Hypergammaglobulinemia is a marker of extraintestinal manifestations in pediatric inflammatory bowel disease

Matar, Michael A.; Rinawi, Firas; Shamir, Raanan; Assa, Amit

doi:10.5152/tjg.2017.16562

Cited by 5 publications

(6 citation statements)

References 8 publications

(8 reference statements)

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“…Although serum immunoglobulins levels in the background population could not be provided, the results of this study were compared with those of other studies and few differences were observed. Elevated serum IgG was identified in 24.5% of participants in the present cohort, which was comparable with a study that found 23% of pediatric CD patients had elevated serum IgG levels (16). Furthermore, 8.2% of patients in the present study had increased serum IgG4 levels, which was higher than the 6.34% reported in four kinds of autoimmune diseases, including primary Sjogren syndrome, systemic sclerosis, SLE, and primary biliary cirrhosis (9) and lower than the 9.9% reported in IBD patients in Sichuan, China (17).…”

Section: Discussionsupporting

confidence: 91%

“…In addition, a possible relationship between low serum IgG or IgG1 levels and the need for small bowel resection in patients with IBD has been reported ( 15 ). Furthermore, hypergammaglobulinemia defined as elevated IgG levels contributes to distinguishing arthritis from arthralgia in pediatric IBD ( 16 ). Patients with IBD having high levels of mucosal and serum IgG4 tend to have severe and extensive lesions ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

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Association of Serum Immunoglobulins Levels With Specific Disease Phenotypes of Crohn's Disease: A Multicenter Analysis in China

et al. 2021

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Background and Aim: Serum immunoglobulins were reported to be associated with clinical characteristics of inflammatory bowel disease. However, whether a difference exists in the serum immunoglobulins levels in patients with Crohn's disease (CD) with different disease location and behavior phenotypes remains unclear. Therefore, this study aimed to explore the associations of serum immunoglobulins levels with specific CD phenotypes.Methods: Patients with CD having recorded serum immunoglobulins levels were recruited through multicenter collaborative efforts. The associations between serum immunoglobulins levels and distinct phenotypes of CD were evaluated using multiple logistic regression models.Results: A total of 608 patients with CD were included in the study. Elevated (above the upper limit of normal) serum immunoglobulin G (IgG), IgA, IgM, and IgG4 were identified in 24.5, 17.4, 2.1, and 8.2% of patients, respectively. Elevated serum IgG4 levels negatively correlated with complicated disease behavior [odds ratio (OR) 0.49, 95% confidence interval (CI) 0.26–0.92]. Elevated serum IgG was linked to isolated ileal disease with an OR of 0.37 (95% CI 0.23–0.61). The ORs of isolated ileal disease progressively reduced across increasing quartiles of IgG (P for trend < 0.001). The adjusted ORs of isolated ileal disease for increasing quartiles of IgM were 1.82 (1.07–3.1), 1.92 (1.14–3.24), 1.17 (0.69–1.98), and 1 (P for trend = 0.008). Besides, serum IgA and IgG levels significantly correlated with several disease activity indices.Conclusions: These results suggested that certain serum immunoglobulins were associated with specific disease phenotypes of CD. Further investigations to account for the associations are warranted.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Association of Serum Immunoglobulins Levels With Specific Disease Phenotypes of Crohn's Disease: A Multicenter Analysis in China

et al. 2021

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“…Included studies were primarily observational single‐center studies ( 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ) (Table 1 ). These were most commonly retrospective cohort studies with limited prospective follow‐up.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of Musculoskeletal Manifestations in Pediatric Inflammatory Bowel Disease: A Systematic Review

Ali

Schmidt

Piskin

et al. 2022

ACR Open Rheumatology

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Objective Pediatric inflammatory bowel disease (p‐IBD) is a chronic relapsing gastrointestinal disorder of childhood with long‐term morbidity. Several extraintestinal manifestations are described, the most common being joint pain and/or inflammation. However, patient and disease characteristics, treatments, and outcomes of p‐IBD‐associated musculoskeletal disease are not well established. Our study aims to summarize the recent literature on the epidemiology of musculoskeletal manifestations in p‐IBD in the era of biologics. Methods A systematic search of PubMed, Embase, Cochrane Library, Web of Science Core Collection, and Cumulative Index to Nursing and Allied Health Literature databases was performed with relevant keywords. Studies in English published from January 1, 2000, to December 21, 2020, were included. In total, 3893 articles were identified and screened. Study and population characteristics and outcomes of interest were recorded. Risk of bias assessment was performed using the Joanna Briggs Institute Critical Appraisal Tools. Results Thirteen studies were included for full review, which were primarily single‐center observational studies with retrospective or cross‐sectional designs. The diagnostic criteria and definitions used for musculoskeletal manifestations varied. Musculoskeletal manifestation prevalence ranged from 2% to 35%. Only one study assessed the response of musculoskeletal manifestations to biologics. Risk of bias demonstrated heterogeneity in study quality. Conclusion This is the first systematic review of musculoskeletal manifestations in p‐IBD. Analysis was limited because of variability in study design and data‐reporting methods. Definitions varied among included studies, with a clear lack in standardization. Our study demonstrates the need for standardized assessment of musculoskeletal manifestations of p‐IBD and further research to explore optimal management to advance care for this group of children.

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“…In humans, SPE has been underused, but is promising in patients with intestinal bowel disease (IBD) and chronic liver diseases [13]. In addition, hypergammaglobulinemia in human IBD patients has been recently identified as a marker of extraintestinal manifestations [14,15] which often includes hepatic and pancreatic disease [16]. Concurrent pancreatic and/or hepatic diseases in cats with CE have often been found [17], which may contribute to TP and protein fraction alterations [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy

Pierini

Gori

Tulone

et al. 2022

Veterinary Sciences

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Few studies have investigated total protein (TP) and serum protein electrophoresis (SPE) in cats with chronic enteropathy (CE). Cats diagnosed with CE were evaluated to investigate the relationships between TP, SPE and endoscopy, histopathology, and extraintestinal involvement. Medical records were searched for cats with a history of chronic gastrointestinal signs and a final diagnosis of CE. Information on signalment, TP, SPE, endoscopic score, histopathological diagnosis and score, and concurrent hepatic or pancreatic ultrasonographic alterations was collected. Relationships between protein profiles and other variables were investigated. Ninety-nine cats were included in the study, 63 diagnosed with various degrees of bowel inflammation and 36 with small-cell alimentary lymphoma. The most common TP alteration was hypoproteinemia (24%). No significant differences were observed between protein profiles and endoscopic and histopathological severity scores. Forty-five cats showing concurrent pancreatic and/or hepatic ultrasonographic alterations, had significantly lower albumin, lower α-globulin, and higher γ-globulin levels than cats not showing concurrent alterations. Disease severity scores did not seem to influence the protein profile in cats with CE. Extraintestinal involvement may be suspected in cats with lower albumin and α-globulins and higher γ-globulins.

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Hypergammaglobulinemia is a marker of extraintestinal manifestations in pediatric inflammatory bowel disease

Cited by 5 publications

References 8 publications

Association of Serum Immunoglobulins Levels With Specific Disease Phenotypes of Crohn's Disease: A Multicenter Analysis in China

Association of Serum Immunoglobulins Levels With Specific Disease Phenotypes of Crohn's Disease: A Multicenter Analysis in China

Epidemiology of Musculoskeletal Manifestations in Pediatric Inflammatory Bowel Disease: A Systematic Review

Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy

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