine concentrations of 8.5 (8.2 -8.9) mmol=l compared with 9.5 (9.1 -9.9) mmol=l for non or rare consumers (n ¼ 153; P ¼ 0.001). The lower concentrations of homocysteine in regular consumers were associated with higher folate concentrations of 9.4 (8.6 -10.2) ng=ml when compared with non-consumers 7.5 (7.1 -7.8) ng=ml (P ¼ 0.001). Red wine consumers (n ¼ 42) had lower fasting concentrations of homocysteine 7.8 (7.5 -8.1) mmol=l compared with 153 non-consumers 9.4 (9.0 -9.8) mmol=l (P < 0.001), 82 beer and spirit consumers 9.0 (8.4 -9.7) mmol=l (P ¼ 0.005) and 73 white wine consumers 8.8 (8.2 -9.4) mmol=l (P ¼ 0.013). Red wine consumption was an independent predictor for lower homocysteine concentrations. Conclusion: Mild to moderate alcohol consumption, especially red wine consumption, in obese subjects is associated with lower fasting homocysteine concentrations. This may reduce cardiovascular risk and help explain the 'French paradox'.

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“…Consumers of large quantities of alcohol have raised tHcy that are due to ethanol-induced B-vitamin depletion (Cravo et al, 1996;Koehler et al, 2001). The high concentrations of B-vitamins present …”

Section: Discussionmentioning

confidence: 99%

Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7)

et al. 2004

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Objective: To examine the associations between various lifestyle factors-smoking habits, physical activity, dietary habits, coffee, tea, and alcohol consumption-and homocysteine (tHcy) in relation to MTHFR(C677T) genotype. Design: Cross-sectional population-based study. Setting: Residents of Copenhagen County, Denmark. Subjects: A random sample of 6457 men and women aged 30-60 years drawn from the Civil Registration System and invited to a health examination in 1999-2001. A total of 2788 participants were included in the statistical analysis. Main outcome measures: tHcy was measured using a Fluorescent Polarization Immuno Assay. MTHFR-genotype was determined by PCR and RFLP analysis. Information about lifestyle factors was obtained from a self-administered questionnaire. Results: Daily smoking, less healthy dietary habits, and coffee drinking were associated with elevated tHcy concentrations independent of other determinants. Wine consumption was related to tHcy in a J-shaped manner, whereas beer consumption was negatively associated with tHcy after multiple adjustments. Interaction was observed between smoking status and MTHFRgenotype, smoking status and sex, and beer consumption and age. The effect of smoking was more pronounced in persons with the TT genotype and in women. The effect of beer consumption was more pronounced at younger than at older ages. Conclusions: Smoking status, dietary habits, coffee intake, wine, and beer consumption were major lifestyle determinants of tHcy. Changes in these lifestyle factors may reduce tHcy concentrations, thereby lowering cardiovascular risk in the general population.

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Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B(-1)2, and vitamin B-6 status

Cited by 278 publications

References 30 publications

A population study of the influence of beer consumption on folate and homocysteine concentrations

A population study of the influence of beer consumption on folate and homocysteine concentrations

Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status

Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7)

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