Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type I diabetes mellitus

Jebbink, R. J. A.; Samsom, Melvin; Bruijs, P. P. M.; Bravenboer, Bert; Akkermans, L.M.A.; vanBerge-Henegouwen, Gerard P.; Smout, AndréJ.P.M.

doi:10.1016/0016-5085(94)90541-x

Cited by 136 publications

(114 citation statements)

References 33 publications

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“…Results of studies of GMA in persons with type 2 diabetes (Gad-el-Hak & Baker, 2001;Mathur, et al, 2001;Qi, Luo, & Wang, 2002) provided additional insight and knowledge into the complexity of GMA, GI symptoms, and metabolic control in this group of patients. Other studies (El-Salhy & Sitohy, 2001;Jebbink et al, 1994;Pfaffenbach et al, 1995) were unable to distinguish significant differences in gastric rhythm, symptoms, and blood glucose measures between persons with type 1 or type 2 diabetes and healthy controls. Methods used to study gastric dysrhythmias and their relationship to gastric symptoms and metabolic control in patients with diabetes have not been performed consistently.…”

Section: Overviewmentioning

confidence: 93%

“…Up to 76% of patients with diabetes in some reports, complain of these upper GI symptoms (Enck & Frieling, 1997;Horowitz & Fraser, 1995;Horowitz, Wishart, Jones, & Hebbard, 1996;Kong, Macdonald, & Tattersall, 1996), which appear to be associated with acute changes in blood glucose levels (hypo-and hyperglycemia), and altered patterns of GMA (Enck & Frieling, 1997;Kong, Macdonald, & Tattersall, 1996;Rothstein, 1999). Studies report that subjects with acute hyperglycemia experience more tachygastria, while subjects with chronically elevated blood glucose levels were more likely to be bradygastric (Mathur, et al, 2001;Jebbink, et al, 1994). Subjects with abnormal EGGs experienced greater GI signs and symptoms in some studies, but other studies report no relationship between GMA and GI signs and symptoms (Soykan, Lin, Sarosiek, & McCallum, 1999;Pfaffenbach, et al, 1995).…”

Section: Conceptual Frameworkmentioning

confidence: 99%

“…Information about immediate changes occurring in blood glucose levels relative to intake can be measured with this method (LifeScan, 2002). While acute changes in blood glucose levels may not affect the index for metabolic control (because of averaging of lows and highs over a 2-3 month period), these changes do affect GMA and the perception of symptoms during the episode (Barnett & Owyana, 1988;Jebbink et al, 1994). Recommended glycemic goals are 80-120 mg/dl preprandially and average bedtime glucose of 100-140 mg/dl (ADA, 2003).…”

Section: Bloatingmentioning

confidence: 99%

“…Alterations in blood glucose levels affect the nervous system resulting in changes in the digestive system (Fischer, Heidemann, Hengst, Domschke, & Konturek, 1998). Changes in the digestive system contribute to problems with maintaining metabolic control, creating a cyclic pattern that contributes to further complications (ElSalhy & Sitohy, 2001;Enck & Frieling, 1997;Jebbink et al, 1994).…”

Section: Gastric Complications In Patients With Diabetesmentioning

confidence: 99%

“…This study concluded that EGG was not a reliable tool for assessing gastric motility. Jebbink, et al (1994) examined the prevalence of gastric myoelectrical abnormalities and their relationship to upper GI symptoms in patients with type 1 diabetes. The study was performed in 30 patients (19 male, 11 female, mean age 45.5 ± 2.5 years) and 12 healthy sex, age, and weight matched controls (7 male, 5 female, mean age 46.3 ± 3.7 years).…”

Section: Gastric Myoelectrical Activity and Electrogastrographymentioning

confidence: 99%

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Gastric Myoelectrical Activity in Patients with Diabetes

