Hyperhidrosis: A Review of a Medical Condition

Mahendiran, Shavitri; Burkhart, Craig N.; Burkhart, Craig G.

doi:10.2174/1874372200903010195

Cited by 7 publications

(10 citation statements)

References 10 publications

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“…Hyperhidrosis is excessive sweating usually due to overactivity of cholinergic innervations of the sweat glands. It can be primary (idiopathic) or secondary to some other conditions such as diabetes mellitus, thyrotoxicosis, anxiety, menopause, peripheral neuropathies, Parkinsonism, and drugs such as selective serotonin reuptake inhibitors (SSRI), opioids, and tricyclic antidepressants (17). In this study, 13 patients in family group had hyperhidrosis, eight of them were receiving SSRI (three fluvoxamine, two escitalopram, two mirtazapine, and one fluoxetine), one was suffering from Parkinsonism, one hyperthyroidism, one diabetes mellitus, one associated with pitted keratolysis of soles, and in the other the cause was not known.…”

Section: Discussionmentioning

confidence: 99%

Pattern of dermatoses in two groups of admitted psychiatric patients: a cross-sectional study from a tertiary care hospital in Kashmir

Arif

Hassan

Margoob

et al. 2017

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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This study was carried out by Department of Dermatology and Department of Psychiatry at Government Medical College Srinagar, a tertiary care hospital of Kashmir valley of India. It was a cross-sectional study that involved only admitted patients with a primary psychiatric disorder at this hospital over the period of 1 year, from October 2012 to September 2013. The patients for the study were categorized into two groups as follows: Family ward: The first group comprised 100 psychiatric patients that were admitted to family wards with accompanying family members. These patients usually stay for a short duration of a few days or weeks (less than 1 month), usually admitted for exacerbation of their primary psychiatric disorder, and are well taken care of by their accompanying family members or relatives during their hospital stay. Once their symptoms improve, they are soon discharged. Inclusion criteria: 1) Diagnosis of psychiatric illness, 2) Admission to the hospital for less than 1 month, 3) Patient accompanied by one or more caretakers, 4) Residing in open wards with accompanying caretaker(s) free to move out. Closed Ward: The second group comprised 100 patients mostly suffering from longstanding schizophrenia that have been in the hospital for many months to years, mostly neglected by their families. They were kept in closed wards (custodial care) under security because many of them have lost any perspective on their disease. This group of patients was at some disadvantages such as lack of personal care, self-inflicted injuries, negligence by their families, and lack of interest from healthcare staff because some of them have become so aggressive as to pose a threat to other people; the long duration of disease was reflected in their skin manifestations. Inclusion criteria: 1) Diagnosis of psychiatric illness, 2) Admission to the hospital for more than 1 month (usually months to years), 3) Patients not accompanied by caretakers, 4) Residing under custodial settings (under security arrangements). Exclusion criteria (common for both groups): 1) Age less than 12 years, 2) Pregnancy or history of pregnancy in the last 6 months, 3) Patients whose dermatological condition was diagnosed before the onset of primary psychiatric illness.

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Section: Discussionmentioning

confidence: 99%

Pattern of dermatoses in two groups of admitted psychiatric patients: a cross-sectional study from a tertiary care hospital in Kashmir

Arif

Hassan

Margoob

et al. 2017

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…24 Finally, locally applied neostigmine suppressed inflammation in an inflamed mouse knee model, and topical AChEIs have shown promise in the treatment of hyperhidrosis. 25–27 Clearly, inhibition of AChE is a promising approach to treating inflammatory disorders. Furthermore, considering the well-documented role of both inflammation 6,7 and cholinergic dysfunction 16–18 in AD, anti-inflammatory AChEIs such as those presented herein represent a promising class of dual-action AD therapeutics.…”

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confidence: 99%

Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents

Saxena

Meloni

Huang

et al. 2015

Bioorganic & Medicinal Chemistry Letters

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Novel ethynylphenyl carbonates and carbamates containing carbon- and silicon-based choline mimics were synthesized from their respective phenol and aniline precursors and screened for anticholinesterase and anti-inflammatory activities. All molecules were micromolar inhibitors of acetylcholinesterase (AChE), with IC50s of 28–86 μM; the carbamates were two-fold more potent than the carbonates. Two of the most potent AChE inhibitors suppressed 12-O tetradecanoylphorbol-13-acetate (TPA)-induced inflammation by 40 %. Furthermore, these molecules have physicochemical properties in the range of other CNS drugs. These molecules have the potential to treat inflammation; they could also dually target Alzheimer’s disease through restoration of cholinergic balance and inflammation suppression.

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“…Focal hyperhidrosis is usually idiopathic, and affects mainly the palms, soles and axillae in an otherwise healthy person. It can have a marked negative effect on patients' quality of life …”

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confidence: 99%

“…Botulinum toxin type A injections and systemic anticholinergic treatment are available treatment options in secondary care. Surgical options such as axillary clearance and endoscopic thoracosympathectomy are reserved for those patients who have not responded to conservative measures …”

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confidence: 99%

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Tap water iontophoresis may be ineffective for axillary hyperhidrosis

2014

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with paraneoplastic SCLE was a supraglottic laryngeal SCC, reported by Chaudhry et al. in 2005. 4 Other cutaneous paraneoplastic syndromes that have been associated with head and neck malignancies include acrokeratosis paraneoplastica, dermatomyositis and eruptive seborrhoeic keratoses. 5 Regression of skin eruptions usually occurs after treatment of the primary malignancy.In our case, the patient underwent palliative radiotherapy for a locally advanced SCC that was not amenable tor surgery. His rash improved with topical betamethasone valerate 0.1% ointment and photoprotection. He did not require any systemic treatment, and was still in remission at follow-up 3 months later.

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Hyperhidrosis: A Review of a Medical Condition

Cited by 7 publications

References 10 publications

Pattern of dermatoses in two groups of admitted psychiatric patients: a cross-sectional study from a tertiary care hospital in Kashmir

Pattern of dermatoses in two groups of admitted psychiatric patients: a cross-sectional study from a tertiary care hospital in Kashmir

Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents

Tap water iontophoresis may be ineffective for axillary hyperhidrosis

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