Hypereosinophilic Syndrome With Peripheral Circulatory Insufficiency and Cutaneous Microthrombi

Hamada, Takahiro

doi:10.1001/archderm.143.6.812

Cited by 15 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Imaging studies were unremarkable for other underlying malignancy or evidence of embolism, and an extensive infectious disease workup and screen for connective tissue diseases were negative. The distribution of digital ischemia was clinically consistent with peripheral microthrombi rather than embolization . Following dexamethasone treatment to achieve a normal eosinophil count, the patient underwent bioprosthetic aortic valve replacement.…”

Section: Casementioning

confidence: 88%

See 1 more Smart Citation

Nonbacterial Thrombotic Endocarditis

Alaiti

Hoit

2015

Echocardiography

View full text Add to dashboard Cite

Mini‐Abstract A 61‐year‐old man with no medical history presented with necrosis of the fingers and toes in the setting of newly diagnosed multiple myeloma with profound eosinophilia. A crescendo–decrescendo murmur consistent with aortic stenosis was noted on exam. Transthoracic and transesophageal echocardiography revealed large mass on aortic valve resulting in severe stenosis. Imaging studies and extensive infectious workup were unremarkable for other underlying malignancy, evidence of embolism, infections, or connective tissue disease. Following dexamethasone treatment to achieve a normal eosinophil count, the patient underwent bioprosthetic aortic valve replacement. Pathologic examination was consistent with nonbacterial thrombotic endocarditis.

show abstract

Section: Casementioning

confidence: 88%

“…The distribution of digital ischemia was clinically consistent with peripheral microthrombi rather than embolization. 1 Following dexamethasone treatment to achieve a normal eosinophil count, the patient underwent bioprosthetic aortic valve replacement. Gross examination showed necrotic thrombi attached to aortic valve leaflets (Fig.…”

mentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis

Alaiti

Hoit

2015

Echocardiography

View full text Add to dashboard Cite

show abstract

“… 5 reported a 34‐year‐old patient with HES who presented with cutaneous necrotizing eosinophilic vasculitis and Raynaud’s phenomenon complicated by digital gangrene. There have been other published reports on HES accompanied by digital gangrene and Raynaud’s phenomenon in the English‐language literature 6,7 . Histopathological findings show necrotizing vasculitis of the small vessels with a prominent infiltrate of eosinophils 5 .…”

Section: Reportmentioning

confidence: 99%

“…Hamada et al. 6 reported a male patient with HES whose histopathological findings revealed prominent eosinophilic infiltration and multiple microthrombi in small blood vessels without vasculitis. Oppliger et al.…”

Section: Reportmentioning

confidence: 99%

Hypereosinophilic syndrome with various skin lesions and juvenile temporal arteritis

Ito

Hara

Okada

et al. 2009

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

Hypereosinophilic syndrome (HES) is a multisystem disease with a high mortality rate. It is characterized by peripheral blood eosinophilia and eosinophilic infiltration of the skin and many other organs. The commonest cutaneous features include erythematous pruritic maculopapules and nodules, angio-oedema or urticarial plaques. However, some case reports have indicated that eosinophilic cellulitis, cutaneous necrotizing eosinophilic vasculitis, Raynaud's phenomenon and digital gangrene may also occur as cutaneous features of HES. Juvenile temporal arteritis (JTA) of unknown cause is characterized by an asymptomatic nodule in the temporal artery area in young adults. Histologically, the lesion is characterized by a significant intimal thickening with moderate eosinophilic infiltrates, constriction or occlusion of the vascular lumen and absence of giant cells. We report a patient with HES presenting with eosinophilic cellulitis, Raynaud's phenomenon, digital gangrene and JTA. JTA may also be one of the features of HES.

show abstract

“…Für eine myeloproliferative oder eine T-Zell-assoziierte Form des HES ergaben sich keine Anhaltspunkte. Die stattgefundene Thrombose mit Lungenembolie passt zum HES, da eine Hypereosinophilie durch Modulation des MBP ("major basic protein") als prothrombotischer Faktor gilt [14]. Die schnelle Besserung nach Gabe von Glukokortikoiden und das fehlende Auftreten eines Rezidivs nach Absetzen der Prednisolontherapie sprechen ebenfalls für ein undefiniertes HES.…”

unclassified