Holmes¹

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This descriptive, correlational study investigated the associations among gastric myoelectrical activity (GMA), upper gastrointestinal (GI) symptoms, and glucose control.The study also attempted to determine whether any relationship existed between upper GI symptoms, glucose control, age, or length of diagnosis and pattern of GMA identified using electrogastrography (EGG).A total of 25 persons participated in the study. The sample was comprised of 7 healthy controls, 5 patients diagnosed with type 1 diabetes, and 13 patients diagnosed with type 2 diabetes. Demographic data, a health history, blood sampling, and assessment of historical and current upper GI symptoms were obtained. Electrogastrography was performed for 30 minutes in the fasting state and continued at 30-minute intervals for a total of 1-1/2 hours post-prandially. Data from the fasting, 30-minute post-prandial period, and 120-minute post-prandial periods were analyzed for the study.For research question one, non-significant p values were confirmed during fasting (p = .14) and 120-minutes post-prandial (p = .11). A significant p value was noted at 30-minutes post-prandial (p = .04). This suggests that no difference exist between patterns of GMA in healthy subjects and patients with diabetes except during the period immediately after eating. No significant differences in the pattern of GMA were identified in type 1 versus type 2 diabetic patients during any sampling period (p = .81, .49, and .88, respectively).Research question 2 looked at GMA during 3 periods. At the end of the fasting period (period 1), there were 7 patients with normogastria, 10 with bradygastria, and 1 vi with tachygastria. The bradygastric group reported greater mean scores for symptom presence and severity historically and during the fasting period on all upper GI signs and symptoms. During period 1, mean scores for satiety on the TSS scale were the only variable yielding any significant result (p = .04). For this sample, no relationship was found between the three patterns of GMA and acute blood glucose, metabolic control, age, or length of diagnosis in patients with diabetes who were fasting. During the first post-prandial period (30 minutes post meal; period 2), 4 subjects were normogastric, 7were bradygastric, and 7 were tachygastric. There were no significant differences found between the distributions of scores for the variables under study and patterns of GMA.During the 120-minute post prandial period (period 5), 6 subjects were normogastric, 7were bradygastric, and 5 were tachygastric. There were no significant differences found between the distributions of mean scores for the variables under study and patterns of GMA.In conclusion, findings of this study support the potential use of EGG as a screening tool in the detection of patterns of GMA in healthy and diabetic individuals.Using EGG, gastric myoelectrical activity can be identified in both healthy controls and patients diagnosed with diabetes. Further studies are needed to generate data that can be used to ...

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Section: Overviewmentioning

confidence: 93%

Section: Conceptual Frameworkmentioning

confidence: 99%

Section: Bloatingmentioning

confidence: 99%

Section: Gastric Complications In Patients With Diabetesmentioning

confidence: 99%

Section: Gastric Myoelectrical Activity and Electrogastrographymentioning

confidence: 99%

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Gastric Myoelectrical Activity in Patients with Diabetes

Holmes¹

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Electrogastrography (EGG)

Lin

Chen

2006

Wiley Encyclopedia of Biomedical Engineering

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Electrogastrography (EGG) is a noninvasive technique for the cutaneous recording of gastric myoelectrical activity. Since the first measurement of the electrogastrogram (EGG), a great deal of research has investigated its validation, interpretation, and application. Recently, EGG has received more and more attention. EGG has become an attractive tool to study the electrophysiology of the stomach and pathophysiology of gastric motility disorders. It is currently used in both research settings and clinical settings. The following areas are discussed: the refined methods of EGG, the advanced techniques for processing and analyzing the EGG, and the physiological and clinical applications of EGG.

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Gastrointentinal Manifestations of Systemic Diseases

Israeli

Bernstein

2015

Yamada' S Textbook of Gastroenterology

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Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type I diabetes mellitus

Cited by 136 publications

References 33 publications

Gastric Myoelectrical Activity in Patients with Diabetes

Gastric Myoelectrical Activity in Patients with Diabetes

Electrogastrography (EGG)

Gastrointentinal Manifestations of Systemic Diseases

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