Hyperfractionated or accelerated radiotherapy for head and neck cancer

First Description of Alpha/Beta Values in Pediatric Medulloblastoma: Implications for Tailored Approaches in Radiation Oncology

“…Our preclinical data provide evidence that medulloblastomas in children exhibit high alpha-beta values, indicating reduced sensitivity to fraction size. This is an observation that had been welldocumented in adult head and neck malignancies, where administering radiotherapy in smaller fractions is known to protect late-responding normal tissues in comparison to the tumor [15]. In the context of medulloblastoma, analogous clinical observations have substantiated our ndings.…”

First Description of Alpha/Beta Values in Pediatric Medulloblastoma: Implications for Tailored Approaches in Radiation Oncology

“…Our preclinical data provide evidence that medulloblastomas in children exhibit high alpha-beta values, indicating reduced sensitivity to fraction size. This is an observation that had been welldocumented in adult head and neck malignancies, where administering radiotherapy in smaller fractions is known to protect late-responding normal tissues in comparison to the tumor [15]. In the context of medulloblastoma, analogous clinical observations have substantiated our ndings.…”

Prospective Study to Compare Efficacy of Conventional Chemoradiotherapy with Hypofractionated Chemoradiotherapy in Locally Advanced Carcinoma of Oropharynx

“…This implies that patients with a large nodal burden are probably less likely to be benefited by hypofractionation. This finding is well-corroborated with MARCH collaborative group meta-analysis, which has shown that the effect of altered fractionation was significantly more pronounced on the primary tumor than on the nodal disease (Baujat et al, 2010). Another factor working in tumor control is tumor hypoxia.…”

Evaluation of purely accelerated six fractions per week radiotherapy in postoperative oral cavity squamous cell carcinoma

“…There was a stark difference in LRC rates of those patients who were started on RT < 11 weeks as compared to those beyond 13 weeks (76% vs 38%, P = .002). This study and several other studies and reviews mention the overall surgery‐RT completion time as a “treatment package time” and that it should be completed in a duration of ≤ 100 days. Altered fractionation RT using pure acceleration with same total dose and fractionation is one way to reduce the radiation OTT and, hence, improve outcomes .…”

First Description of Alpha/Beta Values in Pediatric Medulloblastoma: Implications for Tailored Approaches in Radiation Oncology

“…Our preclinical data provide evidence that medulloblastomas in children exhibit high alpha-beta values, indicating reduced sensitivity to fraction size. This is an observation that had been welldocumented in adult head and neck malignancies, where administering radiotherapy in smaller fractions is known to protect late-responding normal tissues in comparison to the tumor [15]. In the context of medulloblastoma, analogous clinical observations have substantiated our ndings.…”

Prospective Study to Compare Efficacy of Conventional Chemoradiotherapy with Hypofractionated Chemoradiotherapy in Locally Advanced Carcinoma of Oropharynx

“…This implies that patients with a large nodal burden are probably less likely to be benefited by hypofractionation. This finding is well-corroborated with MARCH collaborative group meta-analysis, which has shown that the effect of altered fractionation was significantly more pronounced on the primary tumor than on the nodal disease (Baujat et al, 2010). Another factor working in tumor control is tumor hypoxia.…”

Evaluation of purely accelerated six fractions per week radiotherapy in postoperative oral cavity squamous cell carcinoma

“…There was a stark difference in LRC rates of those patients who were started on RT < 11 weeks as compared to those beyond 13 weeks (76% vs 38%, P = .002). This study and several other studies and reviews mention the overall surgery‐RT completion time as a “treatment package time” and that it should be completed in a duration of ≤ 100 days. Altered fractionation RT using pure acceleration with same total dose and fractionation is one way to reduce the radiation OTT and, hence, improve outcomes .…”

First Description of Alpha/Beta Values in Pediatric Medulloblastoma: Implications for Tailored Approaches in Radiation Oncology

“…Our preclinical data provide evidence that medulloblastomas in children exhibit high alpha-beta values, indicating reduced sensitivity to fraction size. This is an observation that had been welldocumented in adult head and neck malignancies, where administering radiotherapy in smaller fractions is known to protect late-responding normal tissues in comparison to the tumor [15]. In the context of medulloblastoma, analogous clinical observations have substantiated our ndings.…”

Prospective Study to Compare Efficacy of Conventional Chemoradiotherapy with Hypofractionated Chemoradiotherapy in Locally Advanced Carcinoma of Oropharynx

“…This implies that patients with a large nodal burden are probably less likely to be benefited by hypofractionation. This finding is well-corroborated with MARCH collaborative group meta-analysis, which has shown that the effect of altered fractionation was significantly more pronounced on the primary tumor than on the nodal disease (Baujat et al, 2010). Another factor working in tumor control is tumor hypoxia.…”

Evaluation of purely accelerated six fractions per week radiotherapy in postoperative oral cavity squamous cell carcinoma

“…There was a stark difference in LRC rates of those patients who were started on RT < 11 weeks as compared to those beyond 13 weeks (76% vs 38%, P = .002). This study and several other studies and reviews mention the overall surgery‐RT completion time as a “treatment package time” and that it should be completed in a duration of ≤ 100 days. Altered fractionation RT using pure acceleration with same total dose and fractionation is one way to reduce the radiation OTT and, hence, improve outcomes .…”